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The map label for this gene is thiD [H]

Identifier: 161525696

GI number: 161525696

Start: 2745472

End: 2746443

Strand: Direct

Name: thiD [H]

Synonym: Bmul_2527

Alternate gene names: 161525696

Gene position: 2745472-2746443 (Clockwise)

Preceding gene: 161525687

Following gene: 161525708

Centisome position: 79.61

GC content: 68.83

Gene sequence:

>972_bases
ATGGGCGCACAGTGCGGCCTGCCGGGCAACACGGGGCCCGACGGCCCGTCGCCTGCTGCCGCCGCACCTCCGTCGCTTCC
CCGTATTTTTCTTGCCCTTTTTTCCATGTCCAGCAACGCCCCTCCGATCGTCCTCACCTTCGGCCTGTCCGATCCCACCG
GCGGCTCCGGCCTCCAAGCCGATCTGATGACCCTGGCGAGCATGGGCTGCCACGGCGTGTCCGTCCTTACCGGCTATACC
GTGCGCGACTCGGCTGCCTGCGATGAAGTGACCGGCCTCGATCCCGACATCGTCGCCGCGCAGGCGCGCATGCTGCTCGA
GGACATGCCGGTCGCCGCGTTCAAGATCGGCGCGGCGACGCGCGCGGAAGTCGTCAGCGCGATCGCCGAAGTGGTCGCCG
ACTACGACGGCGTACCGCTGGTGCTCGCGCCGGACTTCACGCTCGACGACGAGCACGTGCTCGCCGCCGACGATCTGCGC
GAGTCGATCGCCGATCTGCTCGCGCCGCAGACGACGCTGCTCGTCGCCGATCACGCGACGCTGATCGCGCTCGCGCAGCC
GGACGGCGATGCGGAAGCGCCGAATCTGGATGCGGCCGTGTCGCATCTGCTGTCGCAGGGCTGTGAATACATCCTGTCGT
CGGAAACGGGCTCGCACCGGCTCGTGAACACGCTGTACGGCGAAGAAGGCCAGCTGCGCGAAGACATGTGGGACCGCTCG
CCGCACCGGCTGATGGGCATCACCGATACGCTCGGCGCGGCAATTGCGGCGCTGCTCGCGAACGGCCAGGAACCGCCCGA
GGCCGTGCGCGAAGCGCAGGAATATCTGTATCAAGCGGTGCGCGACGCGTTCCGGCCCGGGATGGGTGCGTATCTGCCCG
ACCGCTTCTTCTGGGCCCGCAGCAACGAGGATGCCGATGCGCCGCCGGCCGCCGCGGTCGAGCCTCTGCCGCGGACGTCG
CATCGGCATTGA

Upstream 100 bases:

>100_bases
ACCGTGTCGGGGCCGGACTGCCTAGCAATCGCGCTGGAGTGCAGCGACTACGTTGTGCTGCGCTAAAAAATCCGTCGTAT
CGGCCGGATTCCGCCGCATA

Downstream 100 bases:

>100_bases
GTCGGCGCGCGGCCCTTCGCGGATCGCGCCGATTCGGCCGCCGCCGGCCCTCCCCTTCGCGCCGCGCGCAGATAAAAAAA
GACCCGCATCGCTGCGGGTC

Product: phosphomethylpyrimidine kinase type-1

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MGAQCGLPGNTGPDGPSPAAAAPPSLPRIFLALFSMSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYT
VRDSAACDEVTGLDPDIVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLR
ESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRS
PHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWARSNEDADAPPAAAVEPLPRTS
HRH

Sequences:

>Translated_323_residues
MGAQCGLPGNTGPDGPSPAAAAPPSLPRIFLALFSMSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYT
VRDSAACDEVTGLDPDIVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLR
ESIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRS
PHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWARSNEDADAPPAAAVEPLPRTS
HRH
>Mature_322_residues
GAQCGLPGNTGPDGPSPAAAAPPSLPRIFLALFSMSSNAPPIVLTFGLSDPTGGSGLQADLMTLASMGCHGVSVLTGYTV
RDSAACDEVTGLDPDIVAAQARMLLEDMPVAAFKIGAATRAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRE
SIADLLAPQTTLLVADHATLIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRSP
HRLMGITDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWARSNEDADAPPAAAVEPLPRTSH
RH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=244, Percent_Identity=29.0983606557377, Blast_Score=81, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 33876; Mature: 33745

Theoretical pI: Translated: 4.09; Mature: 4.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAQCGLPGNTGPDGPSPAAAAPPSLPRIFLALFSMSSNAPPIVLTFGLSDPTGGSGLQA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHH
DLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDIVAAQARMLLEDMPVAAFKIGAAT
HHHHHHHHCCCCCHHHCCCEECCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHH
RAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHAT
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCE
LIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRS
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHCCC
PHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWAR
CCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
SNEDADAPPAAAVEPLPRTSHRH
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GAQCGLPGNTGPDGPSPAAAAPPSLPRIFLALFSMSSNAPPIVLTFGLSDPTGGSGLQA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHH
DLMTLASMGCHGVSVLTGYTVRDSAACDEVTGLDPDIVAAQARMLLEDMPVAAFKIGAAT
HHHHHHHHCCCCCHHHCCCEECCCCCHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHH
RAEVVSAIAEVVADYDGVPLVLAPDFTLDDEHVLAADDLRESIADLLAPQTTLLVADHAT
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCE
LIALAQPDGDAEAPNLDAAVSHLLSQGCEYILSSETGSHRLVNTLYGEEGQLREDMWDRS
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHCCC
PHRLMGITDTLGAAIAALLANGQEPPEAVREAQEYLYQAVRDAFRPGMGAYLPDRFFWAR
CCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEC
SNEDADAPPAAAVEPLPRTSHRH
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]