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The map label for this gene is gmk [H]

Identifier: 161525571

GI number: 161525571

Start: 2614992

End: 2615675

Strand: Reverse

Name: gmk [H]

Synonym: Bmul_2401

Alternate gene names: 161525571

Gene position: 2615675-2614992 (Counterclockwise)

Preceding gene: 161525572

Following gene: 161525570

Centisome position: 75.85

GC content: 64.91

Gene sequence:

>684_bases
ATGACCGAATCCACCCGCGACGGCCACGCGTCGCATTCACTGCACGGCGGCGTTTATCCCGGCAACCTGTTCATGGTCGT
CGCGCCGTCGGGCGCCGGCAAGTCGACGCTCGTGAATGCGCTGCTGTCGAAGGACAGCGACATCCGCCTGTCGATCTCGT
ACACGACGCGCAAGCCGCGTCCGGGCGAGCAGGACGGCCAGCACTATCATTTCACGACGGTCGAGGATTTCCGTGCGCGC
CACGCGGCGCACGAATTCCTCGAAAGCGCGGAAGTGCACGGCAACTACTACGGCACGTCGCGCGTCTGGATCGAAGAGCA
GATGAAGAGCGGCCACGACGTGCTGCTCGAGATCGACTGGCAGGGCGCGCAGCAGGTGAAGAAGCAGTTCCGCAACGCGG
TCGGCATCTTCATTCTGCCGCCGTCGCTCGACGCGCTCGAGGAGCGGCTGAAAAAGCGCGGCCAGGACGAGCCGAACGTG
ATCACGCGACGCCTGCTCGCGGCGGGCAGCGAGATGGCGCACGCGTCCGAAGCCGAGTACGTCGTGATCAACGAGAACTT
CGATCGTGCGCTCGCGGAGCTCGAATGCATCGTCGCGGCGACGCGTCTGCGCTTTGCGTCGCAGTACGCGCGGCACACGG
AGCTGTTCATCGAACTCGGTATCCATCTGCCCCACGCGGAATGA

Upstream 100 bases:

>100_bases
TCGAAGGCAGCGGCGAAGGAACTCGCCGACGCGTCGATGGCGCTGAAGCTGCTGATCGAGCAGATGCGCGAGCAAGTGCA
AAACCTGGAGTAAAAGCAAG

Downstream 100 bases:

>100_bases
CGCGGGGCATGAGGGACATAAGGTAGAATAAGGACTATATTCAGAAGGAATTACCAACATGGCTCGCATTACTGTCGAAG
ACTGCCTGAAGCAAATCCCG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTESTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE

Sequences:

>Translated_227_residues
MTESTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRAR
HAAHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNV
ITRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
>Mature_226_residues
TESTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDIRLSISYTTRKPRPGEQDGQHYHFTTVEDFRARH
AAHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDWQGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVI
TRRLLAAGSEMAHASEAEYVVINENFDRALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=40, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=40, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=40, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=28.735632183908, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI262118259, Length=173, Percent_Identity=28.9017341040462, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4505237, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118255, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21361598, Length=198, Percent_Identity=25.2525252525253, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118263, Length=173, Percent_Identity=28.9017341040462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI52630447, Length=198, Percent_Identity=24.7474747474747, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=49.2537313432836, Blast_Score=203, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=35.5555555555556, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=35.5555555555556, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=25.6830601092896, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=171, Percent_Identity=26.9005847953216, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=38.4615384615385, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356141, Length=182, Percent_Identity=37.9120879120879, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45554489, Length=177, Percent_Identity=25.9887005649718, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640542, Length=177, Percent_Identity=25.9887005649718, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI85724806, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554481, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161077626, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007136, Length=177, Percent_Identity=25.9887005649718, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 25446; Mature: 25315

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDIRLSISYTTRKPR
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDW
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEEEC
QGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEMAHASEAEY
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFDRALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
TESTRDGHASHSLHGGVYPGNLFMVVAPSGAGKSTLVNALLSKDSDIRLSISYTTRKPR
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
PGEQDGQHYHFTTVEDFRARHAAHEFLESAEVHGNYYGTSRVWIEEQMKSGHDVLLEIDW
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEECCEEEEHHHHHCCCCEEEEEEEC
QGAQQVKKQFRNAVGIFILPPSLDALEERLKKRGQDEPNVITRRLLAAGSEMAHASEAEY
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCE
VVINENFDRALAELECIVAATRLRFASQYARHTELFIELGIHLPHAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA