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The map label for this gene is edd [H]

Identifier: 161525892

GI number: 161525892

Start: 2975384

End: 2977240

Strand: Reverse

Name: edd [H]

Synonym: Bmul_2723

Alternate gene names: 161525892

Gene position: 2977240-2975384 (Counterclockwise)

Preceding gene: 161525897

Following gene: 161525891

Centisome position: 86.34

GC content: 68.66

Gene sequence:

>1857_bases
ATGACGTCGCTGCATCCCACTCTGGCGAAAGTCACCGAACGCGTGATCGCCCGCAGCCAATCGACCCGTTCCGCCTATCT
GCAGCGCATCGACGGCGCGCAAGGCAAGTTCCCGGCGCGCGGCGCGCTGTCGTGCGCGAACCTCGCGCACGGTTTCGCGG
GCCTCGAGGGCAGCGACAAATTCGCGATCAAGGCGATTCGCGAGCCGAACATCGGCATCGTTTCGTCGTACAACGAGATG
CTGTCCGCGCATGCGCCGTACAAGAATTTCCCCGACATCATCAAGGCCGCCGCGCGCGAGAACGGCGGCGTCGCGCAGTT
CGCGGGCGGCGTGCCGGCGATGTGCGACGGCATCACGCAGGGCAATCCGGGGATGGAGCTGTCGCTGTTCTCGCGCGAGG
CCATCGCGATGGGCACGGCGATCGCGCTCACGCACAACATGTTCGACGCAGCGCTCTGCCTCGGCATCTGCGACAAGATC
GTGCCGGGCCTGCTGATCGGCGCGCTGCAGTTCGGCCACTTGCCGACGATCTTCGTGCCGGCCGGCCCGATGACGAGTGG
CCTGTCGAACGACGACAAGGCGAAGATCCGCCAGCAGTTCGCGACGGGCCAGGTCGGCCGCGACGCGCTGCTCGAAGCCG
AGTCGGCCGCCTATCACGGTCACGGCACCTGCACGTTCTACGGCACGGCGAACAGCAACCAGATGCTGATGGAGCTGATG
GGGCTGCATCTGCCGGGCGCCGCGTTCATCCATCCGCACACGCCGCTGCGCGACGCGCTGACGGCCGAAGCCGCGCGCCG
CGTGCTCGACCTGACCGTCGAGCGCGGCCAGTACACGCCGATCGGCCACGTGATCGACGAGAAGGCGATCGTCAACGGCA
TCGTCGCGCTGCTCGCGACCGGCGGCTCGACCAACCATACGCTGCACCTCGTCGCGATCGCGCGCGCGGCCGGCGTGCTG
ATCGACTGGAACGACTTCGACGAACTGTCGGCCGTCGTGCCGCTGCTCGCGAAGATCTACCCGAACGGCAAGGCCGACGT
GAACCATTTCCACGCGGCGGGCGGTGTCGCATTCCTCGTGCGCAACCTGCTCGAAGGCGGCCTGCTGCACGAAGACGTGA
CGACGGTCGCCGGCAAGGGGCTGTCGCACTACACGAAGGAGCCGAAGCTGATCGACGGCAAGCTGACGTGGGTCGACGGC
GCGGCCGAGAGTCACGACACGAAGGTGCTGCGCAGCATTCGCGATCCGTTCCAGCCGGACGGCGGCCTGCGTCTGATGCA
GGGCCGGCTCGGCCGCGGCGTGATCAAGATTTCGGCCGTCGCGCCCGAGCACCGCAAGGTGAAGGCGCCGGCGATCGTGT
TCGACTCGCAGGAAGCGGTGCAGGAAGCGTTCGATCGAGGCGAGCTGAAGCGCGATTTCGTCGCGGTCGTGCGGTTCCAG
GGCGCGCGTGCGAACGGCATGCCGGAGCTGCATCGTTTGACGCCGCTGCTCGGCGTGCTGCAGGATCAGGGCTTCCACGT
CGCGCTCGTCACCGACGGGCGCATGTCGGGCGCGTCGGGCAAGGTGCCGGCCGTGATCCATCTGTCGCCGGAAGCGCTGC
TCGGCGGCCCGATCGGCAAGGTGAAGACGGGCGACCTGCTCGTGATCGATGCGGAAGCCGGCGTGCTCGACATCGAGGTC
GACGCCGCCGAATGGGAGGCGCGCCCCGTCGCGCAGCCGCAGCATCAGGCCGACAACGAGGTCGGGTTCGGGCGCGAGCT
GTTCGGCGTGTTCCGCGCGGCGGCCGCGCCGGCCGAGCAGGGCGCATCGGTTTTCGGGACGCTGGTCGGCGAAACGGCCG
CCCGCGTTGCCGCGTGA

Upstream 100 bases:

>100_bases
CGCGTGTAGTTTTTCTACTAGACTGCGTTCGTTCGGTCGACGCATCGACCGTCCCCACGATTCCAACCGCCGGCGCGGCC
GGCATACAGGAGCGCCCAGC

Downstream 100 bases:

>100_bases
ATTTCCAGATCAAGGAGTGTTATCGATGAAGACGATTGCCGAAATCGTGAAGCTGGGCCCCGTCATTCCGGTGCTCGCGT
TCGACTCGGTCGAGCAGGGC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSSYNEM
LSAHAPYKNFPDIIKAAARENGGVAQFAGGVPAMCDGITQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGAAFIHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLSHYTKEPKLIDGKLTWVDG
AAESHDTKVLRSIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLGGPIGKVKTGDLLVIDAEAGVLDIEV
DAAEWEARPVAQPQHQADNEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAARVAA

Sequences:

>Translated_618_residues
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSSYNEM
LSAHAPYKNFPDIIKAAARENGGVAQFAGGVPAMCDGITQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKI
VPGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
GLHLPGAAFIHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVL
IDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLSHYTKEPKLIDGKLTWVDG
AAESHDTKVLRSIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLGGPIGKVKTGDLLVIDAEAGVLDIEV
DAAEWEARPVAQPQHQADNEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAARVAA
>Mature_617_residues
TSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDKFAIKAIREPNIGIVSSYNEML
SAHAPYKNFPDIIKAAARENGGVAQFAGGVPAMCDGITQGNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIV
PGLLIGALQFGHLPTIFVPAGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELMG
LHLPGAAFIHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLATGGSTNHTLHLVAIARAAGVLI
DWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLVRNLLEGGLLHEDVTTVAGKGLSHYTKEPKLIDGKLTWVDGA
AESHDTKVLRSIRDPFQPDGGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQG
ARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLGGPIGKVKTGDLLVIDAEAGVLDIEVD
AAEWEARPVAQPQHQADNEVGFGRELFGVFRAAAAPAEQGASVFGTLVGETAARVAA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=58.4717607973422, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=546, Percent_Identity=31.6849816849817, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI2367371, Length=529, Percent_Identity=30.4347826086957, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786464, Length=492, Percent_Identity=31.3008130081301, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=527, Percent_Identity=29.0322580645161, Blast_Score=188, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 65254; Mature: 65123

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDK
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FAIKAIREPNIGIVSSYNEMLSAHAPYKNFPDIIKAAARENGGVAQFAGGVPAMCDGITQ
EEEEEECCCCCCEEECHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
GLHLPGAAFIHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGVLIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGKGLSHYTKEPKLIDGKLTWVDGAAESHDTKVLRSIRDPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHHCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHCC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLGGPIGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VKTGDLLVIDAEAGVLDIEVDAAEWEARPVAQPQHQADNEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHC
GASVFGTLVGETAARVAA
CHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSLHPTLAKVTERVIARSQSTRSAYLQRIDGAQGKFPARGALSCANLAHGFAGLEGSDK
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
FAIKAIREPNIGIVSSYNEMLSAHAPYKNFPDIIKAAARENGGVAQFAGGVPAMCDGITQ
EEEEEECCCCCCEEECHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHCCCCC
GNPGMELSLFSREAIAMGTAIALTHNMFDAALCLGICDKIVPGLLIGALQFGHLPTIFVP
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AGPMTSGLSNDDKAKIRQQFATGQVGRDALLEAESAAYHGHGTCTFYGTANSNQMLMELM
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHH
GLHLPGAAFIHPHTPLRDALTAEAARRVLDLTVERGQYTPIGHVIDEKAIVNGIVALLAT
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GGSTNHTLHLVAIARAAGVLIDWNDFDELSAVVPLLAKIYPNGKADVNHFHAAGGVAFLV
CCCCCCEEEEEEEHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHH
RNLLEGGLLHEDVTTVAGKGLSHYTKEPKLIDGKLTWVDGAAESHDTKVLRSIRDPFQPD
HHHHCCCCCHHHHHHHHCCCHHHHCCCCCEECCEEEEECCCCCCHHHHHHHHHHCCCCCC
GGLRLMQGRLGRGVIKISAVAPEHRKVKAPAIVFDSQEAVQEAFDRGELKRDFVAVVRFQ
CCCEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHHCC
GARANGMPELHRLTPLLGVLQDQGFHVALVTDGRMSGASGKVPAVIHLSPEALLGGPIGK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCHHHHCCCCCC
VKTGDLLVIDAEAGVLDIEVDAAEWEARPVAQPQHQADNEVGFGRELFGVFRAAAAPAEQ
CCCCCEEEEECCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHC
GASVFGTLVGETAARVAA
CHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]