Click here to switch to the map view.

The map label for this gene is holA [H]

Identifier: 161525899

GI number: 161525899

Start: 2981741

End: 2982835

Strand: Reverse

Name: holA [H]

Synonym: Bmul_2730

Alternate gene names: 161525899

Gene position: 2982835-2981741 (Counterclockwise)

Preceding gene: 161525900

Following gene: 161525898

Centisome position: 86.5

GC content: 71.05

Gene sequence:

>1095_bases
ATGCAATTGCGACTTGATGCACTGGAGCCGCACCTCGCGAAGGGGTTGGCCGGGCTCTACACCGTCTACGGCGACGAGCC
GCTGCTCGCGCAGGAGGCGTGCGACCGCATTCGCGCGGCCGCGCGCGCGGCCGGCTTCACCGAGCGTTCGGTGCATACGG
TCGAGCGCGGCTTCGACTGGAGCGTGCTGCTCGGCGCGACGCAGGCGATGTCGCTGTTCGGCGAGCGCCAGCTGATCGAG
CTGCGCATTCCGTCGGGCAAGCCGGGCAAGGAAGGGGCCGACGCGCTGAAGGCGCTGGCGGCCGCCGACAATCCCGATGC
GCTGATGCTCGTCACGCTGCCGCGTCTGGATGCGGCCACGCAGAAGTCCGCGTGGTTCACCGCGCTGCAGAACGGCGGCG
TCGCGCTGAAGATCGATCCGGTCGACCGCGCGCAGCTGCCGAACTGGATCGGCCAGCGGCTCGCGATGCAGGGGCAGCGC
GTCGCGCCCGGCGACGACGGCCGGCGCGCGCTGCAGTTCATCGCCGAGCGCGTCGAGGGCAATCTGCTCGCCGCGCATCA
GGAAATCCAGAAGCTCGGGCTGCTCTATCCGCAGGGCGTGCTGTCGTTCGAGCAGGTGCACGATGCCGTGCTGAACGTCG
CACGCTACGACGTGTTCAAGCTGAACGAAGCGATGCTTGCCGGCGACGCCGCGCGGCTCGCGCGGATGATCGACGGGCTC
AAGGGCGAGGGCGAGGCGATCGTGCTCGTGATGTGGGCCGTCGTCGAGGAGTTGCGCACGCTGCTGCGGATCAAGCGCGG
CACCGCGGCCGGCAAGCCGCTCGCGACGCTGCTGCGCGAGAACCGCGTATGGGGCCCGCGCGAGCGGCTGATCGGTCCGG
CGCTGAACCGCGTGTCCGAGGCCGTGCTCGAAAAGGCGCTCGCGTTTGCCGCGAAGCTCGACCGGCAAGTCAAGGGTCTC
GCCGCCGTGACGCCCGGCCGCCGCACGCACGACGATCCGCCGCCCGACCCGTGGGACGGGCTGTTTCAGCTCGCGATGAC
GGTCGCCGGGCCGCAGCACGAGCGACCGCCGACCGCGGGTCGCGTGCGGCGTTAG

Upstream 100 bases:

>100_bases
CGTGCATTCGCTGACGCCGCGTCCGGAAGACGTGGTGCCGGGCGTCGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTTT
GATTCGCGCCGCACGCACCG

Downstream 100 bases:

>100_bases
GTCCCGTTCCGGGCGTCAGCGTACGCATCGCAACCCGCTTACAATGCTCCGAAGCTGGCGCAGCCTGCCCGCCGCCGCAC
CGGGCGCCACGCCGCGCCAC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKALAAADNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLAMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTAAGKPLATLLRENRVWGPRERLIGPALNRVSEAVLEKALAFAAKLDRQVKGL
AAVTPGRRTHDDPPPDPWDGLFQLAMTVAGPQHERPPTAGRVRR

Sequences:

>Translated_364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKALAAADNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLAMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTAAGKPLATLLRENRVWGPRERLIGPALNRVSEAVLEKALAFAAKLDRQVKGL
AAVTPGRRTHDDPPPDPWDGLFQLAMTVAGPQHERPPTAGRVRR
>Mature_364_residues
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDWSVLLGATQAMSLFGERQLIE
LRIPSGKPGKEGADALKALAAADNPDALMLVTLPRLDAATQKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLAMQGQR
VAPGDDGRRALQFIAERVEGNLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
KGEGEAIVLVMWAVVEELRTLLRIKRGTAAGKPLATLLRENRVWGPRERLIGPALNRVSEAVLEKALAFAAKLDRQVKGL
AAVTPGRRTHDDPPPDPWDGLFQLAMTVAGPQHERPPTAGRVRR

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=313, Percent_Identity=33.5463258785943, Blast_Score=155, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39623; Mature: 39623

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKALAAADNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLAMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCCCHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTAAGKPLATLLRENRVWGPRERLIGPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLEKALAFAAKLDRQVKGLAAVTPGRRTHDDPPPDPWDGLFQLAMTVAGPQHERPPTAG
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RVRR
CCCC
>Mature Secondary Structure
MQLRLDALEPHLAKGLAGLYTVYGDEPLLAQEACDRIRAAARAAGFTERSVHTVERGFDW
CCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SVLLGATQAMSLFGERQLIELRIPSGKPGKEGADALKALAAADNPDALMLVTLPRLDAAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
QKSAWFTALQNGGVALKIDPVDRAQLPNWIGQRLAMQGQRVAPGDDGRRALQFIAERVEG
HHHHHHHHHCCCCEEEEECCCCHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPQGVLSFEQVHDAVLNVARYDVFKLNEAMLAGDAARLARMIDGL
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
KGEGEAIVLVMWAVVEELRTLLRIKRGTAAGKPLATLLRENRVWGPRERLIGPALNRVSE
CCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AVLEKALAFAAKLDRQVKGLAAVTPGRRTHDDPPPDPWDGLFQLAMTVAGPQHERPPTAG
HHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RVRR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]