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The map label for this gene is pcoA [H]

Identifier: 161525508

GI number: 161525508

Start: 2547261

End: 2549141

Strand: Direct

Name: pcoA [H]

Synonym: Bmul_2338

Alternate gene names: 161525508

Gene position: 2547261-2549141 (Clockwise)

Preceding gene: 161525505

Following gene: 161525509

Centisome position: 73.87

GC content: 67.62

Gene sequence:

>1881_bases
ATGACGCGCTATCCCCCCCATGCTCCACGGCCCCTGATCCTGTCACGGCGGCGATTCGTGCAGGGATTGGCGGCGGGCGG
CGTCCTGCTCGGCTTGTCCACGCCCGCCTTGAAGGCCGCGGCCCAGCAGGCGCGGGCCGCCAGCGGCACCGCTCCGGTGC
TGCGCGGCACGGAGTTCGACCTGGTGATCGCCGAGTCCCCCGTGAACTTCACCGGCCAGCCGGGCATGGCTACCACGATC
AACGGCTCGCTGCCCGCGCCCACGCTGCGCTGGCGCGAAGGGGACACGGTCACAATCCGCGTCACCAACCGGCTGCGCGA
GTCCACCTCCATCCATTGGCACGGCATCATCCTGCCCTACCAGATGGACGGCGTGCCGGGCATCAGCTTCGGCGGTATCG
CGCCGGGGGAAACCTTCACCTACCGCTTCAAGGTCAGCCAGAGCGGCACCTACTGGTACCACTCGCATTCCGGCTTCCAG
GAACAAACGGGCATGTACGGGGCGATCATCATCGACCCCGCCGGCCCTGAAACCATCCGCGCCGAGCGCGACCACGTCGT
GCTTCTGACGGACTGGACCGATGAAGACCCCATGCGTGTCTTCATGAAGCTCAAGACCCAGGGCGACTACTACAACTACC
ACCAGCCGACGGCGGTGGACTTCTTCCGCGATGCCTCACGCGAGGGCGTCTCGGTCGCGCTGGACAAGCGCAAGATGTGG
AACCAGATGCGCATGAGCCCGACGGACCTCTCGGATCTCTCGGCGCAGACCTTGACCTATCTGGCCAACGGCACCACGCC
CGCCGGCAACTGGACCGGCCTGTTCCGTCCCGGCGAGCGCGTGCGCCTGCGCTTCATCAACGGGGCCGGCAACACCTTCT
ACGACGTGCGCATTCCGGGCCTGAAACTGAAGGTCGTGCATGTCGATGGCGTGGACGTCGAGCCGGTCACGGTGGACGAG
TTCCGCTTCGGTCCGGGCGAGACCTGCGACGTGCTGGTCGAGCCACACGACGACGCTTACACGATCTTCGCGCAATCCAT
GGATCGCACGGGCTATGCCCGAGGCACGCTGGCGGTACGCGCCGGGCTTAGCGCGCCCGTGCCGCCGATGGACGCGGCCC
CGTGGCTGTCGATGGCGGACATGATGGGCGCGATGGACCATGGCGACATGGCAGGCATGGCGGGTATGTCCGGCATGGCC
GGGATGGACCACGGCTCCATGGCCGGGATGGATCACGGCGCCATGGCCGGCATGGATCACGGTTCCATGCAGGGAATGAC
GGGGATGAGCGGCATGACCGGCATGGATTCCGGCCAGATGCAGGGCATGGACAGCACCAATCCTCTGGCCGTGCCCAGCA
CCACCGTGCGGCACGCCCGAACGGAGTACGGGCCAGGGACGGACATGCGCGTGGACATGCCGCGCACCGCGCTGGACGAC
CCGGGCATCGGATTGCGCAACAACGGCCGGCGCGTGCTGACCCTGGCCGACCTGCACACGCCCGGCGGCCCCATGGACCC
GCGCGGCCCCGGCCGCGAGGTCGAGCTGCACCTCACCGGCAACATGGAGCGCTACACCTGGTCCATCGACGGGCTCGAAT
TCAGCAAGTCCAAGCCGGTGCATTTCCGCCACGGCGAGCGGCTGCGCGTCATCTTGCACAACGACACGATGATGACGCAC
CCGATGCACCTGCACGGGATGTGGAGCGAACTGGAGAGCCCCGACGGGCGCTTCCTGGCACGGCGCCACACCTTGCCCGT
GCAGCCGGCGCAGCGCCTGAGCTTCCTGGTCACCGCCGATGCGCTGGGACGCTGGGCCTGGCACTGCCACCTGATGCTTC
ACATGGATGCGGGCATGTTCCGCGAGGTCGTGGTGTCTTGA

Upstream 100 bases:

>100_bases
TGGCGCCTCTCTAGCATGGTCATCAACGGCGTAAAAGCGCGCTCCCATTCAAGGACCTCGCGCGTGCCCTTCGATGTCTG
TTTATGGAGAGTTTTTCGTC

Downstream 100 bases:

>100_bases
GCGCCGCTTGAAGAGAGTGCACGAACAATGAAAACAACACACCTCCACGCATTGACCCTGGCACTGGTTGCCACGATCGC
GAACCCCGTGCTGGCCCAGT

Product: CopA family copper resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTRYPPHAPRPLILSRRRFVQGLAAGGVLLGLSTPALKAAAQQARAASGTAPVLRGTEFDLVIAESPVNFTGQPGMATTI
NGSLPAPTLRWREGDTVTIRVTNRLRESTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVSQSGTYWYHSHSGFQ
EQTGMYGAIIIDPAGPETIRAERDHVVLLTDWTDEDPMRVFMKLKTQGDYYNYHQPTAVDFFRDASREGVSVALDKRKMW
NQMRMSPTDLSDLSAQTLTYLANGTTPAGNWTGLFRPGERVRLRFINGAGNTFYDVRIPGLKLKVVHVDGVDVEPVTVDE
FRFGPGETCDVLVEPHDDAYTIFAQSMDRTGYARGTLAVRAGLSAPVPPMDAAPWLSMADMMGAMDHGDMAGMAGMSGMA
GMDHGSMAGMDHGAMAGMDHGSMQGMTGMSGMTGMDSGQMQGMDSTNPLAVPSTTVRHARTEYGPGTDMRVDMPRTALDD
PGIGLRNNGRRVLTLADLHTPGGPMDPRGPGREVELHLTGNMERYTWSIDGLEFSKSKPVHFRHGERLRVILHNDTMMTH
PMHLHGMWSELESPDGRFLARRHTLPVQPAQRLSFLVTADALGRWAWHCHLMLHMDAGMFREVVVS

Sequences:

>Translated_626_residues
MTRYPPHAPRPLILSRRRFVQGLAAGGVLLGLSTPALKAAAQQARAASGTAPVLRGTEFDLVIAESPVNFTGQPGMATTI
NGSLPAPTLRWREGDTVTIRVTNRLRESTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVSQSGTYWYHSHSGFQ
EQTGMYGAIIIDPAGPETIRAERDHVVLLTDWTDEDPMRVFMKLKTQGDYYNYHQPTAVDFFRDASREGVSVALDKRKMW
NQMRMSPTDLSDLSAQTLTYLANGTTPAGNWTGLFRPGERVRLRFINGAGNTFYDVRIPGLKLKVVHVDGVDVEPVTVDE
FRFGPGETCDVLVEPHDDAYTIFAQSMDRTGYARGTLAVRAGLSAPVPPMDAAPWLSMADMMGAMDHGDMAGMAGMSGMA
GMDHGSMAGMDHGAMAGMDHGSMQGMTGMSGMTGMDSGQMQGMDSTNPLAVPSTTVRHARTEYGPGTDMRVDMPRTALDD
PGIGLRNNGRRVLTLADLHTPGGPMDPRGPGREVELHLTGNMERYTWSIDGLEFSKSKPVHFRHGERLRVILHNDTMMTH
PMHLHGMWSELESPDGRFLARRHTLPVQPAQRLSFLVTADALGRWAWHCHLMLHMDAGMFREVVVS
>Mature_625_residues
TRYPPHAPRPLILSRRRFVQGLAAGGVLLGLSTPALKAAAQQARAASGTAPVLRGTEFDLVIAESPVNFTGQPGMATTIN
GSLPAPTLRWREGDTVTIRVTNRLRESTSIHWHGIILPYQMDGVPGISFGGIAPGETFTYRFKVSQSGTYWYHSHSGFQE
QTGMYGAIIIDPAGPETIRAERDHVVLLTDWTDEDPMRVFMKLKTQGDYYNYHQPTAVDFFRDASREGVSVALDKRKMWN
QMRMSPTDLSDLSAQTLTYLANGTTPAGNWTGLFRPGERVRLRFINGAGNTFYDVRIPGLKLKVVHVDGVDVEPVTVDEF
RFGPGETCDVLVEPHDDAYTIFAQSMDRTGYARGTLAVRAGLSAPVPPMDAAPWLSMADMMGAMDHGDMAGMAGMSGMAG
MDHGSMAGMDHGAMAGMDHGSMQGMTGMSGMTGMDSGQMQGMDSTNPLAVPSTTVRHARTEYGPGTDMRVDMPRTALDDP
GIGLRNNGRRVLTLADLHTPGGPMDPRGPGREVELHLTGNMERYTWSIDGLEFSKSKPVHFRHGERLRVILHNDTMMTHP
MHLHGMWSELESPDGRFLARRHTLPVQPAQRLSFLVTADALGRWAWHCHLMLHMDAGMFREVVVS

