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The map label for this gene is hdaH [H]

Identifier: 161524514

GI number: 161524514

Start: 1472382

End: 1473503

Strand: Reverse

Name: hdaH [H]

Synonym: Bmul_1341

Alternate gene names: 161524514

Gene position: 1473503-1472382 (Counterclockwise)

Preceding gene: 161524515

Following gene: 161524513

Centisome position: 42.73

GC content: 69.88

Gene sequence:

>1122_bases
ATGAAACGCACCGCATTCTTCACCGACGAACGCACCTTCTGGCACACAGGCGGCACGCACGCGCTGTTCTTTCCGGTCGG
CGGCTGGGTCCAGCCGCCGTCGGGCGCCGGTTATGCGGAATCGCCCGATTCGAAGCGCCGGCTGCTGTCGCTCGTGCACG
CGTCGGGGCTCGCCGCGCAGCTCGACATGCGTGGCGCCGCGCCTGCCGCACGCGACGATCTGCTGCGCATCCACCCTGCC
GGCTACCTCGATGCATTTCGTGCGCTCAGCGACGCGAACGGCGGCGACCTCGGCGATCTCGCGCCGTTCGGCAAGGGCAG
CTATGAAATCGCCGCATTATCGGCCGGGCTCGCGATCGCAGCGGTCGACGCGGTCGTTGCCGAGCGCGCAGCGAACGCGT
TCTCGCTGTCGCGCCCGCCCGGCCATCATTGCCTGCGCGACCGGCCGATGGGCTTCTGCCTGCTCGCCAACATCCCGATC
GCGATCGAGGCCGCACGCGCGAAGCACGGCATCGGCCGCGTGGCCGTGATCGACTGGGACGTGCATCACGGCAACGGCAC
GCAGTCGATCTATTACGACGACCCGGACACGCTGACGATCTCGCTGCATCAGGACCGCTGCTTCCCGCCCGGCTACGGCG
GCGCCGAGGATCGCGGCGCCGGTGCGGGCGTCGGCGCGAACCTGAACGTGCCGCTGCTCGCCGGCAGCGGCGACGATGCG
TACCGCCATGCGTTCGAGCGGATCGTGCTGCCGGCGCTCGAGCGCTTCCGGCCCGAACTGATCGTCGTCGCGAGCGGGCT
CGATGCGAGCGCGGTCGATCCGCTCGCGCGGATGCAGCTGCATACCGACAGCTACCGGTTCATGACGCGCGCCGTCAAGG
AAGCCGCGCAGCGCCATTGCGGCGGCCGGCTCGTGATCGTGCACGAAGGCGGCTATTCGGAAGCGTACGTGCCGTTCTGC
GGACTCGCGATCGTCGAGGAGCTGGCCGGCGTTCGCACGGCGGTCGCCGATCCGATGCTCGAGCTCGCGGTGGCGCAACA
GCCCGGCGAGCGGTTCGTCGCGTTCCAGCGCACGCTGATCGACGAACTGGCGGCATCGTTCGGACTGCCGGCCGCGCGAT
GA

Upstream 100 bases:

>100_bases
CGCCGCGACCGCGGTCGCCGTCGTGTCGTTCGCCGCGCTGCGCGGCATCGAACGGTCGGCACGCCGTTCCGCTTCTTCCC
AACCTTGACAGGTCATGCCC

Downstream 100 bases:

>100_bases
CGGCAGCGGGCCGGCGTCGGCTCGCGGCCGGCCCTTGCGCGATCGGCGCGGATGCGGTCTCCTGTGCGTTTGATCACACA
GGTCCGAGGCCGTCCTCATC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSGAGYAESPDSKRRLLSLVHASGLAAQLDMRGAAPAARDDLLRIHPA
GYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIAAVDAVVAERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIGRVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYGGAEDRGAGAGVGANLNVPLLAGSGDDA
YRHAFERIVLPALERFRPELIVVASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTAVADPMLELAVAQQPGERFVAFQRTLIDELAASFGLPAAR

Sequences:

>Translated_373_residues
MKRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSGAGYAESPDSKRRLLSLVHASGLAAQLDMRGAAPAARDDLLRIHPA
GYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIAAVDAVVAERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIGRVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYGGAEDRGAGAGVGANLNVPLLAGSGDDA
YRHAFERIVLPALERFRPELIVVASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTAVADPMLELAVAQQPGERFVAFQRTLIDELAASFGLPAAR
>Mature_373_residues
MKRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSGAGYAESPDSKRRLLSLVHASGLAAQLDMRGAAPAARDDLLRIHPA
GYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIAAVDAVVAERAANAFSLSRPPGHHCLRDRPMGFCLLANIPI
AIEAARAKHGIGRVAVIDWDVHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYGGAEDRGAGAGVGANLNVPLLAGSGDDA
YRHAFERIVLPALERFRPELIVVASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHCGGRLVIVHEGGYSEAYVPFC
GLAIVEELAGVRTAVADPMLELAVAQQPGERFVAFQRTLIDELAASFGLPAAR

