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The map label for this gene is envZ [H]

Identifier: 161524505

GI number: 161524505

Start: 1463752

End: 1465113

Strand: Reverse

Name: envZ [H]

Synonym: Bmul_1332

Alternate gene names: 161524505

Gene position: 1465113-1463752 (Counterclockwise)

Preceding gene: 161524506

Following gene: 161524504

Centisome position: 42.49

GC content: 69.02

Gene sequence:

>1362_bases
ATGCGTATCGACCGGCGCCTTCTGCAGCTCGCGTTCGGCGGGCTGTTCTGGCGCACCTTCCTGCTGATCGCGCTGCTGAT
CTCGGTCAGTCTCGCCGCGTGGTTTCAGAGCTTTCGCGTGATCGAGCGCGAGCCGCGCGCGCAGCGCGTCGCGCTGCAGC
TCGTCGCGATCGTGAAGCTCACGCGCACCGCGCTGCTCTACTCCGATCCCGATCTGCGCCGCGCGCTGCTGCAGGATCTC
GAGAGCAACGAAGGCGTGCGCGTGTACCCGCGCGAGAAGACCGACAAATTCCGGCTGCAGCCCGACGAGTCGCTGAACCG
GCTCATCGAACACGACATCCGCAGCCGCCTCGGCGACGATACCGTGATCGCGCAGTCGGTCAACGACATTCCGGGCGTGT
GGATCAGCTTCAAGATCGACGACGACGACTACTGGGTCGCGCTCGACCGCGATCAGCTCGATACGGTCACGGGCCTGCAG
TGGGCCGGCTGGGGGCTGTTCGCGCTCGCGCTGTCGCTGTTCGGCTCCGCGTTCATCACGAGCCTCGTGAACCGGCCGTT
CTCGCGGCTGGCCCTCGCCGCGCGCCAGGTCGGTTCGGGGCAGGCGCCCGAGCCGCTGCCCGAGCGCGGGATGGGCGTCG
CGGCCGAAACCAACCGCAGCTTCAACCAGATGGTGCGCGACCTCGAGCAGCTCGAGGCCGACCGCGCACTGATGCTCGCC
GGCATTTCGCACGACCTGCGCACGCCGCTCGCGCGGCTGCGTCTCGAAACCGAAATGAGTCCGTCCGACCAGGCGACCAA
GGACGCGATGGTCGACGACATCGAGCAGATGGACCGCATCATCGCCGCCTTCATCGACTACGCGCGGCCGACGCAGCGCA
AGCCCGAGCCCGTCGATCTGTCGACGGTCGCGCAGGACGTGGCCGCGCGCGTGTCGAGCGAGGACGGCGTCGAGATCCGC
CTGCGGCTCGCGCCGGCCGCGATCATCGAGGCCGACGAAACCGACATGCGCCGCGTGGTCGGCAACCTCGTCGAGAACGC
GCGCAAATACGGGCAAAGCAAGCACGACGGCATCTCGCGGATCACGCTCGAGACGCGCGTGTCGCATGCGCGCGTCGAGC
TGTCGGTCAGCGACGAAGGCCCCGGCATTCCCGAAGATCAGCTGCCGCTCGTGATGCGGCCGTTCTACCGCGTCGACACC
GCGCGCTCGAAGGCCGACGGCACCGGCCTCGGGATGGCGATCGTGCTGCGCCTCGTCGGCCGCTATCGCGGCACGCTGCG
CCTGCGCAACCGCAGCCCCGAAGCGGGGCTCGAAGTCACGCTCGAATTCCCCGGCACCGGCAAGGCGCGCGCGACCGCAT
GA

Upstream 100 bases:

>100_bases
CGCTTCATCCAGACCGTCTGGGGTCTCGGCTACGTGTTCATCCCGGACGGCGCCGCCTGATCGTCCTTCCTTCCGGTTTC
GCCCGCTCACGGCCCGTCCC

Downstream 100 bases:

>100_bases
CGCGGGCGCGCACGTTTATTGCGCGTCACACTATCGCCGCGGTTGAGAAAATCTATGGGGAGTGTTAGTCAAAATCTATT
GAATCGCTTCACTAATAGTG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFRLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPTQRKPEPVDLSTVAQDVAARVSSEDGVEIR
LRLAPAAIIEADETDMRRVVGNLVENARKYGQSKHDGISRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARSKADGTGLGMAIVLRLVGRYRGTLRLRNRSPEAGLEVTLEFPGTGKARATA

Sequences:

>Translated_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFRLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPTQRKPEPVDLSTVAQDVAARVSSEDGVEIR
LRLAPAAIIEADETDMRRVVGNLVENARKYGQSKHDGISRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARSKADGTGLGMAIVLRLVGRYRGTLRLRNRSPEAGLEVTLEFPGTGKARATA
>Mature_453_residues
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKLTRTALLYSDPDLRRALLQDL
ESNEGVRVYPREKTDKFRLQPDESLNRLIEHDIRSRLGDDTVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQ
WAGWGLFALALSLFGSAFITSLVNRPFSRLALAARQVGSGQAPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPTQRKPEPVDLSTVAQDVAARVSSEDGVEIR
LRLAPAAIIEADETDMRRVVGNLVENARKYGQSKHDGISRITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDT
ARSKADGTGLGMAIVLRLVGRYRGTLRLRNRSPEAGLEVTLEFPGTGKARATA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=443, Percent_Identity=32.5056433408578, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1787894, Length=268, Percent_Identity=31.7164179104478, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=28.2608695652174, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788393, Length=282, Percent_Identity=29.0780141843972, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786600, Length=218, Percent_Identity=29.8165137614679, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=29.6803652968037, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786783, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=27.8169014084507, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=30.2127659574468, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=25.4098360655738, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=27.0642201834862, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=319, Percent_Identity=24.4514106583072, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=285, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=24.3243243243243, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=233, Percent_Identity=27.4678111587983, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789149, Length=214, Percent_Identity=28.5046728971963, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.8481012658228, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50652; Mature: 50652

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFRLQPDESLNRLIEHDIRSRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQVGSGQAPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPTQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
STVAQDVAARVSSEDGVEIRLRLAPAAIIEADETDMRRVVGNLVENARKYGQSKHDGISR
HHHHHHHHHHCCCCCCCEEEEEECCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
ITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDTARSKADGTGLGMAIVLRLVG
EEHHHHHCEEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHH
RYRGTLRLRNRSPEAGLEVTLEFPGTGKARATA
HHCCEEEECCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MRIDRRLLQLAFGGLFWRTFLLIALLISVSLAAWFQSFRVIEREPRAQRVALQLVAIVKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
TRTALLYSDPDLRRALLQDLESNEGVRVYPREKTDKFRLQPDESLNRLIEHDIRSRLGDD
HHHHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
TVIAQSVNDIPGVWISFKIDDDDYWVALDRDQLDTVTGLQWAGWGLFALALSLFGSAFIT
HHHHHHHCCCCCEEEEEEECCCCEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SLVNRPFSRLALAARQVGSGQAPEPLPERGMGVAAETNRSFNQMVRDLEQLEADRALMLA
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHCHHHHHH
GISHDLRTPLARLRLETEMSPSDQATKDAMVDDIEQMDRIIAAFIDYARPTQRKPEPVDL
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
STVAQDVAARVSSEDGVEIRLRLAPAAIIEADETDMRRVVGNLVENARKYGQSKHDGISR
HHHHHHHHHHCCCCCCCEEEEEECCHHEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCE
ITLETRVSHARVELSVSDEGPGIPEDQLPLVMRPFYRVDTARSKADGTGLGMAIVLRLVG
EEHHHHHCEEEEEEEECCCCCCCCCCCCCHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHH
RYRGTLRLRNRSPEAGLEVTLEFPGTGKARATA
HHCCEEEECCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]