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The map label for this gene is norM [H]

Identifier: 161524611

GI number: 161524611

Start: 1582348

End: 1583709

Strand: Reverse

Name: norM [H]

Synonym: Bmul_1438

Alternate gene names: 161524611

Gene position: 1583709-1582348 (Counterclockwise)

Preceding gene: 161524612

Following gene: 161524604

Centisome position: 45.93

GC content: 70.78

Gene sequence:

>1362_bases
TTGACGATGTTCGCGGACATCCGTCGCATCGTCGGTCTCGCGTGGCCGGTGCTCGTCGGCCAGCTCGCGATCATCGCGTT
CGGCGTGATCGACACCGCGATGGTCGGCCGCTACTCGGCCGTCGACCTCGCCGCGCTCGGGCTCGGCTCGTCGATCTACG
TGTCCGTCTATATCGGGCTGACCGGCATCCTGTCCGCGCTGCAGCCGATCGCGGGCCAGCTGTACGGCGCGCGGCGCTAT
GCCGAGATCGGCGAGGAAGTGCGCCAGGCGCTGTGGCTCGCCGTGCTGCTCGCGACGCCCGGCTTCCTGCTGCTGCATTT
TCCCGAACCGCTGCTGCGCGTCGCGCACGCGCCGCCCGCGCTTCACGACCGCACCGTCGACTATCTGCGCATCCTGTCGT
ACGGGCTGCCGGCGAGCCTCGTGTTCCGCATCTATAACGCGCTGACCAACGCGGCCGGCAAGCCGCGGCTCGCGATGATC
CTGCAGATCGGCGCACTGCTGCTGAAGGTCCCGCTCAACGTGTGGTTCATCTTCGGCGGCTTCGGCGTACCGGCGCTCGG
CGGCCCCGGCTGCGGGCTCGCCAGCACGCTGATCAACTGGGCGCTCGCGCTGATCGGCTTCGCGCTGCTCGCGCGCCTCG
ACGTGTTCGCGCCGCTCGCGATCTTCTCGCGCTTCTGCTGGCCCGTCTGGGCGCGCCAGAAGGCGCTGCTGAAGCTGGGC
GTGCCGATGGGGCTGTCCTACCTGATCGAAGTCACGTCGTACACCTGCATGGCGCTGTTCATCGCGCAGTTCGGCACGAC
GACGCTGGCCGGCCACCAGATCGCCGGCAACGTCGGCGCCGTGCTGTACATGACGCCGCTGTCGATCGGCGTCGCTGCGT
CCACGCTCGTCGCACGCGCGCTCGGTGCGGGCCGGCCCGACGAAGCGCGGCTGCTGGGCCGGCACGGCGTGATCCTCGCC
TGCGCGATCGCGGCCGCGTACGGCCTGCTCGTGTTCGTGCTGCGGCCGCTGATCATCGGCGGCTACACGCCGAATCCGGC
CGTCGCGGCCGCCGCGATGCCGCTCGTCGCGATCGTCACCTGCTACCACTTCTTCGACGCGCTGCAGATCACCTCCGCGT
TCGTGCTGCGCGCGTACAAGGTCGCGGTCGTGCCGACCGTGATCTACGCGGTCGCGCTCTGGGGCGTCGGCCTCGGCGGC
GGCTATCTGCTCGGCTTCGACGTCGGCGGCATCGCGCCCGCGTGGGTCGTCGGCGCGCGCGGCTTCTGGTTCGCGAACAC
GGTCAGCCTGATGCTCGCGGGCGTCGGGCTCGCGCTGTACCTGCGCCGCGTGAGCCGCCTGCACGTGTCCGCCGGCGCCT
GA

Upstream 100 bases:

>100_bases
GCCGCGTCGCCGACCGCGACGAGCGCTTCCGCCTGTACGAGCGCATCGAACGGCCGAAGACGCCGGTCAAGCGGCGCGCG
CCGCATCGCCGGGCGGCCGG

Downstream 100 bases:

>100_bases
GCCGCGGCCCGCTACGCGGGCACCAGCACGTCGGCCGCGTGATACGACGAGCGCACGAGCGGGCCGGCGACCACCTCCGC
GAAACCGAGCGCGAGCCCTT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTMFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSVYIGLTGILSALQPIAGQLYGARRY
AEIGEEVRQALWLAVLLATPGFLLLHFPEPLLRVAHAPPALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMI
LQIGALLLKVPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGFALLARLDVFAPLAIFSRFCWPVWARQKALLKLG
VPMGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHGVILA
CAIAAAYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGG
GYLLGFDVGGIAPAWVVGARGFWFANTVSLMLAGVGLALYLRRVSRLHVSAGA

Sequences:

>Translated_453_residues
MTMFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSVYIGLTGILSALQPIAGQLYGARRY
AEIGEEVRQALWLAVLLATPGFLLLHFPEPLLRVAHAPPALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMI
LQIGALLLKVPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGFALLARLDVFAPLAIFSRFCWPVWARQKALLKLG
VPMGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHGVILA
CAIAAAYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGG
GYLLGFDVGGIAPAWVVGARGFWFANTVSLMLAGVGLALYLRRVSRLHVSAGA
>Mature_452_residues
TMFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSVYIGLTGILSALQPIAGQLYGARRYA
EIGEEVRQALWLAVLLATPGFLLLHFPEPLLRVAHAPPALHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMIL
QIGALLLKVPLNVWFIFGGFGVPALGGPGCGLASTLINWALALIGFALLARLDVFAPLAIFSRFCWPVWARQKALLKLGV
PMGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVAASTLVARALGAGRPDEARLLGRHGVILAC
AIAAAYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVTCYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGG
YLLGFDVGGIAPAWVVGARGFWFANTVSLMLAGVGLALYLRRVSRLHVSAGA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=424, Percent_Identity=24.0566037735849, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI48994890, Length=444, Percent_Identity=32.2072072072072, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI226510954, Length=434, Percent_Identity=24.1935483870968, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320545, Length=411, Percent_Identity=25.5474452554745, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321821, Length=333, Percent_Identity=21.3213213213213, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47785; Mature: 47653

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSVYIGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
TGILSALQPIAGQLYGARRYAEIGEEVRQALWLAVLLATPGFLLLHFPEPLLRVAHAPPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCC
LHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKVPLNVWFIFGG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
FGVPALGGPGCGLASTLINWALALIGFALLARLDVFAPLAIFSRFCWPVWARQKALLKLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VPMGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVAASTLVARA
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCEEEEECHHHHHHHHHHHHHHH
LGAGRPDEARLLGRHGVILACAIAAAYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVT
HCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
CYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGYLLGFDVGGIAPAWVVGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCC
GFWFANTVSLMLAGVGLALYLRRVSRLHVSAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TMFADIRRIVGLAWPVLVGQLAIIAFGVIDTAMVGRYSAVDLAALGLGSSIYVSVYIGL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHH
TGILSALQPIAGQLYGARRYAEIGEEVRQALWLAVLLATPGFLLLHFPEPLLRVAHAPPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCC
LHDRTVDYLRILSYGLPASLVFRIYNALTNAAGKPRLAMILQIGALLLKVPLNVWFIFGG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEC
FGVPALGGPGCGLASTLINWALALIGFALLARLDVFAPLAIFSRFCWPVWARQKALLKLG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VPMGLSYLIEVTSYTCMALFIAQFGTTTLAGHQIAGNVGAVLYMTPLSIGVAASTLVARA
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHCCCCCEEEEECHHHHHHHHHHHHHHH
LGAGRPDEARLLGRHGVILACAIAAAYGLLVFVLRPLIIGGYTPNPAVAAAAMPLVAIVT
HCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
CYHFFDALQITSAFVLRAYKVAVVPTVIYAVALWGVGLGGGYLLGFDVGGIAPAWVVGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHCCC
GFWFANTVSLMLAGVGLALYLRRVSRLHVSAGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA