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The map label for this gene is pntAA [H]

Identifier: 161525853

GI number: 161525853

Start: 2930965

End: 2932104

Strand: Reverse

Name: pntAA [H]

Synonym: Bmul_2684

Alternate gene names: 161525853

Gene position: 2932104-2930965 (Counterclockwise)

Preceding gene: 161525857

Following gene: 161525852

Centisome position: 85.03

GC content: 70.09

Gene sequence:

>1140_bases
ATGCATATTGGAGTGCCTGCTGAGACGCGGGCCAACGAGGCGCGCGTCGCCGCGACGCCGGAGACCGTGAAGAAGTACGC
GGCCGCCGGCCACCGCGTCAGCGTCGCGAAGGGGGCCGGCACTGCGGCCAGCTATCCGGACGAAGCCTATGCGGCCGCCG
GCGCGGAATTGACCGACCAGTCGGCCGCTTTTGGCGCCGACATCGTGCTGAAGGTGCAGGCGCCGACCGATGCGGAACTG
CCGTCGCTGAAGCGCGGCGCGGTGCTGGTCGGAATGCTCGAGCCGTTCAATGCCGAGCAGGCGGCGAAGCTCGCGGCGAC
CGGCGTGACGGGCTTCGCGCTCGAAGCCGCGCCGCGCACGACGCGCGCGCAAAGTCTCGACGTGCTGTCGTCGCAGGCGA
ACATCGCCGGCTACAAGGCCGTGCTGGTCGCCGCGTCGCTCTATCCGCGCTTCCTGCCGATGCTGATGACGGCCGCGGGC
ACCGTGAAGGCCGCGCGCGTACTGGTGCTCGGCGCCGGCGTGGCCGGCCTGCAGGCGATCGCGACCGCGAAGCGGCTCGG
CGCCGTGATCGAGGCCTCCGACGTGCGGCCCGCCGTGAAGGAGCAGATCGAATCGCTCGGCGCGAAATTCCTCGACGTTC
CCTACGAAACCGACGAAGAGCGCGACGCCGCGCAGGGCGTCGGCGGCTATGCGCGGCCGATGCCGCCGTCGTGGCTCGCG
CGTCAGGCCGCGCTCGTGCACGAGCGCGCGAAGCAGGCCGACATCGTGATCACGACCGCGCTGATTCCGGGCCGCCCTGC
GCCGACCTTGATCTCGGCCGAGACCGTGCAGGCGATGAAGCCCGGCTCGGTGCTCGTCGATCTCGCGGCCGGCCGCGGGC
CGGAGGTCGACGGCCGCAAGGGCGGCAACTGCCCGCTGACGGTGGCCGACCAGGTGATCGTGCACAACGGCGTGACGATC
GCGGGCCATACGAATCTCGCCTCGATGGTCGCGTCGGATGCGTCCGCGCTCTACGCGCGCAACCTGCTCGATTTCATGAA
GCTGATCGTCACGAAGGAAGGTGTGCTGAACATCGACCTCGCCGACGACATCGTCGCGGCGACGCTGTTGTGCCGCGACG
GCGAAGTGACGCGCAAATAA

Upstream 100 bases:

>100_bases
GAACGCCGTTGCCCGTGAGCCGGTAGTCAGCCTGTCCGGCTCGTTGTTGCAGTCAGAATCGCAAGACTAGAAATATCAAC
GATGACTGGAGGAACTGACG

Downstream 100 bases:

>100_bases
CGGAGGAGACCATGGAAGTCATCAATCACACGGTGATCAACGTGATCATCTTCGTGCTGGCGGTGTACGTCGGCTACCAC
GTCGTCTGGAACGTCACGCC

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSVAKGAGTAASYPDEAYAAAGAELTDQSAAFGADIVLKVQAPTDAEL
PSLKRGAVLVGMLEPFNAEQAAKLAATGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLISAETVQAMKPGSVLVDLAAGRGPEVDGRKGGNCPLTVADQVIVHNGVTI
AGHTNLASMVASDASALYARNLLDFMKLIVTKEGVLNIDLADDIVAATLLCRDGEVTRK

Sequences:

>Translated_379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSVAKGAGTAASYPDEAYAAAGAELTDQSAAFGADIVLKVQAPTDAEL
PSLKRGAVLVGMLEPFNAEQAAKLAATGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLISAETVQAMKPGSVLVDLAAGRGPEVDGRKGGNCPLTVADQVIVHNGVTI
AGHTNLASMVASDASALYARNLLDFMKLIVTKEGVLNIDLADDIVAATLLCRDGEVTRK
>Mature_379_residues
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSVAKGAGTAASYPDEAYAAAGAELTDQSAAFGADIVLKVQAPTDAEL
PSLKRGAVLVGMLEPFNAEQAAKLAATGVTGFALEAAPRTTRAQSLDVLSSQANIAGYKAVLVAASLYPRFLPMLMTAAG
TVKAARVLVLGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMPPSWLA
RQAALVHERAKQADIVITTALIPGRPAPTLISAETVQAMKPGSVLVDLAAGRGPEVDGRKGGNCPLTVADQVIVHNGVTI
AGHTNLASMVASDASALYARNLLDFMKLIVTKEGVLNIDLADDIVAATLLCRDGEVTRK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=393, Percent_Identity=37.9134860050891, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI122939153, Length=393, Percent_Identity=37.9134860050891, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1787887, Length=380, Percent_Identity=44.7368421052632, Blast_Score=304, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI17550456, Length=377, Percent_Identity=41.1140583554377, Blast_Score=269, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39086; Mature: 39086

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSVAKGAGTAASYPDEAYAAAGAELTDQ
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCC
SAAFGADIVLKVQAPTDAELPSLKRGAVLVGMLEPFNAEQAAKLAATGVTGFALEAAPRT
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAASLYPRFLPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMPPSWLA
HHHHHHHHHHCCCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLISAETVQAMKPGSVLVDLAAGRGPEVDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEECCCCCCCCCCCC
GGNCPLTVADQVIVHNGVTIAGHTNLASMVASDASALYARNLLDFMKLIVTKEGVLNIDL
CCCCCEEECCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
ADDIVAATLLCRDGEVTRK
HHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHIGVPAETRANEARVAATPETVKKYAAAGHRVSVAKGAGTAASYPDEAYAAAGAELTDQ
CCCCCCCCCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCC
SAAFGADIVLKVQAPTDAELPSLKRGAVLVGMLEPFNAEQAAKLAATGVTGFALEAAPRT
CCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEECCCCC
TRAQSLDVLSSQANIAGYKAVLVAASLYPRFLPMLMTAAGTVKAARVLVLGAGVAGLQAI
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPYETDEERDAAQGVGGYARPMPPSWLA
HHHHHHHHHHCCCCCCHHHHHHHHHHCHHEECCCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAALVHERAKQADIVITTALIPGRPAPTLISAETVQAMKPGSVLVDLAAGRGPEVDGRK
HHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHHHHCCCCCEEEEECCCCCCCCCCCC
GGNCPLTVADQVIVHNGVTIAGHTNLASMVASDASALYARNLLDFMKLIVTKEGVLNIDL
CCCCCEEECCEEEEECCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEH
ADDIVAATLLCRDGEVTRK
HHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]