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The map label for this gene is pyrG [H]

Identifier: 161524336

GI number: 161524336

Start: 1280275

End: 1281936

Strand: Direct

Name: pyrG [H]

Synonym: Bmul_1161

Alternate gene names: 161524336

Gene position: 1280275-1281936 (Clockwise)

Preceding gene: 161524335

Following gene: 161524337

Centisome position: 37.13

GC content: 63.3

Gene sequence:

>1662_bases
ATGACCAAATATGTTTTCGTCACCGGCGGCGTAGTTTCTTCCCTCGGCAAGGGCATTGCCGCCGCCTCTCTCGCCGCGAT
CCTCGAATCGCGCGGTCTGAAAGTCACCCTCCTCAAACTCGATCCCTACATCAACGTCGACCCCGGCACGATGAGCCCGT
TTCAGCACGGCGAAGTGTTCGTGACGGAAGACGGCGCAGAGACGGATCTCGACCTCGGCCACTATGAGCGCTTCATCAGC
ACGAAGATGCGCAAGGCCAACAACTTCACGACCGGCCAGATCTACGAATCGGTGATCCGCAAGGAGCGCCGCGGCGACTA
TCTCGGCAAGACCGTGCAGGTCATCCCGCACATCACGAACGAGATCCAGGCGTTCATCGAGCGCGGTGCCGCGTCGGCCA
CCTGCGGCGAGCCGGACGTCGCGATCGTCGAGATCGGCGGCACGGTCGGCGACATCGAGTCGCTGCCGTTCCTCGAGGCC
GCGCGCCAGATGAGCCTGCGCCTCGGCCGCAACAGCGCGTGCTTCGTGCACCTGACGCTCGTGCCGTACATCGCGACGGC
CGGCGAACTGAAGACGAAGCCGACGCAGCACAGCGTGCAGAAGCTGCGCGAGATCGGCATCTCGCCGCACGTGCTGCTGT
GCCGTGCCGACCGCCGCATCCCCGACGACGAATCGAAGAAGATCTCGCTGTTCTCGAACGTGCCGGAAGACGCGGTGATC
TCCGTGTGGGACGTCGACAGCATCTACAAGATTCCGCAGATGCTGCACGACCAGGGCCTCGACCGCATCATCTGCGAGGA
ACTGAAGTTGTCGCCGAAGGACGCCGACCTCAGCATGTGGTCGGAGCTCGTCGAGAAGCTCGAGAATCCGAAGCATGAAG
TGACGATCGGTATGGTCGGCAAGTACGTCGATCTGACCGAGTCGTACAAGTCGCTGATCGAGGCGCTGCGCCACGCGTCG
CTGCATACGTCGACGAAGGTCAACATCGAGTACATCGACTCGGAAGAGATCGAGACGAACGGCGTCGACAGCCTCAAGCA
TCTCGACGCGGTGCTGGTGCCGGGCGGCTTCGGCCGTCGCGGGACCGAAGGCAAGATCGCGGCGATCCGCTATGCGCGCG
AAGCGAAGGTGCCGTATCTCGGCATCTGCCTCGGCATGCAGCTCGCGGTGATCGAATTCGCACGCGACGTCGTCGGCCTG
AAGCAGGCGAACAGCACGGAATTCGATCCGGACACGCCGGAACGCGTGGTCGCGCTGATCACCGAGTGGTACGACCGCGA
AGGCAAGGTCGAGACGCGCACGGAGGATTCCGATCTCGGCGGCACGATGCGCCTCGGCTCGCAGCGCTGCCCGATCAAGC
CCGGCACGCTCGCGGAAGAGATTTACGGCAAGGACGTGAACGAGCGTCACCGTCACCGTTATGAAGTCAATAACCGCTTC
GTGCCCCAGCTCGAAAGCGGCGGCCTTATCATCAGCGCGCGTACCCCGAGCGAGGATCTGCCGGAAATGATGGAACTGCC
GCGTTCGATGCACCCGTGGTTCGTCGGCGTCCAGTTCCACCCGGAATTCACGTCGACGCCGCGTGACGGTCACCCCCTGT
TCAAGTCGTTCGTCGAAGCCGCGCTCGCCAACAAGGAAGCGCGCGCCGGAGTGCAAGCATGA

Upstream 100 bases:

>100_bases
CGGCGCGCGGCACAGCGCGAAGGGGCGCGATCATCGCGTCAATTGCTGAGAGAAGGGCGGGCTTTACGGTATAATCCGTT
TTTCCCGCGAGCATCCAGCG

Downstream 100 bases:

>100_bases
AGCTGTGCGATTTCGAGGTCGGTCTCGACAAGCCTTTCTTCCTGATCGCGGGTACCTGCGTCGTCGAATCGGAGCAAATG
ACGATCGACACCGCCGGCCG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDESKKISLFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
LHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPDTPERVVALITEWYDREGKVETRTEDSDLGGTMRLGSQRCPIKPGTLAEEIYGKDVNERHRHRYEVNNRF
VPQLESGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKEARAGVQA

Sequences:

>Translated_553_residues
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIS
TKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEA
ARQMSLRLGRNSACFVHLTLVPYIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDESKKISLFSNVPEDAVI
SVWDVDSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHAS
LHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGL
KQANSTEFDPDTPERVVALITEWYDREGKVETRTEDSDLGGTMRLGSQRCPIKPGTLAEEIYGKDVNERHRHRYEVNNRF
VPQLESGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKEARAGVQA
>Mature_552_residues
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIST
KMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITNEIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAA
RQMSLRLGRNSACFVHLTLVPYIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDESKKISLFSNVPEDAVIS
VWDVDSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVGKYVDLTESYKSLIEALRHASL
HTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRRGTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLK
QANSTEFDPDTPERVVALITEWYDREGKVETRTEDSDLGGTMRLGSQRCPIKPGTLAEEIYGKDVNERHRHRYEVNNRFV
PQLESGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEAALANKEARAGVQA

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=565, Percent_Identity=45.3097345132743, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=565, Percent_Identity=45.3097345132743, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=565, Percent_Identity=45.3097345132743, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI148491070, Length=562, Percent_Identity=45.729537366548, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1789142, Length=541, Percent_Identity=63.7707948243993, Blast_Score=693, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=40.3940886699507, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=42.4561403508772, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322563, Length=574, Percent_Identity=42.6829268292683, Blast_Score=449, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=45.3571428571429, Blast_Score=480, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21357815, Length=505, Percent_Identity=43.960396039604, Blast_Score=407, Evalue=1e-113,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 61327; Mature: 61195

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDESKKISLFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVG
EEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASLHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVETRTEDSDLGGTMRLGSQRCPIKPGTLAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLESGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEA
CCEECCCCEEEEECCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKEARAGVQA
HHHCCHHHCCCCC
>Mature Secondary Structure 
TKYVFVTGGVVSSLGKGIAAASLAAILESRGLKVTLLKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFISTKMRKANNFTTGQIYESVIRKERRGDYLGKTVQVIPHITN
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHH
EIQAFIERGAASATCGEPDVAIVEIGGTVGDIESLPFLEAARQMSLRLGRNSACFVHLTL
HHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
VPYIATAGELKTKPTQHSVQKLREIGISPHVLLCRADRRIPDDESKKISLFSNVPEDAVI
HHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCEE
SVWDVDSIYKIPQMLHDQGLDRIICEELKLSPKDADLSMWSELVEKLENPKHEVTIGMVG
EEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECC
KYVDLTESYKSLIEALRHASLHTSTKVNIEYIDSEEIETNGVDSLKHLDAVLVPGGFGRR
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHCCEEEECCCCCCC
GTEGKIAAIRYAREAKVPYLGICLGMQLAVIEFARDVVGLKQANSTEFDPDTPERVVALI
CCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
TEWYDREGKVETRTEDSDLGGTMRLGSQRCPIKPGTLAEEIYGKDVNERHRHRYEVNNRF
HHHHCCCCCEECCCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
VPQLESGGLIISARTPSEDLPEMMELPRSMHPWFVGVQFHPEFTSTPRDGHPLFKSFVEA
CCEECCCCEEEEECCCCCCHHHHHHCCHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
ALANKEARAGVQA
HHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA