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The map label for this gene is guaA [H]

Identifier: 161524460

GI number: 161524460

Start: 1416140

End: 1417759

Strand: Direct

Name: guaA [H]

Synonym: Bmul_1287

Alternate gene names: 161524460

Gene position: 1416140-1417759 (Clockwise)

Preceding gene: 161524459

Following gene: 161524462

Centisome position: 41.07

GC content: 65.99

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACCCAACTGATCGCGCGCCGCGTGCGTGAAGCGCACGT
CTACTGCGAAATCCATCCGAACGACGTGTCCGACGAATTCGTCCGCGAATTCGCGCCGAAGGCGGTGATCCTGTCGGGCA
GTCACGCGAGCACGTACGAAGATCATCAGCTGCGCGCGCCGCAGGCCGTGTGGGATCTCGGCGTGCCGGTGCTCGGCATC
TGCTACGGGATGCAGACGATGGCCGTGCAGCTCGGCGGCAAGGTCGAGTGGAGCGACCATCGCGAATTCGGCTACGCGGA
AGTGCGTGCGCACGGCCATACGCGCCTGCTCGACGGCATCGAGGACTTCACGACGGCCGAAGGCCACGGCATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTCGCCGAGCTGCCGCCGGGCTTCAAGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGGATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCATCCGGAAGTCACGCATACGGTGAAGGGCCGCCA
GATGCTCGAGCGCTTCGTGCTGCAGATCGCCGGCGCGAAGCCCGACTGGATCATGCGCGACCACATCGAGGAAGCGGTCG
CGAAGATCCGCGAGCAGGTCGGTGACGAGGAAGTGATTCTCGGCCTGTCGGGCGGCGTCGATTCGAGCGTGGCGGCCGCG
CTGATCCATCGCGCAATCGGCGATCAGCTGACCTGCGTGTTCGTCGACCACGGCCTGCTGCGTCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAAGGCCGTCTGCATGCGAAGGTCGTGCACATCGACGCATCGGAGCAGTTCCTCGGCCATCTGG
CCGGCGTGACCGATCCGGAAGCGAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAGGTGTTCCAGGCCGAGGCGAAGAAG
CTGTCGAACGCGAAGTGGCTCGCGCAGGGCACGATCTATCCGGACGTGATCGAGTCGGGCGGCGCGAAGACGAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTCGGCGGCTTGCCCGAGACGCTCGGCCTGAAGCTGCTCGAGCCGCTGCGCGACC
TGTTCAAGGACGAAGTGCGCGAGCTCGGCGTCGCGCTCGGCCTGCCGCCGGAGATGGTCTATCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGGATTCTCGGCGAGGTGAAGCGCGAGTACGCGGACCTGCTGCGCCGCGCGGACGCGATCTTCAT
CGAGGAGTTGCGCAATACGGTCGCGACCGCGCAGGATGCGGCGGCCGGCCTGTGCGGCGAAGCGGACGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTCGGCGTGATGGGCGACGGGCGCACGTAC
GACTACGTGACGGCGCTGCGCGCCGTGCAGACGACGGACTTCATGACGGCGCACTGGGCGCATCTGCCGTACTCGCTGCT
CGGGCGTGTGTCGAACCGGATCATCAACGAAGTGCGCGGGATCAATCGCGCGGTGTACGACATTTCGGGGAAGCCGCCGG
CGACGATTGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
CGAGCCGTCCGCCGCCCGACGTCGCCGTCCATGCTATTGACGCAGCGCAGGTTCGATCGAACGCGCTGCTTTTCTTATTC
TCATCATCCCGTCCGCAGCC

Downstream 100 bases:

>100_bases
AGTCACGCCCGCTCGAGGACTCTCGCAAAACGCTCGTGACGTGCTGATTCAATGAAAGGCACGTCACGGCTGCTATCGGC
AACGATCAGCCGCTATCGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKK
LSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKREYADLLRRADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.4582593250444, Blast_Score=274, Evalue=2e-73,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=64.7388059701492, Blast_Score=694, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992710, Length=578, Percent_Identity=34.7750865051903, Blast_Score=287, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI71992717, Length=578, Percent_Identity=34.7750865051903, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=578, Percent_Identity=34.7750865051903, Blast_Score=287, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=48.1751824817518, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35, Blast_Score=280, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59459; Mature: 59459

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
EDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
EDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPIAGMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
HTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCEEEEHHCCCEEEEEEEECCHHHHHHHHCCCCCHH
AKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHCCCCCCCHHEEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA