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The map label for this gene is glyA [H]

Identifier: 161525750

GI number: 161525750

Start: 2805187

End: 2806434

Strand: Reverse

Name: glyA [H]

Synonym: Bmul_2581

Alternate gene names: 161525750

Gene position: 2806434-2805187 (Counterclockwise)

Preceding gene: 161525759

Following gene: 161525749

Centisome position: 81.38

GC content: 65.14

Gene sequence:

>1248_bases
ATGTTTGACAGAGCCCAAAGCACCATCGCGAACGTCGATCCCGAAGTCTTTGCAGCGATCGAGCAGGAAAACCGTCGCCA
GGAAGAGCACATCGAGCTGATCGCGTCGGAAAACTACACGAGCCCGGCCGTGATGGCCGCGCAGGGCTCGCAGCTCACGA
ACAAGTACGCGGAAGGCTATCCGGGCAAGCGCTACTACGGCGGGTGCGAGTATGTCGACGTCGTCGAGCAGCTCGCGATC
GACCGCGTCAAGCAACTGTTCGGCGCCGAAGCGGCCAACGTGCAGCCGAACTCGGGCTCGCAGGCGAACCAGGGCGTGTT
CTTCGCGATGCTCAAGCCGGGCGACACGATCATGGGCATGAGCCTCGCGCACGGCGGCCACCTCACGCACGGCTCGCCGG
TCAACATGTCGGGCAAGTGGTTCAACGTGGTCAGCTACGGGCTGAACGAGAACGAAGACATCGACTACGAAGCGGCCGAG
AAGCTCGCGCAGGAACACAAGCCGAAGCTGATCGTCGCGGGCGCGTCGGCGTTCGCGCTGAAGATCGACTTCGAGCGTCT
GGCGAAGATCGCGAAGTCGGTCGGCGCATACCTGATGGTCGACATGGCGCACTACGCGGGGCTGATCGCCGCGGGCGTCT
ATCCGAACCCGGTGCCGCACGCCGACTTCGTCACGACGACCACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAGTACGAGAAGCAGATCAACTCGGCGATCTTCCCGGGCATCCAGGGCGGTCCGCTGATGCACGTGAT
CGCAGCGAAGGCCGTAGCGTTCAAGGAAGCGCTGTCGCCGGAGTTCAAGGCCTATCAGCAGAAGGTGGTCGAGAACGCCC
GTGTGCTGGCCGAGACGCTCGTCAAGCGCGGCCTGCGGATCGTGTCGGGCCGCACCGAAAGCCACGTGATGCTGGTCGAC
CTGCGTGCGAAGAACATCACCGGCAAGGCGGCGGAAGCCGCGCTGGGCGCCGCGCACATCACCGTGAACAAGAACGCGAT
TCCGAACGATCCGGAAAAGCCGTTCGTGACGAGCGGCATTCGTCTGGGCTCGCCGGCGATGACCACGCGCGGCTTCGGCC
CGGCCGAAGCGGAGCAGGTCGGCAACCTGATCGCCGACGTGCTCGAGAACCCGGAAGACGCAGCGACGATCGAGCGCGTG
CGCGCACAGGTCGCCGAGCTGACCAAGCGCTTCCCGGTCTACCGCTGA

Upstream 100 bases:

>100_bases
CTCGCGTCACTCGGATTCTTCCGCCACGTCGAGCTGGTCCTGCCAGCAGCGCAGTGTACTCGGCCACCCGGTCAACCTGT
ACACACTTAACGGAAACCGT

Downstream 100 bases:

>100_bases
TCGACGATGCGCTGCCCGTTCTGCCGGCACGAAGACACGCAAGTCGTTGACTCCCGCGTGTCCGAGGATGGCGCCGCGAT
TCGCCGGCGCCGTCGCTGCT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFDRAQSTIANVDPEVFAAIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR

Sequences:

>Translated_415_residues
MFDRAQSTIANVDPEVFAAIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR
>Mature_415_residues
MFDRAQSTIANVDPEVFAAIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGMSLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAE
KLAQEHKPKLIVAGASAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVD
LRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERV
RAQVAELTKRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=40.7488986784141, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=40.7488986784141, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=40.7488986784141, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=40.7488986784141, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=40.1766004415011, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=43.2242990654206, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI22547189, Length=413, Percent_Identity=41.6464891041162, Blast_Score=288, Evalue=9e-78,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=64.2512077294686, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25144732, Length=441, Percent_Identity=43.9909297052154, Blast_Score=352, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=441, Percent_Identity=43.9909297052154, Blast_Score=351, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=411, Percent_Identity=46.4720194647202, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=433, Percent_Identity=43.64896073903, Blast_Score=338, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24640005, Length=455, Percent_Identity=42.6373626373626, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221329721, Length=455, Percent_Identity=42.6373626373626, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44876; Mature: 44876

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDRAQSTIANVDPEVFAAIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEKLAQEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQQKVVENARVLAETL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDRAQSTIANVDPEVFAAIEQENRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAHGGHLTHGSPVNMSGKWFNVVSYGLNENEDIDYEAAEKLAQEHKPKLIVAGASAFAL
EECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEE
KIDFERLAKIAKSVGAYLMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEYEKQINSAIFPGIQGGPLMHVIAAKAVAFKEALSPEFKAYQQKVVENARVLAETL
EEECHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
VKRGLRIVSGRTESHVMLVDLRAKNITGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGI
HHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHCEEEEEECCCCCCCCCCCCCEECCE
RLGSPAMTTRGFGPAEAEQVGNLIADVLENPEDAATIERVRAQVAELTKRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA