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The map label for this gene is cynR [H]

Identifier: 161524819

GI number: 161524819

Start: 1821510

End: 1822463

Strand: Reverse

Name: cynR [H]

Synonym: Bmul_1646

Alternate gene names: 161524819

Gene position: 1822463-1821510 (Counterclockwise)

Preceding gene: 161524822

Following gene: 161524818

Centisome position: 52.85

GC content: 69.92

Gene sequence:

>954_bases
ATGGCGGCTTTTCTGCATGGCCTGGCACTGCGGTATTTCGTCGAAGTCGCCCGTACGGGCTCGCTCAGCGACGCGTCGGC
GCGGCTGCATGTCGCCGTGTCGGCGATCAGCCGGCAGATCGCAAAGCTCGAAAGCGAGCTCGGCGCGCCGCTGTTCGAGC
GACGGCCGCGCGGCATGGCGCTGTCGGAGGCGGGCGAGCGGCTGCTCGGCTTCGCGCAGCGCAGCCTGCTCGAAGCCGAA
CACGTGATGAAGGAGATCGGCGGGCTCGACGCGCTGCACGGCAGCCTGTTGAAGATCGCCTGCTCGGAAGGGTTCGCGAT
CGACTTCCTGCCCGGCGCGCTGGCAACGTTCAAGGCGCGCCATCCGGGCGTCGATTTTTCGGTGTGGGTCGTGTCGCCGG
CCGATGCGACGCGGCGCGTGCGCGAGGGCGACGCCGACATCGCGCTGACGTTCAGCCTCGCGCCGGAAAAGGGCGTGCGC
GTCGAGCATACGGAGCGCGCGCCGATCTTCGCGCTGCTGCGCCGCGATCATCCGCTCGCGGCGCGCGAGGCCGTATCGCT
CGCCGACGTCGCGCGTCATCCGCACGTGCTGCCCGAAGCCGGCACGACGGTGCGCCAGCTGATCGACATCGCATGCGCGC
TGGACGGCCTGATGCTCGAGCCGGAACTCACGAGCAACAACACGGCCGCGATGTACCGCTACGCGCAGCGTACGGGCGCG
GTGATGTTCTCCGGCCTGCTATCGGTGCGCGACCGCTGCGACGCCGACGGCTTCGTCGTCGTGCCGGTCACGAACCCGCA
GTTGCGCGAACGCAGCATCCAGGTACAGACGATGGCGGGGCGCGATCTGCCGGCATCGGTGCGCGCGTTTCGCGATCATC
TGATCGACGCGATGAAGGCCGCGTCGGTGCCGCCGAACGCGGCGCGCGGCTCGCGGCGCCCGCGCGTGAGATAA

Upstream 100 bases:

>100_bases
TTCTAGAAAGCCGTTTTTTTTGTCACAATGATCGAATTTCGAAGCTTTCTTTGCCGAAAAGGCAAAGCAGGACGGCCGCT
CGCGGCACGGAGACAGAACG

Downstream 100 bases:

>100_bases
TTGCAGGTCCGCCTTCCTGCGCCCGTGCGGCTCGCCGAGCCGCACCGACCCGTTTCGACGCCAAATTGAAGAACCTGATT
GTCACCCTCGATCGCGCCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MAAFLHGLALRYFVEVARTGSLSDASARLHVAVSAISRQIAKLESELGAPLFERRPRGMALSEAGERLLGFAQRSLLEAE
HVMKEIGGLDALHGSLLKIACSEGFAIDFLPGALATFKARHPGVDFSVWVVSPADATRRVREGDADIALTFSLAPEKGVR
VEHTERAPIFALLRRDHPLAAREAVSLADVARHPHVLPEAGTTVRQLIDIACALDGLMLEPELTSNNTAAMYRYAQRTGA
VMFSGLLSVRDRCDADGFVVVPVTNPQLRERSIQVQTMAGRDLPASVRAFRDHLIDAMKAASVPPNAARGSRRPRVR

Sequences:

>Translated_317_residues
MAAFLHGLALRYFVEVARTGSLSDASARLHVAVSAISRQIAKLESELGAPLFERRPRGMALSEAGERLLGFAQRSLLEAE
HVMKEIGGLDALHGSLLKIACSEGFAIDFLPGALATFKARHPGVDFSVWVVSPADATRRVREGDADIALTFSLAPEKGVR
VEHTERAPIFALLRRDHPLAAREAVSLADVARHPHVLPEAGTTVRQLIDIACALDGLMLEPELTSNNTAAMYRYAQRTGA
VMFSGLLSVRDRCDADGFVVVPVTNPQLRERSIQVQTMAGRDLPASVRAFRDHLIDAMKAASVPPNAARGSRRPRVR
>Mature_316_residues
AAFLHGLALRYFVEVARTGSLSDASARLHVAVSAISRQIAKLESELGAPLFERRPRGMALSEAGERLLGFAQRSLLEAEH
VMKEIGGLDALHGSLLKIACSEGFAIDFLPGALATFKARHPGVDFSVWVVSPADATRRVREGDADIALTFSLAPEKGVRV
EHTERAPIFALLRRDHPLAAREAVSLADVARHPHVLPEAGTTVRQLIDIACALDGLMLEPELTSNNTAAMYRYAQRTGAV
MFSGLLSVRDRCDADGFVVVPVTNPQLRERSIQVQTMAGRDLPASVRAFRDHLIDAMKAASVPPNAARGSRRPRVR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=305, Percent_Identity=29.1803278688525, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI145693105, Length=201, Percent_Identity=24.3781094527363, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788748, Length=214, Percent_Identity=27.1028037383178, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790208, Length=143, Percent_Identity=36.3636363636364, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=26.2798634812287, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788296, Length=235, Percent_Identity=28.0851063829787, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787530, Length=236, Percent_Identity=28.3898305084746, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790262, Length=182, Percent_Identity=27.4725274725275, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788887, Length=186, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789204, Length=205, Percent_Identity=27.8048780487805, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=207, Percent_Identity=27.0531400966184, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=202, Percent_Identity=27.7227722772277, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788297, Length=215, Percent_Identity=26.5116279069767, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=31.1475409836066, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789173, Length=159, Percent_Identity=33.9622641509434, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=119, Percent_Identity=35.2941176470588, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34379; Mature: 34248

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAFLHGLALRYFVEVARTGSLSDASARLHVAVSAISRQIAKLESELGAPLFERRPRGMA
CHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
LSEAGERLLGFAQRSLLEAEHVMKEIGGLDALHGSLLKIACSEGFAIDFLPGALATFKAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCEEEECCCHHHHHHCC
HPGVDFSVWVVSPADATRRVREGDADIALTFSLAPEKGVRVEHTERAPIFALLRRDHPLA
CCCCCEEEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHCCCCHH
AREAVSLADVARHPHVLPEAGTTVRQLIDIACALDGLMLEPELTSNNTAAMYRYAQRTGA
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHH
VMFSGLLSVRDRCDADGFVVVPVTNPQLRERSIQVQTMAGRDLPASVRAFRDHLIDAMKA
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ASVPPNAARGSRRPRVR
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAFLHGLALRYFVEVARTGSLSDASARLHVAVSAISRQIAKLESELGAPLFERRPRGMA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
LSEAGERLLGFAQRSLLEAEHVMKEIGGLDALHGSLLKIACSEGFAIDFLPGALATFKAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCCEEEECCCHHHHHHCC
HPGVDFSVWVVSPADATRRVREGDADIALTFSLAPEKGVRVEHTERAPIFALLRRDHPLA
CCCCCEEEEEECCCHHHHHHHCCCCCEEEEEEECCCCCCEEECCCCCHHHHHHHCCCCHH
AREAVSLADVARHPHVLPEAGTTVRQLIDIACALDGLMLEPELTSNNTAAMYRYAQRTGA
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHH
VMFSGLLSVRDRCDADGFVVVPVTNPQLRERSIQVQTMAGRDLPASVRAFRDHLIDAMKA
HHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHH
ASVPPNAARGSRRPRVR
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]