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The map label for this gene is prlC [H]

Identifier: 161524304

GI number: 161524304

Start: 1240712

End: 1242799

Strand: Reverse

Name: prlC [H]

Synonym: Bmul_1129

Alternate gene names: 161524304

Gene position: 1242799-1240712 (Counterclockwise)

Preceding gene: 161524305

Following gene: 161524302

Centisome position: 36.04

GC content: 67.34

Gene sequence:

>2088_bases
ATGTCCGACAGCGCCCACACCAATCCGCTCCTCGATTTCTCCGGCCTGCCCCGCTTCGGCGAGATTCGCCCCGAACACGT
GACGCCCGCGCTCGACGCATTGCTCGATGCCGCCAATCGCGCCGTCGAAACCGGGAGCGCGCCGGCCACGCCCGCCACCT
GGGCCGACGTCGTCGAAACGGTCGAGCGTGCGACCGAGCCGCTCGGCCGCGCATGGGGCATCGTCGGCCATCTGAACGCG
GTCGCCGATACGCCCGAGCTGCGCGCCGCGTACGGAGAAAACCTGCCGCGCGTGACCGAGTTCTGGTCGAGCGTCGGCCA
GAATCTCGCGCTCTACGACAAGTACAAGGCGATCGCGGCCGGCGCCGAATATGCGACGCTGTCCGCCGAGCGCAAGAAGA
TCCTCGACAACGCACTGCGCGACTTCCGCCTGTCGGGCGCCGAGCTGCCCGAAGACCAGAAGCCGCGTTTCGCGGAACTG
CAGGAGCAGCAGGCCGCACTCGCGAAGGCGTTCTCCGATCACGTGCTCGACGCGACGAACGCGTATGCGTACTTCGCGCA
CGACGAAGCCGAACTGGCCGGCCTGCCGGGCGACGCGATCGAAGCCGCGCGCGAAGCGGCGCAGAAGGACGGCAAGGAAG
GCTGGAAATTCACGCTGCACTTCCCGTCGTATTTCCCGGTGCTGCAGTACGCGGACAACCGCGCGATGCGCGAGACGCTA
TACCGCGCGTATGCGACGCGCGCCTCGGAGCTCGGCCCGCAGTACGGCGGCGGCAAGGCCGAATGGGACAACACCGCGAT
CGTCGCCGACGAACTGAAGCTGCGCCGCGAAGAAGCGCAGATGCTCGGCTACCGCAACTTCGCCGAAGTGTCGCTCGCGC
CGAAGATGGCCGAGTCGCCGCAGCAGGTGATCGCGTTCCTCGAGGATCTCGCGACGCGCGCGCGTCCGCACGCGGAAAAG
GACTGGGACGAGCTGCGCGCGTTCGCCTCGAAAGAACTCGGCCTCGGCGAGCTCGCGCCGTGGGACATCGCGTACGCGGC
CGAGAAGCTGCGCCAGCAGCGCTATGCGTTCTCGGAAAACGAGGTCAAGCAGTACTTCCCGGAACCGGCCGTGCTGAAGG
GTCTGTTCACCGTGACCGAGACGCTGTTCGGCGTACGGATCAAGCCGGACGATGCGCCGGTCTGGCACCCGGACGTGCGC
TTTTTCCGCGTCGAAAACCGCGACGGCTCGCTCGTCGCGCAGTTCTATCTCGATCTGTACGCACGCGAAGGCAAGCGCGG
CGGCGCGTGGATGGACGACGCGCGTTCGCGCGCGAAGCGCGGCGACGGCGTGCAGACGCCCGTCGCGTATCTGACCTGCA
ACTTCTCCGCACCGGTCGGCGGCAAGCCCGCCTGCTTCACGCACGACGAAGTGATCACGCTGTTCCACGAGTTCGGCCAC
GGGCTGCATCACATGCTCACGCGCGTCGACGAGCTCGGCGTGTCCGGCATCAACGGCGTCGAATGGGATGCGGTCGAGCT
GCCGTCGCAGTTCATGGAGAACTTCTGCTGGGAATGGGACGTGCTGTCGTCGATGTCGTCGCACGTCGATACGGGCGCGT
CGCTGCCGCGCGCGCTGTTCGACAAGATGATCGCCGCGAAGAACTTCCAGAGCGGCCTCGGCACGCTGCGGCAGATCGTG
TTCTCGATGTTCGACATGCTGCTGCACGTCGATCTCGATCCGGCCGGCGCGCTCGCCGTGAACGACTTTGCGCGCGACAT
CAACGAGCGCTATCACGTGATCCCGCAGGCGCCGTTCTCGCGCTGGCCGAACACGTTCAGCCACATCTTCGCGGGCGGCT
ACGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTGCTGTCCGCCGACGCCTATGCGGCGTTCGAGGAAGCGGCCGCC
GCGAACGGCAGCGTGCTCGATGCGGCAACCGGCACGCGCTATCGCCGCGAGATCCTCGAGGTCGGCGGCAGCCGCCCGGC
GATGGATTCGTTCAAGGCGTTCCGCGGCCGCGAGCCGAAGATCGACGCGCTGCTGCGTCATAACGGGATGGCCGCGCCCG
CACACTGA

Upstream 100 bases:

>100_bases
GATTGGAAAGCGCGCGACGCGCCCCAATAATGTCGGTATCGGCGCGCCTCGCGCCTCACCGTTTTCATCCCGGTTCATCC
GGCAACAGACAGGGAGTCTT

Downstream 100 bases:

>100_bases
CGGGCTGCGCCGCGTCGCCGCCGCACAGGCACCGCTTCGGCGGTGCCTTTTTCATTGCGCGCTCATTGCGCGCGCGAGTC
GTCGTCGAACAGCGAGAACT

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MSDSAHTNPLLDFSGLPRFGEIRPEHVTPALDALLDAANRAVETGSAPATPATWADVVETVERATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYDKYKAIAAGAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALAKAFSDHVLDATNAYAYFAHDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRAMRETL
YRAYATRASELGPQYGGGKAEWDNTAIVADELKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHAEK
DWDELRAFASKELGLGELAPWDIAYAAEKLRQQRYAFSENEVKQYFPEPAVLKGLFTVTETLFGVRIKPDDAPVWHPDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRALFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDLDPAGALAVNDFARDINERYHVIPQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ANGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPKIDALLRHNGMAAPAH

Sequences:

>Translated_695_residues
MSDSAHTNPLLDFSGLPRFGEIRPEHVTPALDALLDAANRAVETGSAPATPATWADVVETVERATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYDKYKAIAAGAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALAKAFSDHVLDATNAYAYFAHDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRAMRETL
YRAYATRASELGPQYGGGKAEWDNTAIVADELKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHAEK
DWDELRAFASKELGLGELAPWDIAYAAEKLRQQRYAFSENEVKQYFPEPAVLKGLFTVTETLFGVRIKPDDAPVWHPDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRALFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDLDPAGALAVNDFARDINERYHVIPQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ANGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPKIDALLRHNGMAAPAH
>Mature_694_residues
SDSAHTNPLLDFSGLPRFGEIRPEHVTPALDALLDAANRAVETGSAPATPATWADVVETVERATEPLGRAWGIVGHLNAV
ADTPELRAAYGENLPRVTEFWSSVGQNLALYDKYKAIAAGAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQ
EQQAALAKAFSDHVLDATNAYAYFAHDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRAMRETLY
RAYATRASELGPQYGGGKAEWDNTAIVADELKLRREEAQMLGYRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHAEKD
WDELRAFASKELGLGELAPWDIAYAAEKLRQQRYAFSENEVKQYFPEPAVLKGLFTVTETLFGVRIKPDDAPVWHPDVRF
FRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGDGVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGHG
LHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRALFDKMIAAKNFQSGLGTLRQIVF
SMFDMLLHVDLDPAGALAVNDFARDINERYHVIPQAPFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAA
NGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPKIDALLRHNGMAAPAH

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=622, Percent_Identity=32.3151125401929, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI14149738, Length=625, Percent_Identity=32.32, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI156105687, Length=659, Percent_Identity=25.0379362670713, Blast_Score=173, Evalue=6e-43,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=50.7288629737609, Blast_Score=693, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=30.1013024602026, Blast_Score=277, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI71999758, Length=526, Percent_Identity=25.6653992395437, Blast_Score=138, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32565901, Length=631, Percent_Identity=21.8700475435816, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319793, Length=689, Percent_Identity=29.3178519593614, Blast_Score=280, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6322715, Length=702, Percent_Identity=23.7891737891738, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI21356111, Length=693, Percent_Identity=26.1183261183261, Blast_Score=236, Evalue=5e-62,
Organism=Drosophila melanogaster, GI20129717, Length=556, Percent_Identity=25.3597122302158, Blast_Score=155, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77007; Mature: 76876

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSAHTNPLLDFSGLPRFGEIRPEHVTPALDALLDAANRAVETGSAPATPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VERATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYDKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHC
GAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALAKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFAHDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRAMRETL
CEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGGGKAEWDNTAIVADELKLRREEAQMLGYRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHAEKDWDELRAFASKELGLGELAPWDIAYAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVTETLFGVRIKPDDAPVWHPDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRALF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDLDPAGALAVNDFARDINERYHVIPQAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCCHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAANGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
VGGSRPAMDSFKAFRGREPKIDALLRHNGMAAPAH
CCCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SDSAHTNPLLDFSGLPRFGEIRPEHVTPALDALLDAANRAVETGSAPATPATWADVVET
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VERATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYDKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHC
GAEYATLSAERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALAKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFAHDEAELAGLPGDAIEAAREAAQKDGKEGWKFTLHFPSYFPVLQYADNRAMRETL
CEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGGGKAEWDNTAIVADELKLRREEAQMLGYRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHAEKDWDELRAFASKELGLGELAPWDIAYAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAVLKGLFTVTETLFGVRIKPDDAPVWHPDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGDGVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGASLPRALF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDLDPAGALAVNDFARDINERYHVIPQAPFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEECCCCCHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAANGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
VGGSRPAMDSFKAFRGREPKIDALLRHNGMAAPAH
CCCCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]