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The map label for this gene is yngJ [H]

Identifier: 161524222

GI number: 161524222

Start: 1142530

End: 1143663

Strand: Direct

Name: yngJ [H]

Synonym: Bmul_1046

Alternate gene names: 161524222

Gene position: 1142530-1143663 (Clockwise)

Preceding gene: 161524221

Following gene: 161524223

Centisome position: 33.13

GC content: 68.25

Gene sequence:

>1134_bases
ATGGATTTCACCTTTACCGATGAGCAGCAGCAGTTCGCCGAGGCGCTTCGCCGTTATCTCGGCGAGCAGTACGGCTTCGA
TGCGCGTCAGGCGATCGTGCACAGCGACGCGGGCGTGTCGGAAACGCAATGGCAGGCGTTCGCGGAACTCGGGCTGACCG
CGTTGCCGGTGCCCGAGGCGCAAGGCGGTTTCGGCGGCGGCGCAGTCGACATGCTGGTCGTCATGCAGGAGCTCGGGCGT
GCGCTCGTCGTCGAGCCTTACTGGGCGACCGCGGTCGGCGTCGAAGCGCTGCGTATCGCGGGCGCCGGCACCGGCGACGA
CGCGGCGCTGCTGGAAGCGGTCGCGCAGGGCCGCAAGCGTCTTGCCGTGGCATTTCACGAGCCGCATGCACGCTACGACC
TGTTCGAGCTCGCGACGCGCGCGCACGAGCAGGGCGGCACGGTGCGGCTGTCGGGCACGAAATCGGTCGTGCAGCACGGT
GCGCAGGCGCATGCGTGGATCGTTCCCGCGCGTGTCGACGACGGCGCGATTGCGCTGTTCGTCGTCGACCGCGAGACGGC
CGGCGCGAAAGTCGTCGACTATCGGACCATCGACGGCCAGCGTGCGGCGACGATCGTATTCGACGATACGCCTGCGCGGC
GGCTGACGGGCGGCGCGCGCGATGCGGCCGCACTCGAGCAGATCGCCGATTACGCGACGTTCCTGCTGTGCGCGGAAGCG
GTCGGCGCGCTCGACGAGCTCAACCGTGCGACGGTCGACTACACGAAGACGCGCGAACAGTTCGGCATGCCGATCGCGCG
CTTCCAGGTGCTGCAGCACCGGATGGTCGACATGCTGATTCACGCGGAGCAGGCGCGTTCGCTCACGTATCTCGCGGCCG
TGCGTTATGCGAGCAGCGATGTCGATGCGCGACGCAAGGCCATCTCGGCCGCGAAGGCGCGTGTCGGTGCGGCCGCGCGC
TTCGTCGGCCAGCAGGCCGTTCAGCTGCATGGCGGAATGGGCGTGACGAACGAAGTGGCGGCCGCGCATCTGTTCAAGCG
GCTGTCGATCATCGAAACGACGCTCGGCGATACCGATCATCATCTTGCGCGCATCGCGGCGCTGCCCGACTTCGCGCAGA
CCGACGCGGCATGA

Upstream 100 bases:

>100_bases
GAAGACGTCGATCTACGGCGGCTCGAACGAAATTCAGAAAAACATCATCGCGCAGATGATTCTCGGCCTCTGAGCCGAGC
TCACGCGATCGGAGACAACG

Downstream 100 bases:

>100_bases
CGTCGGCGCGCCGGGCGCGCCAATCACCAGGAGACCCGCAGTGGGCATCAGCTACGAAGATCTCGAAGTCGGCAGTACCG
TCGAAATCGGCCGCTACACG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDFTFTDEQQQFAEALRRYLGEQYGFDARQAIVHSDAGVSETQWQAFAELGLTALPVPEAQGGFGGGAVDMLVVMQELGR
ALVVEPYWATAVGVEALRIAGAGTGDDAALLEAVAQGRKRLAVAFHEPHARYDLFELATRAHEQGGTVRLSGTKSVVQHG
AQAHAWIVPARVDDGAIALFVVDRETAGAKVVDYRTIDGQRAATIVFDDTPARRLTGGARDAAALEQIADYATFLLCAEA
VGALDELNRATVDYTKTREQFGMPIARFQVLQHRMVDMLIHAEQARSLTYLAAVRYASSDVDARRKAISAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARIAALPDFAQTDAA

Sequences:

