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The map label for this gene is uvrB [H]

Identifier: 161524243

GI number: 161524243

Start: 1166535

End: 1168733

Strand: Direct

Name: uvrB [H]

Synonym: Bmul_1067

Alternate gene names: 161524243

Gene position: 1166535-1168733 (Clockwise)

Preceding gene: 161524241

Following gene: 161524244

Centisome position: 33.83

GC content: 65.53

Gene sequence:

>2199_bases
GTGCCCGATCGCGATGTCGGCCGGCCGCGGCGTGTCGGGAGGCGGCAGCAGATCGCGCCGTCGCGAAGCGCTAGAATAGT
TTTTTTGCCTCCGCACCGGCTGCACTCCATGTCAGAACACCATGCCGAAATCGGCGACACGCTCGACGAATCCAAATTCG
TGACGTTCGAAGGGTCGCCGTTCCAGCTCTATCAGCCGTATCCGCCCGCGGGCGACCAGCCGACCGCCATCGACACGCTC
GTCGAAGGCGTGCAGGACGGTCTCGCATTCCAGACGCTGCTCGGCGTGACGGGCTCGGGCAAGACCTTCACGATGGCGAA
TACGATCGCGCGGCTCGGCCGCCCGGCGATCGTGTTCGCGCCGAACAAGACGCTCGCCGCGCAGCTCTACGCGGAGTTCC
GGGAGTTCTTCCCGCGCAATGCGGTCGAGTATTTCGTGTCGTACTACGATTACTACCAGCCGGAAGCGTACGTGCCGCAG
CGCGACCTGTTCATCGAGAAGGACTCGTCGATCAACGAGCACATCGAGCAGATGCGGCTGTCAGCGACCAAGAGCCTGAT
GGAGCGCCGCGACGTCGTGATCGTCGCGACGGTGTCGGCCATCTACGGTATCGGCAATCCGTCCGAATACCACCAGATGA
TCCTGACGCTGCGCACCGGCGACAAGCTCGGCCAGCGCGACGTGATCGCGCGGCTGATCGCGATGCAGTACACGCGCAAC
GAGCAGGACTTCCAGCGCGGCACGTTCCGCGTGCGCGGCGACACGATCGACATCTTCCCGGCCGAACACGCGGAGATGGC
CGTGCGCGTCGAGCTGTTCGACGACGAGGTCGAGACGCTGCAGCTGTTCGACCCGCTGACGGGGCGCGTGCGCCAGAAGA
TCCCGCGCTTCACCGTGTATCCGTCGTCGCACTACGTGACGCCGCGCGACACCGTGATGCGCGCGGTCGAGACGATCAAG
GAGGAGCTGCGCGAGCGGCTCGAGTTCTTCCACCGCGAAGGCAAGCTCGTCGAAGCGCAGCGTCTCGAGCAGCGTACGCG
CTTCGACCTCGAGATGCTGCAGGAGCTCGGCTTCTGCAAGGGCATCGAGAACTACTCGCGGCACTTTTCGGGCGCGGCGC
CCGGCGAGCCGCCGCCGACGCTCGTCGACTACCTGCCGCCCGACGCGCTGATGCTGCTCGACGAATCGCACGTGCTGATC
GGCCAGCTGAACGGCATGTACAACGGCGACCGCGCGCGCAAGGAAAACCTCGTGAATTACGGGTTCCGGCTGCCGTCGGC
GCTCGACAACCGGCCGCTGAAGTTCCACGAGTTCGAGCGCAAGATGCGCCAGGTCGTGTTCGTGTCGGCGACGCCGGCCG
ACTACGAGCAGCGCGTGACGGGGCAGATCGCGGAGCAGGTCGTGCGGCCGACCGGGCTCGTCGATCCGGAAATCGAGGTG
CGGCCCGCGAGTTCGCAGGTCGACGACGTGCTGACCGAAATCAACGCACGCGTGAAGGCCGGCGAACGTGTGCTGATCAC
CGTGCTGACGAAGCGGATGGCCGAGCAGCTGACCGAGTTCCTTGCCGATCACGGCATCAAGGTGCGCTATCTGCACAGCG
ACATCGACACGGTCGAGCGCGTGGAAATCATCCGCGACCTGCGGCTCGGCACGTTCGACGTGCTGGTCGGGATCAACCTG
CTGCGCGAAGGGCTCGACATCCCGGAGGTGTCGCTCGTCGCGATCCTCGACGCGGACAAGGAGGGCTTCCTGCGCGCCGA
GCGTTCGCTGATCCAGACGATCGGCCGTGCGGCGCGCAACGTGAACGGCAAGGCGATCCTGTACGCGGACACGATGACCG
AGTCGATGAAGCGCGCGATCGGCGAGACCGAGCGGCGCCGCGCGAAGCAGATCGCGTACAACGAGAAGATGGGCATCACG
CCGCGCGGCGTGGTCAAGCGCATCAAGGACATCATCGACGGCGTCTACAACGCCGACGACGCGCGCGCCGAACTGAAGGA
AGCGCAGCAGCGCGCGAAATTCGAGGACATGTCGGAGAAGCAGCTCGCGAAGGAAATCAAGCGTCTCGAGAAGCAGATGG
CCGACTACGCGAAGAACCTCGAATTCGAGAAGGCGGCCGCGACGCGCGATCAGCTCGCGCTGCTGCGCGAGCGCGTGTTC
GGCGCGAATGTCGGCGATCACGTGAGCGGCGGCCGGTAA

Upstream 100 bases:

>100_bases
CTTTCAACCGGCAAGGCGGACGCTGCAGCGCCCGCATGGGCAGGCACGACGCCGGGAAGCGCAGCAGCCTGACATTGTAG
CGAATTCGCGCCGGAGCGAC

Downstream 100 bases:

>100_bases
ATCTTTCCCAACATCGCTGAAACCTGCCGGTAACGGCCGTGTAAGCCTTGTCGCATCAGGGGTTTGCGGCCGTTCCGGTT
TGTTCGGAAACCGGTTCGGT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MPDRDVGRPRRVGRRQQIAPSRSARIVFLPPHRLHSMSEHHAEIGDTLDESKFVTFEGSPFQLYQPYPPAGDQPTAIDTL
VEGVQDGLAFQTLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQ
RDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKLGQRDVIARLIAMQYTRN
EQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIK
EELRERLEFFHREGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLI
GQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFHEFERKMRQVVFVSATPADYEQRVTGQIAEQVVRPTGLVDPEIEV
RPASSQVDDVLTEINARVKAGERVLITVLTKRMAEQLTEFLADHGIKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINL
LREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADTMTESMKRAIGETERRRAKQIAYNEKMGIT
PRGVVKRIKDIIDGVYNADDARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAAATRDQLALLRERVF
GANVGDHVSGGR

Sequences:

>Translated_732_residues
MPDRDVGRPRRVGRRQQIAPSRSARIVFLPPHRLHSMSEHHAEIGDTLDESKFVTFEGSPFQLYQPYPPAGDQPTAIDTL
VEGVQDGLAFQTLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQ
RDLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKLGQRDVIARLIAMQYTRN
EQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIK
EELRERLEFFHREGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLI
GQLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFHEFERKMRQVVFVSATPADYEQRVTGQIAEQVVRPTGLVDPEIEV
RPASSQVDDVLTEINARVKAGERVLITVLTKRMAEQLTEFLADHGIKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINL
LREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADTMTESMKRAIGETERRRAKQIAYNEKMGIT
PRGVVKRIKDIIDGVYNADDARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAAATRDQLALLRERVF
GANVGDHVSGGR
>Mature_731_residues
PDRDVGRPRRVGRRQQIAPSRSARIVFLPPHRLHSMSEHHAEIGDTLDESKFVTFEGSPFQLYQPYPPAGDQPTAIDTLV
EGVQDGLAFQTLLGVTGSGKTFTMANTIARLGRPAIVFAPNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQR
DLFIEKDSSINEHIEQMRLSATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKLGQRDVIARLIAMQYTRNE
QDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVYPSSHYVTPRDTVMRAVETIKE
ELRERLEFFHREGKLVEAQRLEQRTRFDLEMLQELGFCKGIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIG
QLNGMYNGDRARKENLVNYGFRLPSALDNRPLKFHEFERKMRQVVFVSATPADYEQRVTGQIAEQVVRPTGLVDPEIEVR
PASSQVDDVLTEINARVKAGERVLITVLTKRMAEQLTEFLADHGIKVRYLHSDIDTVERVEIIRDLRLGTFDVLVGINLL
REGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARNVNGKAILYADTMTESMKRAIGETERRRAKQIAYNEKMGITP
RGVVKRIKDIIDGVYNADDARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAAATRDQLALLRERVFG
ANVGDHVSGGR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=65.8718330849478, Blast_Score=868, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.1270358306189, Blast_Score=73, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 83349; Mature: 83218

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRDVGRPRRVGRRQQIAPSRSARIVFLPPHRLHSMSEHHAEIGDTLDESKFVTFEGSP
CCCCCCCCCHHHCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
FQLYQPYPPAGDQPTAIDTLVEGVQDGLAFQTLLGVTGSGKTFTMANTIARLGRPAIVFA
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEEEC
PNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHH
SATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKLGQRDVIARLIAMQYTRN
HHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCC
EQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVY
HHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEC
PSSHYVTPRDTVMRAVETIKEELRERLEFFHREGKLVEAQRLEQRTRFDLEMLQELGFCK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVNY
CHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHH
GFRLPSALDNRPLKFHEFERKMRQVVFVSATPADYEQRVTGQIAEQVVRPTGLVDPEIEV
CCCCCHHHCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
RPASSQVDDVLTEINARVKAGERVLITVLTKRMAEQLTEFLADHGIKVRYLHSDIDTVER
ECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
VEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARN
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
VNGKAILYADTMTESMKRAIGETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADD
CCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCH
ARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAAATRDQLALLRERVF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GANVGDHVSGGR
CCCCCCCCCCCC
>Mature Secondary Structure 
PDRDVGRPRRVGRRQQIAPSRSARIVFLPPHRLHSMSEHHAEIGDTLDESKFVTFEGSP
CCCCCCCCHHHCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
FQLYQPYPPAGDQPTAIDTLVEGVQDGLAFQTLLGVTGSGKTFTMANTIARLGRPAIVFA
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCEEEEC
PNKTLAAQLYAEFREFFPRNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSSINEHIEQMRL
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHH
SATKSLMERRDVVIVATVSAIYGIGNPSEYHQMILTLRTGDKLGQRDVIARLIAMQYTRN
HHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHCCC
EQDFQRGTFRVRGDTIDIFPAEHAEMAVRVELFDDEVETLQLFDPLTGRVRQKIPRFTVY
HHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEC
PSSHYVTPRDTVMRAVETIKEELRERLEFFHREGKLVEAQRLEQRTRFDLEMLQELGFCK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIENYSRHFSGAAPGEPPPTLVDYLPPDALMLLDESHVLIGQLNGMYNGDRARKENLVNY
CHHHHHHHCCCCCCCCCCCCHHHCCCCCEEEEECCCCEEEEECCCCCCCCHHHHHHHHHH
GFRLPSALDNRPLKFHEFERKMRQVVFVSATPADYEQRVTGQIAEQVVRPTGLVDPEIEV
CCCCCHHHCCCCCHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCEE
RPASSQVDDVLTEINARVKAGERVLITVLTKRMAEQLTEFLADHGIKVRYLHSDIDTVER
ECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHH
VEIIRDLRLGTFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGRAARN
HHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHC
VNGKAILYADTMTESMKRAIGETERRRAKQIAYNEKMGITPRGVVKRIKDIIDGVYNADD
CCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCH
ARAELKEAQQRAKFEDMSEKQLAKEIKRLEKQMADYAKNLEFEKAAATRDQLALLRERVF
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
GANVGDHVSGGR
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA