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The map label for this gene is serS [H]

Identifier: 161525589

GI number: 161525589

Start: 2631148

End: 2632449

Strand: Reverse

Name: serS [H]

Synonym: Bmul_2419

Alternate gene names: 161525589

Gene position: 2632449-2631148 (Counterclockwise)

Preceding gene: 161525591

Following gene: 161525587

Centisome position: 76.34

GC content: 66.9

Gene sequence:

>1302_bases
ATGCTTGACATCCAGCTGCTGCGCAAAGACCTCGACGGCGTCGCGAAGCGCCTCGCCGATCGCGGCTACACCCTCGACGT
CGCCGCGTTCTCCGCGCTCGAAGCGGAACGCCGCGCGATCCAGACCCGCACCGAAGAGCTCCAGGCACGCCGCAACACGC
TGTCGAAGCAGATCGGCGCGATGAAGGCGAAGGGCGAGGACACGTCGGCCGTGATGGCCGAGGTCGGCGGGATCGGCGAC
GAGATGAAGGCATCGGCGGCGAAGCTCGACGAGATCCAGGCGCGCCTGTCGGAGCTGCTGCTGGGCATGCCGAACCTCGC
GCACGAAAGCGTGCCGGTCGGCAAGGACGAGGCCGACAACGTCGAGGTGCGCCGCTGGGGCACGCCGCGCCAGTTCGACT
TCGACGTGAAGGATCACGTCGACATCGGTACGCCGCTCGGCCTCGATTTCGAGACGGGCGCGAAGCTGGCCGGCGCGCGC
TTCACGATGCTGCGCGGCCCGATCGCGCGCCTGCATCGCGCGCTTGCGCAGTTCATGCTCGATACGCATACGCAGCAGCA
CGGCTACAGCGAGACGTACACGCCGTACATCGTGAATCCGGAGATCCTGTACGGCACGGGCCAGCTGCCGAAGTTCGCGG
ACGACATGTTCCGCGTCGAGAAGGGCGGTGCCGAGAACACGGTCACGCAATACCTGATCTCGACGTCCGAGATCTCGCTG
ACGAACACCGTGCGCGAGTCGATCGTCGAAGCGTCCGCGCTGCCGATCAAGCTCACGGCCCATTCGCCGTGCTTCCGTTC
GGAGGCCGGCTCGTACGGCCGCGACACGCGCGGGATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGATCG
TCGCGCCGGAGTCGTCGTATGCGGCGCTCGACGAAATGGTCGGCCACGCGGAAGCGATTCTGCAGAAGCTCGGCCTGCCG
TACCGCGTGGTCGCGCTCTGCACGGGCGACATGGGTTTCTCGGCCGCGAAGACGTTCGATCTCGAGGTGTGGCTGCCGGC
GCAGAACACGTATCGCGAGATCTCGAGCTGCTCGAACACCGAGGCGTTCCAGGCGCGCCGCATGCAGGCGCGCTTCCGCA
ACGCGCAGGGCAAGCCGGAGCTCGTGCATACGCTGAACGGTTCGGGGCTCGCGGTCGGCCGTACGCTCGTCGCGGTGCTC
GAGAACTACCAGAACGCGGACGGTTCGGTCACGGTGCCGGAAGTACTGCGTCCGTACATGGGCGGTCTGGAGCGAATCGA
CGCGCCGGCACAGGCGTCGTAA

Upstream 100 bases:

>100_bases
ACCGCCCGAGGTTTTCCGTCATCGTCCGCCCGGCCGATGCGTTGGCGGTGCCGCCGTGCGTTAGAATCCCCGTCTTACAC
AACGATTTTCCAGTCCTCCC

Downstream 100 bases:

>100_bases
CCGCGCGCGACGATGCGCATGCCACGCCCCGCAAAAAAATTCGCAAAAAGGGCTTGGAAGTTTCGCGGAGTTCGTTCTAT
AATCTTTGCTTTCCCGGAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGAMKAKGEDTSAVMAEVGGIGD
EMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADNVEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGLERIDAPAQAS

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGAMKAKGEDTSAVMAEVGGIGD
EMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADNVEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGLERIDAPAQAS
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGAMKAKGEDTSAVMAEVGGIGD
EMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADNVEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGAR
FTMLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
TNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSYAALDEMVGHAEAILQKLGLP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEVLRPYMGGLERIDAPAQAS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=34.5415778251599, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI8923421, Length=419, Percent_Identity=29.1169451073986, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI225579074, Length=348, Percent_Identity=31.3218390804598, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=63.8694638694639, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI17539260, Length=467, Percent_Identity=33.6188436830835, Blast_Score=234, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=30.5389221556886, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=33.9901477832512, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=384, Percent_Identity=30.9895833333333, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24581334, Length=470, Percent_Identity=32.9787234042553, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17737985, Length=344, Percent_Identity=31.6860465116279, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47539; Mature: 47539

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAKGEDTSAVMAEVGGIGDEMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADN
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHH
TNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSY
HHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
GGLERIDAPAQAS
CCHHHCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNTLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKAKGEDTSAVMAEVGGIGDEMKASAAKLDEIQARLSELLLGMPNLAHESVPVGKDEADN
HHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRQFDFDVKDHVDIGTPLGLDFETGAKLAGARFTMLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCHHHH
TNTVRESIVEASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPESSY
HHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQKLGLPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEVLRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
GGLERIDAPAQAS
CCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA