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The map label for this gene is trxC [C]

Identifier: 161525474

GI number: 161525474

Start: 2517556

End: 2517993

Strand: Direct

Name: trxC [C]

Synonym: Bmul_2304

Alternate gene names: 161525474

Gene position: 2517556-2517993 (Clockwise)

Preceding gene: 161525473

Following gene: 161525475

Centisome position: 73.01

GC content: 62.79

Gene sequence:

>438_bases
ATGAAGAATGATCTTCACCTCGTCTGTCCGCATTGCCAGTCCATCAACCGCGTACCGACTGCGAAGCTATCGGAACATCC
CAACTGCGGCCGCTGCCAGCAGCCCTTGTTCACGGGCGAACCCATCGAGTTGACCACGGCGACGTTCTCGCGCCACGTGG
AGCGCAGTGACCTGCCACTGTTGGTCGATTTCTGGGCACCTTGGTGCGGGCCGTGCAAGATGATGGCCCCGCAGTTCCAG
CAAGCGGCGCGCCAGCTCGAACCCAGGGTCAGGCTGGCCAAGGTGAATACCGAGGCCGAGCCTCACCTGGCCGCCCAGTT
CGGTATTCGCAGCATTCCAACCCTGATTTTGTTCCGAGGGGGACATGAGGTTGCACGTCAGGCGGGCGCCATGGGCGCGC
AGGACATGGTGCGCTGGGTGGCATCCCGCTTGTCGTGA

Upstream 100 bases:

>100_bases
GTAAGCAAAGACGGGAACGATTGGCTCCAAGGCGTTGATTGGTCGGCATTGTCTGTGACCCGAAGCGCGGCAGCCTCACT
GTGGTCCAAGGAGGCGAACC

Downstream 100 bases:

>100_bases
TAACCCGGCGCGAACCACCCTGCTTATCAGTTGTTCGATCCTTGAAGAAAGTGCGTAGACGCGATGCATAGCGACCCCAA
CCACACAATCTTTGACGAAA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKNDLHLVCPHCQSINRVPTAKLSEHPNCGRCQQPLFTGEPIELTTATFSRHVERSDLPLLVDFWAPWCGPCKMMAPQFQ
QAARQLEPRVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQAGAMGAQDMVRWVASRLS

Sequences:

>Translated_145_residues
MKNDLHLVCPHCQSINRVPTAKLSEHPNCGRCQQPLFTGEPIELTTATFSRHVERSDLPLLVDFWAPWCGPCKMMAPQFQ
QAARQLEPRVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQAGAMGAQDMVRWVASRLS
>Mature_145_residues
MKNDLHLVCPHCQSINRVPTAKLSEHPNCGRCQQPLFTGEPIELTTATFSRHVERSDLPLLVDFWAPWCGPCKMMAPQFQ
QAARQLEPRVRLAKVNTEAEPHLAAQFGIRSIPTLILFRGGHEVARQAGAMGAQDMVRWVASRLS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI20070125, Length=89, Percent_Identity=42.6966292134831, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4758304, Length=94, Percent_Identity=42.5531914893617, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI5031973, Length=77, Percent_Identity=38.961038961039, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI21361657, Length=98, Percent_Identity=36.734693877551, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI224493972, Length=108, Percent_Identity=31.4814814814815, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI42794771, Length=108, Percent_Identity=31.4814814814815, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI24308127, Length=76, Percent_Identity=38.1578947368421, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI94966757, Length=91, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5803121, Length=95, Percent_Identity=33.6842105263158, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=44.2857142857143, Blast_Score=140, Evalue=3e-35,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=39.4230769230769, Blast_Score=97, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17549970, Length=107, Percent_Identity=37.3831775700935, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=106, Percent_Identity=32.0754716981132, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=101, Percent_Identity=28.7128712871287, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507915, Length=105, Percent_Identity=35.2380952380952, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25144092, Length=85, Percent_Identity=37.6470588235294, Blast_Score=72, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI193209454, Length=83, Percent_Identity=37.3493975903614, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=103, Percent_Identity=33.9805825242718, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=83, Percent_Identity=37.3493975903614, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=83, Percent_Identity=37.3493975903614, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=36.046511627907, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=90, Percent_Identity=34.4444444444444, Blast_Score=68, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=88, Percent_Identity=34.0909090909091, Blast_Score=67, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17647799, Length=87, Percent_Identity=43.6781609195402, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19921434, Length=106, Percent_Identity=37.7358490566038, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=108, Percent_Identity=35.1851851851852, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24639826, Length=66, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 16223; Mature: 16223

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDLHLVCPHCQSINRVPTAKLSEHPNCGRCQQPLFTGEPIELTTATFSRHVERSDLPL
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCE
LVDFWAPWCGPCKMMAPQFQQAARQLEPRVRLAKVNTEAEPHLAAQFGIRSIPTLILFRG
EEECCCCCCCCHHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCHHHCCEEEEECC
GHEVARQAGAMGAQDMVRWVASRLS
CHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKNDLHLVCPHCQSINRVPTAKLSEHPNCGRCQQPLFTGEPIELTTATFSRHVERSDLPL
CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCE
LVDFWAPWCGPCKMMAPQFQQAARQLEPRVRLAKVNTEAEPHLAAQFGIRSIPTLILFRG
EEECCCCCCCCHHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCHHHCCEEEEECC
GHEVARQAGAMGAQDMVRWVASRLS
CHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]