>Translated_377_residues
MDFTFTDEQQQFAEALRRYLGEQYGFDARQAIVHSDAGVSETQWQAFAELGLTALPVPEAQGGFGGGAVDMLVVMQELGR
ALVVEPYWATAVGVEALRIAGAGTGDDAALLEAVAQGRKRLAVAFHEPHARYDLFELATRAHEQGGTVRLSGTKSVVQHG
AQAHAWIVPARVDDGAIALFVVDRETAGAKVVDYRTIDGQRAATIVFDDTPARRLTGGARDAAALEQIADYATFLLCAEA
VGALDELNRATVDYTKTREQFGMPIARFQVLQHRMVDMLIHAEQARSLTYLAAVRYASSDVDARRKAISAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARIAALPDFAQTDAA
>Mature_377_residues
MDFTFTDEQQQFAEALRRYLGEQYGFDARQAIVHSDAGVSETQWQAFAELGLTALPVPEAQGGFGGGAVDMLVVMQELGR
ALVVEPYWATAVGVEALRIAGAGTGDDAALLEAVAQGRKRLAVAFHEPHARYDLFELATRAHEQGGTVRLSGTKSVVQHG
AQAHAWIVPARVDDGAIALFVVDRETAGAKVVDYRTIDGQRAATIVFDDTPARRLTGGARDAAALEQIADYATFLLCAEA
VGALDELNRATVDYTKTREQFGMPIARFQVLQHRMVDMLIHAEQARSLTYLAAVRYASSDVDARRKAISAAKARVGAAAR
FVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDHHLARIAALPDFAQTDAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=23.0352303523035, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=24.4117647058824, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4557233, Length=323, Percent_Identity=27.5541795665635, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI187960098, Length=399, Percent_Identity=25.31328320802, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4557231, Length=399, Percent_Identity=25.31328320802, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=25.1295336787565, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501857, Length=368, Percent_Identity=23.9130434782609, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=24.3835616438356, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4503943, Length=264, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786223, Length=374, Percent_Identity=24.5989304812834, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17538396, Length=371, Percent_Identity=23.4501347708895, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=352, Percent_Identity=28.125, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=26.246719160105, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=336, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=339, Percent_Identity=26.5486725663717, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17569725, Length=396, Percent_Identity=25.5050505050505, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=396, Percent_Identity=25.2525252525253, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356377, Length=337, Percent_Identity=27.299703264095, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646207, Length=331, Percent_Identity=26.8882175226586, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355753, Length=332, Percent_Identity=26.2048192771084, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24666513, Length=340, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=26.0981912144703, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40525; Mature: 40525

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFTFTDEQQQFAEALRRYLGEQYGFDARQAIVHSDAGVSETQWQAFAELGLTALPVPEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCCC
QGGFGGGAVDMLVVMQELGRALVVEPYWATAVGVEALRIAGAGTGDDAALLEAVAQGRKR
CCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCHHE
LAVAFHEPHARYDLFELATRAHEQGGTVRLSGTKSVVQHGAQAHAWIVPARVDDGAIALF
EEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCEEEEEEEECCCEEEEE
VVDRETAGAKVVDYRTIDGQRAATIVFDDTPARRLTGGARDAAALEQIADYATFLLCAEA
EEECCCCCCEEEEEEECCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGALDELNRATVDYTKTREQFGMPIARFQVLQHRMVDMLIHAEQARSLTYLAAVRYASSD
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDARRKAISAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
HLARIAALPDFAQTDAA
HHHHHHHCCCHHHCCCC
>Mature Secondary Structure
MDFTFTDEQQQFAEALRRYLGEQYGFDARQAIVHSDAGVSETQWQAFAELGLTALPVPEA
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCCEECCCCCC
QGGFGGGAVDMLVVMQELGRALVVEPYWATAVGVEALRIAGAGTGDDAALLEAVAQGRKR
CCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCHHE
LAVAFHEPHARYDLFELATRAHEQGGTVRLSGTKSVVQHGAQAHAWIVPARVDDGAIALF
EEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCCCCEEEEEEEECCCEEEEE
VVDRETAGAKVVDYRTIDGQRAATIVFDDTPARRLTGGARDAAALEQIADYATFLLCAEA
EEECCCCCCEEEEEEECCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGALDELNRATVDYTKTREQFGMPIARFQVLQHRMVDMLIHAEQARSLTYLAAVRYASSD
HHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDARRKAISAAKARVGAAARFVGQQAVQLHGGMGVTNEVAAAHLFKRLSIIETTLGDTDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
HLARIAALPDFAQTDAA
HHHHHHHCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]