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The map label for this gene is fumC [H]

Identifier: 161525383

GI number: 161525383

Start: 2428238

End: 2429632

Strand: Direct

Name: fumC [H]

Synonym: Bmul_2213

Alternate gene names: 161525383

Gene position: 2428238-2429632 (Clockwise)

Preceding gene: 161525382

Following gene: 161525386

Centisome position: 70.42

GC content: 67.74

Gene sequence:

>1395_bases
ATGAACGAAGCAGTCCGGATGGAACGCGACACGTTCGGCGAGATCGCCGTCCCGGCCGACCGGCTCTGGGGCGCGCAAAC
CGAGCGCTCGCTGCAGAATTTCCGGATCTCGACGGAAAAGCAGTCGCCCGAGCTGATTCATGCGCTGGCGATCGTCAAGC
GCGCGGCGGCGGCCGTGAACCAGTCGCTCGGCGTGCTCGCCGACGACAAGGCGCAGGCGATCATCGCCGCGGCCGACGAG
ATCATCGCCGGCAAGCATGCGCGCGAATTCCCGCTCGCGGTCTGGCAGACGGGCTCCGGCACGCAGACCAACATGAACCT
GAACGAGGTGATCGCGAACCGCGCGAGCGAGCTGATGGGCGGCGAGCGCGGCGAAGCGCGCAAGGTTCATCCGAACGACG
ACGTCAACCGCGGCCAGTCGTCGAACGACGTGTTCCCGACCGCGATGCACGTCGCGGCCGCGTACGCGATCGTCAACCAT
CTGCTGCCCGCGCTGCGCACGCTGCGCGCAACGCTCGACGCGAAGTCGAAGGCGTTCGCCGACATCGTGAAGATCGGCCG
CACGCACCTGCAGGACGCGACGCCGCTCACGCTGGGCCAGGAATTCTCGGGCTACGTCGCGCAGCTCGACCAGGGCATCC
GGCATGTCGAATCAGCGCTGCCGCATCTGTACGAGCTCGCGCTCGGCGGCACCGCGGTCGGCACCGGGCTGAACGCGCAT
CCGGAATTCGCGGCGCGCGTGGCCGGCGAGATCGGCCGCCTGACGAAGCTGCCGTTCGTCACGGCGCCGAACAAGTTCGA
GGTGATGGCGGCCGCCGACGCGCTGGTGTTCGCGCACGGCGCGCTGAAGACCGTCGCGGCGGGCCTGATGAAGATCGCGA
ACGACGTGCGCTGGCTCGCGAGCGGCCCGCGCTGCGGGCTCGGCGAACTGTCGATTCCCGAAAACGAGCCCGGCAGCTCG
ATCATGCCGGGCAAGGTCAATCCGACGCAGTCGGAAGCCGTCACGATGCTGTGCTGCCAGGTGTTCGGCAACGACGTCGC
GGTGAACGTCGGCGGCGCAAGCGGCAATTTCGAGCTGAACGTGTTCCGGCCGATGATCGCGCACAACGTGCTGCAGTCGG
TGCGGTTGCTCGCGGACGGCGCGCAGAGCTTCAACGATCACTGCGCGGTGGGCATCGAGCCGAACCGCGCGCGCATCGAT
CTGCTGCTGAACGAATCGCTGATGCTCGTGACCGCGCTCAATCCGCACATCGGCTACGACAAGGCCGCGCAGATCGCGAA
AAAGGCGCACAAGGAAGGCACGACGCTGAAGGCCGCCGCGCTGGCGCTCGGCTATCTGACCGAGGCGGAATTCGACGAGT
GGGTCAGGCCGGAGCAGATGGTCGGCACGCGCTGA

Upstream 100 bases:

>100_bases
TCGCGGCCGGCGCTATGCTTGTCGCCTGAACACCCACACGCCTCACGATACGCCCTCGCCGCGCGCCGCGCGGCCTTCCC
CTTTTCTCGAGGAGTGCATC

Downstream 100 bases:

>100_bases
GCGTCGGCCCGCGCGGCGCGATGCAAACGGGGGCGCACGCGCCCCCGCGTCGTCACACTTCGCCCTTCGCGACCTCTTCC
GGCTTCATCTCGACGATCTT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAQAIIAAADE
IIAGKHAREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAARVAGEIGRLTKLPFVTAPNKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRARID
LLLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYLTEAEFDEWVRPEQMVGTR

Sequences:

>Translated_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAQAIIAAADE
IIAGKHAREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAARVAGEIGRLTKLPFVTAPNKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRARID
LLLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYLTEAEFDEWVRPEQMVGTR
>Mature_464_residues
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVNQSLGVLADDKAQAIIAAADE
IIAGKHAREFPLAVWQTGSGTQTNMNLNEVIANRASELMGGERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNH
LLPALRTLRATLDAKSKAFADIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
PEFAARVAGEIGRLTKLPFVTAPNKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLASGPRCGLGELSIPENEPGSS
IMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELNVFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRARID
LLLNESLMLVTALNPHIGYDKAAQIAKKAHKEGTTLKAAALALGYLTEAEFDEWVRPEQMVGTR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=464, Percent_Identity=63.1465517241379, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI266458395, Length=66, Percent_Identity=50, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=76.4705882352941, Blast_Score=724, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=456, Percent_Identity=40.3508771929825, Blast_Score=345, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=63.4989200863931, Blast_Score=598, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=66.5644171779141, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6324993, Length=466, Percent_Identity=59.2274678111588, Blast_Score=563, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640179, Length=467, Percent_Identity=61.2419700214133, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640177, Length=467, Percent_Identity=61.2419700214133, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=59.9137931034483, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=60.6060606060606, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=53.5791757049892, Blast_Score=494, Evalue=1e-140,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49601; Mature: 49601

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKAQAIIAAADEIIAGKHAREFPLAVWQTGSGTQTNMNLNEVIANRASELMG
HCCCCEECCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNHLLPALRTLRATLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAARVAGEIGRLTKLPFVTAPNKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLA
HHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRARIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLKAAALALGYLTEAEFDEWVRPEQMVGTR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
>Mature Secondary Structure
MNEAVRMERDTFGEIAVPADRLWGAQTERSLQNFRISTEKQSPELIHALAIVKRAAAAVN
CCCCHHCCCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
QSLGVLADDKAQAIIAAADEIIAGKHAREFPLAVWQTGSGTQTNMNLNEVIANRASELMG
HCCCCEECCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GERGEARKVHPNDDVNRGQSSNDVFPTAMHVAAAYAIVNHLLPALRTLRATLDAKSKAFA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIVKIGRTHLQDATPLTLGQEFSGYVAQLDQGIRHVESALPHLYELALGGTAVGTGLNAH
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCC
PEFAARVAGEIGRLTKLPFVTAPNKFEVMAAADALVFAHGALKTVAAGLMKIANDVRWLA
HHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGLGELSIPENEPGSSIMPGKVNPTQSEAVTMLCCQVFGNDVAVNVGGASGNFELN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEE
VFRPMIAHNVLQSVRLLADGAQSFNDHCAVGIEPNRARIDLLLNESLMLVTALNPHIGYD
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCCEEEEEECCCCCCCH
KAAQIAKKAHKEGTTLKAAALALGYLTEAEFDEWVRPEQMVGTR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]