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The map label for this gene is glk [H]

Identifier: 161525603

GI number: 161525603

Start: 2647497

End: 2649425

Strand: Direct

Name: glk [H]

Synonym: Bmul_2433

Alternate gene names: 161525603

Gene position: 2647497-2649425 (Clockwise)

Preceding gene: 161525602

Following gene: 161525605

Centisome position: 76.77

GC content: 67.96

Gene sequence:

>1929_bases
ATGTCTACTGGTGCGCAAAGTAAGGCCGTCGTCGCGGGCCAGCATGCCGACGGCCCGCGCCTGCTCGCGGACGTCGGCGG
CACCAACGCGCGCTTCGCGCTGGAGACCGGGCCGGGCGAGATCACGCAGATCCGCGTGTATCCCGGCGCCGATTACCCGA
CGCTCACCGATGCGATCCGCAAATACCTGAAGGACGTGAAGATCAGCCGCGTGAACCATGCGGCGATCGCGATCGCGAAT
CCGGTCGACGGCGATCAGGTGACGATGACGAACCACGACTGGAGCTTCTCGATCGAGGCGACGCGCCGCGCGCTCGGCTT
CGATACGCTGCTCGTCGTCAACGACTTCACGGCGCTCGCGATGGCGCTGCCGGGCCTGACCGACGCGCAGCGCGTGCAGA
TCGGCGGCGGCACGCGCCGCCAGAACAGCGTGATCGGGCTGCTCGGGCCCGGCACGGGGCTCGGCGTATCGGGCCTGATT
CCTGCCGACGATCGCTGGATCGCGCTCGGCAGCGAAGGCGGCCACGCATCGTTCGCCCCGCAGGACGAACGCGAGGATCT
CGTGCTGCAGTACGCGCGCAAGAAGTTTCCGCACGTGTCGTTCGAGCGCGTCTGCGCGGGGCCCGGCATCGAGATCATCT
ATCGCGCGCTCGCCGCGCGCGACAAGAAGCGCGTCGCCGCGAACGTCGATACCGCCGAAGTCGTCGAGCGCGCGCATGCG
GGCGATGCGCTCGCGCTCGAGACGGTCGAATGCTTCTGCGGCATCCTCGGCTCGTTCGCGGGCAGCGTCGCGCTGACGCT
CGGCGCGCTCGGCGGCGTCTATATCGGCGGCGGCGTCGCGCTGAAGCTCGGCGAACTGTTCACGCGCTCGTCGTTCCGCG
CGCGCTTCGAGGCGAAGGGCCGCTTCACGCACTATCTGCAGAACATCCCGACCTACCTGATCACCGCCGAATATCCGGCG
TTCCTCGGCGTGTCGGCGATTCTCGCGGAGCAGCTGTCGAACCGCTCGGGCGGCGCATCGTCGGCCGTGTTCGAGCGGAT
CCGCCAGATGCGCGACGCGCTGACGCCGGCCGAACGCCGCGTCGCCGATCTCGCGCTGAACCATCCGCGCTCGATCATCA
ACGATCCGATCGTCGACATCGCGCGCAAGGCCGACGTGAGCCAGCCGACCGTGATCCGCTTCTGCCGCTCGCTCGGCTGC
CAGGGGCTATCCGACTTCAAGCTGAAGCTCGCGACCGGGCTCACCGGCACGATTCCGATGAGCCACAGCCAGGTGCATCT
CGGCGACACGGCGACCGACTTCGGCGCGAAGGTGCTCGACAACACGGTGTCCGCGATCCTGCAGCTGCGCGAGCATCTGA
ATTTCGAGCATGTCGAGAACGCAATCGAGATCCTGAACGGCGCGCGCCGCATCGAGTTCTACGGGCTCGGCAACTCGAAC
ATCGTCGCGCAGGACGCGCATTACAAGTTCTTCCGCTTCGGCATTCCGACGATCGCGTACGGCGACCTGTACATGCAGGC
TGCCTCCGCGGCGCTGCTCGGCAAGGGCGACGTGATCGTCGCGGTATCGAAATCGGGACGCGCGCCCGAGCTGCTGCGCG
TGCTCGAGGTGGCGATGCAGGCGGGCGCGAAGGTGATCGCGATCACGTCGAGCAATACGCCGCTCGCGAAGCGCGCGACC
GTCGCGCTCGAGACCGATCACATCGAGATGCGCGAGTCGCAGCTGTCGATGATCTCGCGGATCCTGCATCTGCTGATGAT
CGACATCCTCGCGGTCGGCGTCGCGATCCGCCGCGCATCGCCGAACGACGCGCTACCCGAAGCGCTCGCGCAGGCGAAGG
CGCGCGCGAACGACGAGGAAACGGCCGACGTGCTCGACTGGCTCAGCCACGGCGCGTCGCCGGCCGCGAAGGACGTCGCG
CGCGACTGA

Upstream 100 bases:

>100_bases
ATCGCGGGCGACCGCAAGCGCGAAGTGCTCGACGCCGCGGCCGCGTCGCTGCAGAAGAACGCGATTTCCCAACTGGCCAA
CGACAAGGGGACCAAGCTCG

Downstream 100 bases:

>100_bases
CGCAGCGCGCTCGCGGGCACGCCTGCGCGTGCCCAAAGCAAAACGCCACCGGCGCAAGCGCGCGCGGTGGCGTTTTGCAT
GCGGCGACGCGCTCAGGCGG

Product: bifunctional glucokinase/RpiR family transcriptional regulator

Products: NA

Alternate protein names: Glucokinase; Glucose kinase; Putative HTH-type transcriptional regulator [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTLTDAIRKYLKDVKISRVNHAAIAIAN
PVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLLGPGTGLGVSGLI
PADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGIEIIYRALAARDKKRVAANVDTAEVVERAHA
GDALALETVECFCGILGSFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLQNIPTYLITAEYPA
FLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLEVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASPNDALPEALAQAKARANDEETADVLDWLSHGASPAAKDVA
RD

Sequences:

>Translated_642_residues
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTLTDAIRKYLKDVKISRVNHAAIAIAN
PVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLLGPGTGLGVSGLI
PADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGIEIIYRALAARDKKRVAANVDTAEVVERAHA
GDALALETVECFCGILGSFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLQNIPTYLITAEYPA
FLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGC
QGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLEVAMQAGAKVIAITSSNTPLAKRAT
VALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASPNDALPEALAQAKARANDEETADVLDWLSHGASPAAKDVA
RD
>Mature_641_residues
STGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTLTDAIRKYLKDVKISRVNHAAIAIANP
VDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALAMALPGLTDAQRVQIGGGTRRQNSVIGLLGPGTGLGVSGLIP
ADDRWIALGSEGGHASFAPQDEREDLVLQYARKKFPHVSFERVCAGPGIEIIYRALAARDKKRVAANVDTAEVVERAHAG
DALALETVECFCGILGSFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKGRFTHYLQNIPTYLITAEYPAF
LGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQ
GLSDFKLKLATGLTGTIPMSHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSNI
VAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLEVAMQAGAKVIAITSSNTPLAKRATV
ALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRASPNDALPEALAQAKARANDEETADVLDWLSHGASPAAKDVAR
D

Specific function: Not Highly Important In E.Coli As Glucose Is Transported Into The Cell By The Pts System Already As Glucose 6-Phosphate. [C]

COG id: COG0837

COG function: function code G; Glucokinase

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788732, Length=321, Percent_Identity=44.8598130841121, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788159, Length=256, Percent_Identity=36.71875, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI87082369, Length=288, Percent_Identity=27.7777777777778, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788767, Length=249, Percent_Identity=27.3092369477912, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082130, Length=226, Percent_Identity=28.3185840707965, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003836
- InterPro:   IPR000843
- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02685 Glucokinase; PF01418 HTH_6; PF01380 SIS [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 68599; Mature: 68468

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTLTDAIR
CCCCCCCCEEEECCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDVKISRVNHAAIAIANPVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGGGTRRQNSVIGLLGPGTGLGVSGLIPADDRWIALGSEGGHASFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
QDEREDLVLQYARKKFPHVSFERVCAGPGIEIIYRALAARDKKRVAANVDTAEVVERAHA
CCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHCC
GDALALETVECFCGILGSFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHCCC
RFTHYLQNIPTYLITAEYPAFLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERR
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLEVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNDALPEALAQAKARANDEETADVLDWLSHGASPAAKDVARD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure 
STGAQSKAVVAGQHADGPRLLADVGGTNARFALETGPGEITQIRVYPGADYPTLTDAIR
CCCCCCCEEEECCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHH
KYLKDVKISRVNHAAIAIANPVDGDQVTMTNHDWSFSIEATRRALGFDTLLVVNDFTALA
HHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHCCCEEEEHHHHHHHH
MALPGLTDAQRVQIGGGTRRQNSVIGLLGPGTGLGVSGLIPADDRWIALGSEGGHASFAP
HHCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
QDEREDLVLQYARKKFPHVSFERVCAGPGIEIIYRALAARDKKRVAANVDTAEVVERAHA
CCCHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHCC
GDALALETVECFCGILGSFAGSVALTLGALGGVYIGGGVALKLGELFTRSSFRARFEAKG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHCCC
RFTHYLQNIPTYLITAEYPAFLGVSAILAEQLSNRSGGASSAVFERIRQMRDALTPAERR
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHH
VADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPM
HHHHHHCCCHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
SHSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVENAIEILNGARRIEFYGLGNSN
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEEECCCCC
IVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLEVAMQ
EEEECCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLLMIDILAVGVAIRRAS
CCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PNDALPEALAQAKARANDEETADVLDWLSHGASPAAKDVARD
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA