Click here to switch to the map view.

The map label for this gene is hisM [H]

Identifier: 161524063

GI number: 161524063

Start: 969686

End: 970399

Strand: Reverse

Name: hisM [H]

Synonym: Bmul_0884

Alternate gene names: 161524063

Gene position: 970399-969686 (Counterclockwise)

Preceding gene: 161524064

Following gene: 161524062

Centisome position: 28.14

GC content: 64.15

Gene sequence:

>714_bases
ATGATCGAACTCATCCAAGAATACTGGCGCAACTATCTGTACACCGACGGCTACCGGATCACGGGCGTCGCGATCACGCT
GTGGCTGCTCGTCGTGTCGATCGGGCTCGGGTTCTGCCTGTCGGTGCCGCTCGCGGTCGCGCGCGTGTCGAAGCGCAAAT
GGCTGTCGCGCGCGGTATGGCTCTATACCTACGTGTTCCGCGGCACGCCGCTCTACGTGCAGCTGCTGCTCTGCTATACG
GGCCTGTACAGCCTGCAGGTCGTGCGCGGCACGCCGATGCTCGACGCGTTCTTCCGCGAAGGCATGAACTGCACGCTGCT
CGCGTTCACGCTGAACACCTGCGCGTATACCACCGAGATCTTCGCGGGTGCGATCAAGGCGACGTCGTACGGCGAGATCG
AAGCCGCGCGCGCGTACGGGATGTCGACGTTCACGATGTACCGCCGCGTGATCCTGCCGTCCGCGCTGCGCCGCTCGCTG
CCGCTCTACAGCAATGAAGTGATCCTGATGCTGCACGCGACGACCGTCGCGTTCACCGCGACCGTGCCCGACATCCTGAA
GATCGCGCGCGACGTCAACTCGGCGACCTACATGTCGTTCCATGCATTCGGGATCGCCGCCCTGCTCTATCTCGTGATCT
CCTTCACGCTCGTCTGGCTGTTCCGCCGCGCCGAGCGCCGCTGGCTCGCGTATCTGCGCCCGCAAGGCAAGTAA

Upstream 100 bases:

>100_bases
TGATCGCCGGCGCGATCTACCTCGCCATCACGACGATCTCGAACTTCGTGCTGATGTGGCTTGAAAAGCGCTACTCGACC
GGCGTCCGCAAGGCAGACCT

Downstream 100 bases:

>100_bases
GTTTCCGCAGGACTATTCATGAATTCCCAGACCCAGAAGCTTTTCGTCGACGATCTTCACAAGCGGTACGGCAGCAACGA
GGTGCTCAAGGGCGTGTCGC

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSRAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQVVRGTPMLDAFFREGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRSL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRRAERRWLAYLRPQGK

Sequences:

>Translated_237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSRAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQVVRGTPMLDAFFREGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRSL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRRAERRWLAYLRPQGK
>Mature_237_residues
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSRAVWLYTYVFRGTPLYVQLLLCYT
GLYSLQVVRGTPMLDAFFREGMNCTLLAFTLNTCAYTTEIFAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRSL
PLYSNEVILMLHATTVAFTATVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRRAERRWLAYLRPQGK

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=66.5254237288136, Blast_Score=337, Evalue=3e-94,
Organism=Escherichia coli, GI1787086, Length=213, Percent_Identity=34.2723004694836, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1788226, Length=226, Percent_Identity=30.9734513274336, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1787030, Length=209, Percent_Identity=29.1866028708134, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786873, Length=224, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1788646, Length=214, Percent_Identity=26.6355140186916, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787087, Length=124, Percent_Identity=27.4193548387097, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994930, Length=184, Percent_Identity=28.2608695652174, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27064; Mature: 27064

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSRAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQVVRGTPMLDAFFREGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRSLPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIELIQEYWRNYLYTDGYRITGVAITLWLLVVSIGLGFCLSVPLAVARVSKRKWLSRAVW
CHHHHHHHHHHCEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYVFRGTPLYVQLLLCYTGLYSLQVVRGTPMLDAFFREGMNCTLLAFTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIKATSYGEIEAARAYGMSTFTMYRRVILPSALRRSLPLYSNEVILMLHATTVAFTA
HHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNSATYMSFHAFGIAALLYLVISFTLVWLFRRAERRWLAYLRPQGK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]