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=445, Percent_Identity=26.0674157303371, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=284, Percent_Identity=29.5774647887324, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320714, Length=292, Percent_Identity=26.3698630136986, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=279, Percent_Identity=29.7491039426523, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24650186, Length=334, Percent_Identity=26.0479041916168, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574104, Length=300, Percent_Identity=29.6666666666667, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI18859919, Length=295, Percent_Identity=26.4406779661017, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI221329998, Length=353, Percent_Identity=24.6458923512748, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281360167, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330000, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24585842, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 68718; Mature: 68587

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYPPHAPRPLILSRRRFVQGLAAGGVLLGLSTPALKAAAQQARAASGTAPVLRGTEFD
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCEEE
LVIAESPVNFTGQPGMATTINGSLPAPTLRWREGDTVTIRVTNRLRESTSIHWHGIILPY
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCHHHCCCEEEEEEEEEE
QMDGVPGISFGGIAPGETFTYRFKVSQSGTYWYHSHSGFQEQTGMYGAIIIDPAGPETIR
EECCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCEEEEEECCCCCCCEE
AERDHVVLLTDWTDEDPMRVFMKLKTQGDYYNYHQPTAVDFFRDASREGVSVALDKRKMW
CCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHH
NQMRMSPTDLSDLSAQTLTYLANGTTPAGNWTGLFRPGERVRLRFINGAGNTFYDVRIPG
HHHCCCCCCHHHCCHHEEEEEECCCCCCCCCEEECCCCCEEEEEEEECCCCEEEEEEECC
LKLKVVHVDGVDVEPVTVDEFRFGPGETCDVLVEPHDDAYTIFAQSMDRTGYARGTLAVR
EEEEEEEECCCCCCCEEHHCEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEEEE
AGLSAPVPPMDAAPWLSMADMMGAMDHGDMAGMAGMSGMAGMDHGSMAGMDHGAMAGMDH
ECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GSMQGMTGMSGMTGMDSGQMQGMDSTNPLAVPSTTVRHARTEYGPGTDMRVDMPRTALDD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHCCCCCCCCEEEECCCCCCCC
PGIGLRNNGRRVLTLADLHTPGGPMDPRGPGREVELHLTGNMERYTWSIDGLEFSKSKPV
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCE
HFRHGERLRVILHNDTMMTHPMHLHGMWSELESPDGRFLARRHTLPVQPAQRLSFLVTAD
EEECCCEEEEEEECCEEEECCEEEEECHHHHCCCCCCEEEEECCCCCCHHHHEEEEEEHH
ALGRWAWHCHLMLHMDAGMFREVVVS
HHCCEEEEEEEEEEECCCHHHHHHCC
>Mature Secondary Structure 
TRYPPHAPRPLILSRRRFVQGLAAGGVLLGLSTPALKAAAQQARAASGTAPVLRGTEFD
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEECCEEE
LVIAESPVNFTGQPGMATTINGSLPAPTLRWREGDTVTIRVTNRLRESTSIHWHGIILPY
EEEECCCCCCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCHHHCCCEEEEEEEEEE
QMDGVPGISFGGIAPGETFTYRFKVSQSGTYWYHSHSGFQEQTGMYGAIIIDPAGPETIR
EECCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHCCCEEEEEECCCCCCCEE
AERDHVVLLTDWTDEDPMRVFMKLKTQGDYYNYHQPTAVDFFRDASREGVSVALDKRKMW
CCCCCEEEEECCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHH
NQMRMSPTDLSDLSAQTLTYLANGTTPAGNWTGLFRPGERVRLRFINGAGNTFYDVRIPG
HHHCCCCCCHHHCCHHEEEEEECCCCCCCCCEEECCCCCEEEEEEEECCCCEEEEEEECC
LKLKVVHVDGVDVEPVTVDEFRFGPGETCDVLVEPHDDAYTIFAQSMDRTGYARGTLAVR
EEEEEEEECCCCCCCEEHHCEECCCCCCEEEEECCCCCEEEEEEECCCCCCCCCEEEEEE
AGLSAPVPPMDAAPWLSMADMMGAMDHGDMAGMAGMSGMAGMDHGSMAGMDHGAMAGMDH
ECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GSMQGMTGMSGMTGMDSGQMQGMDSTNPLAVPSTTVRHARTEYGPGTDMRVDMPRTALDD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHCCCCCCCCEEEECCCCCCCC
PGIGLRNNGRRVLTLADLHTPGGPMDPRGPGREVELHLTGNMERYTWSIDGLEFSKSKPV
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCE
HFRHGERLRVILHNDTMMTHPMHLHGMWSELESPDGRFLARRHTLPVQPAQRLSFLVTAD
EEECCCEEEEEEECCEEEECCEEEEECHHHHCCCCCCEEEEECCCCCCHHHHEEEEEEHH
ALGRWAWHCHLMLHMDAGMFREVVVS
HHCCEEEEEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]