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=291, Percent_Identity=33.6769759450172, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI153085395, Length=259, Percent_Identity=33.2046332046332, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI20070354, Length=284, Percent_Identity=33.4507042253521, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148539870, Length=251, Percent_Identity=34.6613545816733, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI169234807, Length=251, Percent_Identity=34.6613545816733, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI17158039, Length=265, Percent_Identity=31.3207547169811, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI30795204, Length=259, Percent_Identity=31.6602316602317, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI30795202, Length=259, Percent_Identity=31.6602316602317, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI62750349, Length=257, Percent_Identity=33.852140077821, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI62750347, Length=257, Percent_Identity=33.852140077821, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI226529806, Length=285, Percent_Identity=30.8771929824561, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI13128860, Length=256, Percent_Identity=26.953125, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI293336691, Length=269, Percent_Identity=26.3940520446097, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13128862, Length=257, Percent_Identity=28.4046692607004, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=27.0916334661355, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=28.2511210762332, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI262073088, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI209862883, Length=242, Percent_Identity=26.0330578512397, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI217272877, Length=140, Percent_Identity=30.7142857142857, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=30.42071197411, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=30.42071197411, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=30.42071197411, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI193209491, Length=239, Percent_Identity=33.8912133891213, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=298, Percent_Identity=30.5369127516779, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17561978, Length=299, Percent_Identity=29.0969899665552, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25154020, Length=287, Percent_Identity=27.1777003484321, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=226, Percent_Identity=30.9734513274336, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25154022, Length=287, Percent_Identity=26.4808362369338, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17537347, Length=256, Percent_Identity=30.46875, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324307, Length=275, Percent_Identity=33.0909090909091, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321244, Length=274, Percent_Identity=29.9270072992701, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323999, Length=289, Percent_Identity=29.0657439446367, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325141, Length=273, Percent_Identity=30.03663003663, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=199, Percent_Identity=25.1256281407035, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281360899, Length=334, Percent_Identity=32.9341317365269, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24642142, Length=334, Percent_Identity=32.9341317365269, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642144, Length=337, Percent_Identity=32.6409495548961, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24642146, Length=334, Percent_Identity=32.9341317365269, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281360799, Length=224, Percent_Identity=37.9464285714286, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24641720, Length=224, Percent_Identity=37.9464285714286, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI281360801, Length=224, Percent_Identity=37.9464285714286, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24657891, Length=256, Percent_Identity=30.078125, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644244, Length=274, Percent_Identity=27.7372262773723, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 39684; Mature: 39684

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSGAGYAESPDSKRRLLSLVHASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMRGAAPAARDDLLRIHPAGYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIA
EECCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
AVDAVVAERAANAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIGRVAVIDWD
HHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEEHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYGGAEDRGAGAGVGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRHAFERIVLPALERFRPELIVVASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGVRTAVADPMLELAVAQQPGERFVAFQRTLI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGLPAAR
HHHHHHCCCCCCC
>Mature Secondary Structure
MKRTAFFTDERTFWHTGGTHALFFPVGGWVQPPSGAGYAESPDSKRRLLSLVHASGLAAQ
CCCCEEEECCCEEEECCCCEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEE
LDMRGAAPAARDDLLRIHPAGYLDAFRALSDANGGDLGDLAPFGKGSYEIAALSAGLAIA
EECCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
AVDAVVAERAANAFSLSRPPGHHCLRDRPMGFCLLANIPIAIEAARAKHGIGRVAVIDWD
HHHHHHHHHHCCCEECCCCCCCHHHHCCCCCEEEEECCCEEEEEHHHHCCCCEEEEEEEE
VHHGNGTQSIYYDDPDTLTISLHQDRCFPPGYGGAEDRGAGAGVGANLNVPLLAGSGDDA
EECCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHH
YRHAFERIVLPALERFRPELIVVASGLDASAVDPLARMQLHTDSYRFMTRAVKEAAQRHC
HHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCC
GGRLVIVHEGGYSEAYVPFCGLAIVEELAGVRTAVADPMLELAVAQQPGERFVAFQRTLI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DELAASFGLPAAR
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA