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The map label for this gene is lpxD [H]

Identifier: 161524440

GI number: 161524440

Start: 1397171

End: 1398253

Strand: Direct

Name: lpxD [H]

Synonym: Bmul_1267

Alternate gene names: 161524440

Gene position: 1397171-1398253 (Clockwise)

Preceding gene: 161524439

Following gene: 161524441

Centisome position: 40.52

GC content: 68.51

Gene sequence:

>1083_bases
ATGGCATTGACGCTTGAGGAACTCGTAAAGCGGTTCGGCGGCGAGATCGCCGGCGACGCGCAATGCAAGGTCGCCGGCCT
CGCGCCGCTCGACCAGGCCGGCCCTGGGCAGCTCGCGTTCCTCGCGAATCCGAAATACCTGTCGCAGGTCGAGACGACCG
GTGCCGGCGCGGTGCTGATCGCGCCGAAGGATCTGGAAAAGCTGGGCGCGGCCGCGAGCGGCCGCAATTTCATTGTGACG
CCGAATCCGTACGCGTATTTCGCGCGCGTCGCGCAGATGTTCATCGATCTCGCCGCGCCGCCGCGCGCGGCCGGCGTGCA
TCCGAGCGCGACGATCGATCCGGCCGCGCGCGTCGCCGACAGCGCAGTGATCGGCCCGCACGTGACGATCGAGGCGGGCG
CCGTGATCGAAGACGGCGTGCAGCTCGACGCGAACGTGTTCGTCGGCCGCGGCACGACGATCGGCGCAGGCTCGCATCTG
TACCCGAACGTCGCCGTCTATCACGGCTGCAAGATCGGTCCGCGTGCGATCGTGCATGCGGGCGCGGTGATCGGCTCCGA
CGGTTTCGGCTTCGCGCCGGACTTCGTCGGCGACGGCGAGGCGCGCACCGGCACCTGGGTCAAGATTCCGCAGGTCGGCG
GCGTGTCGATCGGCCCGGACGTCGAGATCGGCGCGAACACGACGATCGATCGCGGCGCGATGGCGGACACCGTCATCGAG
GAATGCGTGAAGATCGACAACCAGGTTCAGATCGGCCACAACTGCCGGATCGGCGCGTATACGGTGATCGCAGGCTGCGC
CGGCATCGCGGGCAGCACGACGATCGGGCGCCACTGCATGATCGGCGGCGCGGTCGGGATTGCCGGCCACGTGACGCTCG
GCGACTACGTGATCGTCACGGCGAAATCGGGCGTGTCGAAGTCGCTGCCGAAGGCCGGCATCTATACGAGCGCATTCCCG
GCCGTCGATCACGGCGAATGGAACCGCAGCGCGGCGCTCGTGCGCAACCTCGACAAACTGCGCGATCGCATCAAGGCGCT
CGAAACCGCGCTCGCCGCGCAGCGCGGCGACACGGACGCCTGA

Upstream 100 bases:

>100_bases
CGTGCAGGAAGCCGTGTACGTCAGCCCGCGCATCGACATCACCGACAAGGTGCTCAAGGCACTCGCGTCCGGCTCGACGA
ACTGACGGAGCAGACGACGA

Downstream 100 bases:

>100_bases
CGCGCGATGCGACCGATGAACCGGGCACGGCCAGCGCATCCGGCCCGGTTCGCCAGACAGGGCCGCGTCGCGGCCCGTTT
CAGCTTTTGCTTCACCACCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine; [Acyl-Carrier Protein]. [C]

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MALTLEELVKRFGGEIAGDAQCKVAGLAPLDQAGPGQLAFLANPKYLSQVETTGAGAVLIAPKDLEKLGAAASGRNFIVT
PNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAARVADSAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHL
YPNVAVYHGCKIGPRAIVHAGAVIGSDGFGFAPDFVGDGEARTGTWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIE
ECVKIDNQVQIGHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFP
AVDHGEWNRSAALVRNLDKLRDRIKALETALAAQRGDTDA

Sequences:

>Translated_360_residues
MALTLEELVKRFGGEIAGDAQCKVAGLAPLDQAGPGQLAFLANPKYLSQVETTGAGAVLIAPKDLEKLGAAASGRNFIVT
PNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAARVADSAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHL
YPNVAVYHGCKIGPRAIVHAGAVIGSDGFGFAPDFVGDGEARTGTWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIE
ECVKIDNQVQIGHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFP
AVDHGEWNRSAALVRNLDKLRDRIKALETALAAQRGDTDA
>Mature_359_residues
ALTLEELVKRFGGEIAGDAQCKVAGLAPLDQAGPGQLAFLANPKYLSQVETTGAGAVLIAPKDLEKLGAAASGRNFIVTP
NPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAARVADSAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHLY
PNVAVYHGCKIGPRAIVHAGAVIGSDGFGFAPDFVGDGEARTGTWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIEE
CVKIDNQVQIGHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVTAKSGVSKSLPKAGIYTSAFPA
VDHGEWNRSAALVRNLDKLRDRIKALETALAAQRGDTDA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=353, Percent_Identity=41.0764872521246, Blast_Score=262, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.- [C]

Molecular weight: Translated: 36809; Mature: 36678

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTLEELVKRFGGEIAGDAQCKVAGLAPLDQAGPGQLAFLANPKYLSQVETTGAGAVLI
CCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHCCCCCEEEE
APKDLEKLGAAASGRNFIVTPNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAARVAD
CCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHC
SAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHLYPNVAVYHGCKIGPRAIVHA
CCEECCCEEEECCCEEECCEEEECEEEEECCCEECCCCCCCCCEEEEECCCCCCHHHHEE
GAVIGSDGFGFAPDFVGDGEARTGTWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIE
CEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHH
ECVKIDNQVQIGHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVT
HHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEE
AKSGVSKSLPKAGIYTSAFPAVDHGEWNRSAALVRNLDKLRDRIKALETALAAQRGDTDA
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALTLEELVKRFGGEIAGDAQCKVAGLAPLDQAGPGQLAFLANPKYLSQVETTGAGAVLI
CCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHHCCCCCEEEE
APKDLEKLGAAASGRNFIVTPNPYAYFARVAQMFIDLAAPPRAAGVHPSATIDPAARVAD
CCCCHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHC
SAVIGPHVTIEAGAVIEDGVQLDANVFVGRGTTIGAGSHLYPNVAVYHGCKIGPRAIVHA
CCEECCCEEEECCCEEECCEEEECEEEEECCCEECCCCCCCCCEEEEECCCCCCHHHHEE
GAVIGSDGFGFAPDFVGDGEARTGTWVKIPQVGGVSIGPDVEIGANTTIDRGAMADTVIE
CEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEECCCCCCCCCHHHHHHHH
ECVKIDNQVQIGHNCRIGAYTVIAGCAGIAGSTTIGRHCMIGGAVGIAGHVTLGDYVIVT
HHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCEEEEEEECCEEEEE
AKSGVSKSLPKAGIYTSAFPAVDHGEWNRSAALVRNLDKLRDRIKALETALAAQRGDTDA
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine; (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)Glucosamine + (R)-3-Hydroxytetradecanoyl-[Acyl-Carrier Protein] = UDP-2,3-Bis(3-Hydroxytetradecanoyl)Glucosamine + [Acyl-Carrier Protein]. [C]

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA