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The map label for this gene is dxr [H]

Identifier: 161524436

GI number: 161524436

Start: 1391644

End: 1392840

Strand: Direct

Name: dxr [H]

Synonym: Bmul_1263

Alternate gene names: 161524436

Gene position: 1391644-1392840 (Clockwise)

Preceding gene: 161524435

Following gene: 161524437

Centisome position: 40.36

GC content: 70.01

Gene sequence:

>1197_bases
ATGCAAAAACGTCTGACACTGCTCGGTTCCACGGGCTCGATCGGAGACAGCACGCTCGACGTCGTCGCGCGCCACCCCGA
GCGTTTCTCGGTCTACGCGCTGACCGCGCACCGCAACGGCGACAAGCTCGTCGAACAGTGCCTGCGCTTCGCGCCCGAAG
TCGCGGTGGTCGGCGACGCGGCGACCGCCGCGCACGTCGAGGCGCGGCTGCGCGCGGCGGGCAGCCGGACGACCGTGCTG
TACGGGCCGCAGGCGCTCGTCGACGTGTCGAAGAGCGACGGCTGCGACACGGTCGTCGCGGCGATCGTCGGCGCGGCCGG
TCTCGCGCCGAGCCTCGCGGCCGCGCGCGCCGGCAAGCGGATCCTGCTCGCGAACAAGGAATCGCTGGTGATGTCGGGCG
CGATCTTCATGGACGCGGTGCGCGATCACGGCGCGATCCTGCTGCCGGTCGACAGCGAGCACAACGCGATCTTCCAGTGC
ATGCCGCGTGACGCGGCCGAGCACGGCGGGATCGCGAAGATCATCCTGACCGCGTCGGGCGGCCCGTTCCGCACGCGCGA
GCCGGCGACGCTCGTCGACGTGACGCCGGACGAGGCCTGCAAGCACCCGAACTGGGTGATGGGCCGCAAGATTTCGGTCG
ATTCGGCGACGATGATGAACAAGGGCCTCGAGGTGATCGAGGCGCACTGGATCTTCGGCCTGCCGGGCGACCGGATCGAC
GTGCTGATCCATCCGCAGAGCGTGATCCATTCGCTCGTGTCGTATCGCGACGGTTCGGTGCTCGCGCAACTGGGCAATCC
CGACATGCGCACGCCGATCGCGCACGCGCTCGCGTTTCCGGAGCGCGTCGACGCCGGCGTCGAGCAGCTCGACCTCGCGC
AGATCGCGCAGCTGTCGTTCGAGAAGCCCGACTACGCGCGCTTCCCGTGTCTCGCGCTCGCGCTGAAGGCGCTGGCCGAA
GGCGGTATCGCGAGCGCCGCGTTGAACGCGGCCAACGAAGTCGCGGTCGAAGCGTTTCTCGAGCGCCGGATCGGCTTCAT
GGCGATCGCGGCGACGGTCGAAGCGGTGCTCGACGCGCTGCCGAACCGCGCGCCCGACGGGCTCGACGACGTCCTCGCGG
CCGATGCCGAAGCGCGCCGCCTCGCCGCCGAGATCATTGCGAAAGCGCCTGCGCGACGCGTGGAGCGCACTGTCTGA

Upstream 100 bases:

>100_bases
CCTGCTGCCGGGGCACGGCGGCGTGCTCGACCGCGTCGACGCGCTGCTGCCCGTGCTGCCGCTCGCGATGCTGCTGCTTG
GTTAAACCATTATTTCTGTT

Downstream 100 bases:

>100_bases
ATGAGGTGCTCATGAACGTGCTGGTCGAACTGATCGCATTTGCGGTGGCGATCGGGGTGCTGGTCGTCGTGCATGAGTAC
GGTCATTACCGCGTCGCGCG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDAATAAHVEARLRAAGSRTTVL
YGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKESLVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIILTASGGPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRID
VLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVEQLDLAQIAQLSFEKPDYARFPCLALALKALAE
GGIASAALNAANEVAVEAFLERRIGFMAIAATVEAVLDALPNRAPDGLDDVLAADAEARRLAAEIIAKAPARRVERTV

Sequences:

>Translated_398_residues
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDAATAAHVEARLRAAGSRTTVL
YGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKESLVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIILTASGGPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRID
VLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVEQLDLAQIAQLSFEKPDYARFPCLALALKALAE
GGIASAALNAANEVAVEAFLERRIGFMAIAATVEAVLDALPNRAPDGLDDVLAADAEARRLAAEIIAKAPARRVERTV
>Mature_398_residues
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDAATAAHVEARLRAAGSRTTVL
YGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKESLVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIILTASGGPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRID
VLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVEQLDLAQIAQLSFEKPDYARFPCLALALKALAE
GGIASAALNAANEVAVEAFLERRIGFMAIAATVEAVLDALPNRAPDGLDDVLAADAEARRLAAEIIAKAPARRVERTV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=388, Percent_Identity=57.7319587628866, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42081; Mature: 42081

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCC
ATAAHVEARLRAAGSRTTVLYGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKR
HHHHHHHHHHHHCCCCEEEEECCHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCE
ILLANKESLVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGIAKIILTASG
EEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCEEEEEEEECC
GPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRID
CCCCCCCCCEEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCCHHEEEEEEEECCCCCEE
VLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVEQLDLAQIAQLSF
EEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHCC
EKPDYARFPCLALALKALAEGGIASAALNAANEVAVEAFLERRIGFMAIAATVEAVLDAL
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNRAPDGLDDVLAADAEARRLAAEIIAKAPARRVERTV
CCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVARHPERFSVYALTAHRNGDKLVEQCLRFAPEVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCC
ATAAHVEARLRAAGSRTTVLYGPQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKR
HHHHHHHHHHHHCCCCEEEEECCHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCE
ILLANKESLVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGIAKIILTASG
EEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCEEEEEEEECC
GPFRTREPATLVDVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWIFGLPGDRID
CCCCCCCCCEEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCCHHEEEEEEEECCCCCEE
VLIHPQSVIHSLVSYRDGSVLAQLGNPDMRTPIAHALAFPERVDAGVEQLDLAQIAQLSF
EEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHHCC
EKPDYARFPCLALALKALAEGGIASAALNAANEVAVEAFLERRIGFMAIAATVEAVLDAL
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PNRAPDGLDDVLAADAEARRLAAEIIAKAPARRVERTV
CCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA