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The map label for this gene is nuoM [H]

Identifier: 161524381

GI number: 161524381

Start: 1326293

End: 1327822

Strand: Direct

Name: nuoM [H]

Synonym: Bmul_1208

Alternate gene names: 161524381

Gene position: 1326293-1327822 (Clockwise)

Preceding gene: 161524380

Following gene: 161524382

Centisome position: 38.46

GC content: 66.47

Gene sequence:

>1530_bases
ATGCATGATTTTCCCTTTCTGAGCCTGGCGATCTGGGCTCCGATCCTGTTCGGTGCGTGCCTGCTGCGCGCCGGTTCCGA
CCAACATCTGCAGCGGACGCGCCTCATCGCCCTGATCGGTGCGATCGCGGGGCTCGCCACGGTAGCGCCCATCGTGGCCG
GTTTCGATCCGCACTCGGCGGCGATGCAGTTCGTCGAAAGCCGCAACGGCTTGTCGGCGTTCGGTGCCGGCTGGCGCACG
GGCGTCGACGGCGCGTCGCTGTGGCTCGTCGTGCTGACCGCCTTCACGACGCTCGTGGTCGTCGTCGCATCGTGGCAGGC
CGTCACGGTGCGTGTCGCGCAGTACTACGCGTCGTTCCTGATCCTCTCGGGGCTGATGATCGGCGTCTTCGTCGCACAGG
ACGGGCTGCTGTTCTTCATCTTCTTCGAGGCGACGCTGATCCCGCTGTACCTGCTGATCGGCACGTGGGGCCGCGAGCAT
CGCGTATACGCGGCCGTGAAGTTCTTCTTCATCTCGTTCGCCGGATCGCTGCTGCTGCTGATGGCGATGCTGTACCTGTA
CGCGAAATCGCACACGTTCGACATGGCCGCGTGGCGCACGCTGCAGCTCGGTTTGGCGCCGCAGCTGCTGGTGTTCCTCG
GCTTTTTCGCGGCATTCGCGGTCAAGGTGCCGATGTGGCCGGTCCATACCTGGCTGCGCGACGTCTACACCGACGGCCCG
ACCGGCGCGGCGCTGATGCTCGCGATGCTGAAGCTCGGCGGCTACGGTTTCCTGCGCTTCGCGCTGCCGATCACGCCCGA
CGCGAGCCATTTCTTCGCGCCGGCCGTGATCGCGCTGTCGCTGTTCGCGATCGTCTATGCAAGCCTGCTCGCGCTCGCGC
AAACCGATTTCGGCAAGCTGCTCGCGTATTCGACGGTTGCGCACATGGGCATCGTCACGCTCGGGCTGTTCCTGTTCAAC
CGGATCGGCGTCGAAGGCGCGATCGTGCAGCTCGTGTCGTACGGCTTCGTCGCGGGCGCGATGCTGCTGTGCGCGAGCGT
GCTCGTCGATCGCACGAAGCAGCGCGAGATGACCGCATACGGCGGCGTCGCGAGCGCGATGCCGCGCTTCGCGATGTTTG
CCGTGCTGTTCGCGATGGCGAACGTCGGCCTGCCGGGCACGTCGGGCTTCGTCGGCGAATTCATGGTGATCATGGGCGCG
ATCCGCGTGAACTTCTGGATCGGCGCGGCCGCCGCGCTGACGCTGATCTTCAGCGCGTCGTACACGCTCTGGATGCTCAA
GCGCGTCGTGTGGGGCAGGGCGCCGAGCGCGAGCATCGCGAAGCTCGTCGATCTGAGCGGCCGCGAGATCGCGATGTTCG
CGTCGCTCGCGCTGATCGTGCTCGCGGTCGGCATCGATCCGAAGCCGTTCACCGACGCGATCGATCCGACCGTCGGCCGC
CTGCTCGCGGATGCAAGCCGCTCGAAACTGCCGGCCGGCGACGATACGGCGCCCGCGCAGCCGTCTTACATGGCAGCCGC
TCACGACTGA

Upstream 100 bases:

>100_bases
CAACACTGGCGATTCACGAAATCTACCTGTCGTTTCGGTTTCGTTTCTTTCGTCGCGCCTGTCGTCCGGCGGCGCGCGCC
ATCCTCAAGGCCTTGTTGAC

Downstream 100 bases:

>100_bases
GCGAGCCCCGTTTGCGCCGCGTACGCGTGGCGCATGAATATCGTTGCATGCACATCGATCCCGGTCCGGCGCGACGTGAG
CCGGATCGGCCTGCGCACGT

Product: proton-translocating NADH-quinone oxidoreductase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MHDFPFLSLAIWAPILFGACLLRAGSDQHLQRTRLIALIGAIAGLATVAPIVAGFDPHSAAMQFVESRNGLSAFGAGWRT
GVDGASLWLVVLTAFTTLVVVVASWQAVTVRVAQYYASFLILSGLMIGVFVAQDGLLFFIFFEATLIPLYLLIGTWGREH
RVYAAVKFFFISFAGSLLLLMAMLYLYAKSHTFDMAAWRTLQLGLAPQLLVFLGFFAAFAVKVPMWPVHTWLRDVYTDGP
TGAALMLAMLKLGGYGFLRFALPITPDASHFFAPAVIALSLFAIVYASLLALAQTDFGKLLAYSTVAHMGIVTLGLFLFN
RIGVEGAIVQLVSYGFVAGAMLLCASVLVDRTKQREMTAYGGVASAMPRFAMFAVLFAMANVGLPGTSGFVGEFMVIMGA
IRVNFWIGAAAALTLIFSASYTLWMLKRVVWGRAPSASIAKLVDLSGREIAMFASLALIVLAVGIDPKPFTDAIDPTVGR
LLADASRSKLPAGDDTAPAQPSYMAAAHD

Sequences:

>Translated_509_residues
MHDFPFLSLAIWAPILFGACLLRAGSDQHLQRTRLIALIGAIAGLATVAPIVAGFDPHSAAMQFVESRNGLSAFGAGWRT
GVDGASLWLVVLTAFTTLVVVVASWQAVTVRVAQYYASFLILSGLMIGVFVAQDGLLFFIFFEATLIPLYLLIGTWGREH
RVYAAVKFFFISFAGSLLLLMAMLYLYAKSHTFDMAAWRTLQLGLAPQLLVFLGFFAAFAVKVPMWPVHTWLRDVYTDGP
TGAALMLAMLKLGGYGFLRFALPITPDASHFFAPAVIALSLFAIVYASLLALAQTDFGKLLAYSTVAHMGIVTLGLFLFN
RIGVEGAIVQLVSYGFVAGAMLLCASVLVDRTKQREMTAYGGVASAMPRFAMFAVLFAMANVGLPGTSGFVGEFMVIMGA
IRVNFWIGAAAALTLIFSASYTLWMLKRVVWGRAPSASIAKLVDLSGREIAMFASLALIVLAVGIDPKPFTDAIDPTVGR
LLADASRSKLPAGDDTAPAQPSYMAAAHD
>Mature_509_residues
MHDFPFLSLAIWAPILFGACLLRAGSDQHLQRTRLIALIGAIAGLATVAPIVAGFDPHSAAMQFVESRNGLSAFGAGWRT
GVDGASLWLVVLTAFTTLVVVVASWQAVTVRVAQYYASFLILSGLMIGVFVAQDGLLFFIFFEATLIPLYLLIGTWGREH
RVYAAVKFFFISFAGSLLLLMAMLYLYAKSHTFDMAAWRTLQLGLAPQLLVFLGFFAAFAVKVPMWPVHTWLRDVYTDGP
TGAALMLAMLKLGGYGFLRFALPITPDASHFFAPAVIALSLFAIVYASLLALAQTDFGKLLAYSTVAHMGIVTLGLFLFN
RIGVEGAIVQLVSYGFVAGAMLLCASVLVDRTKQREMTAYGGVASAMPRFAMFAVLFAMANVGLPGTSGFVGEFMVIMGA
IRVNFWIGAAAALTLIFSASYTLWMLKRVVWGRAPSASIAKLVDLSGREIAMFASLALIVLAVGIDPKPFTDAIDPTVGR
LLADASRSKLPAGDDTAPAQPSYMAAAHD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=372, Percent_Identity=28.7634408602151, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1788613, Length=422, Percent_Identity=34.8341232227488, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788827, Length=284, Percent_Identity=28.169014084507, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788829, Length=362, Percent_Identity=30.1104972375691, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788831, Length=420, Percent_Identity=26.4285714285714, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693160, Length=357, Percent_Identity=26.0504201680672, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54620; Mature: 54620

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]