| Definition | Burkholderia multivorans ATCC 17616 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010084 |
| Length | 3,448,466 |
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The map label for this gene is fabG [H]
Identifier: 161524052
GI number: 161524052
Start: 957925
End: 958683
Strand: Reverse
Name: fabG [H]
Synonym: Bmul_0873
Alternate gene names: 161524052
Gene position: 958683-957925 (Counterclockwise)
Preceding gene: 161524053
Following gene: 161524051
Centisome position: 27.8
GC content: 67.85
Gene sequence:
>759_bases ATGCGGTTGAGCGGCAAGACGGCGATCGTCACGGGCGGCGGCTCGGGCTTCGGCGAAGGCATCGCGAAGACGTATGCGCG CGAAGGCGCGAACGTCGTCGTCAACGATCTGAACGGCGCGGCGGCCGAGCGTGTCGCGAGCGAGATCGCGCTCGCGGGCG GCAAGGCGATCGCGGTCGCGGGCGACGTGTCCCGAGGCGACGACTGGCGCGCCTTGCAGCAGGCGGCGCTCGACGATTTC CACGCGGTGCAGATCGTCGTGAATAACGCGGGCACCACGCATCGCAACAAGCCCGTGCTCGACGTGACCGAAGCCGAGTT CGACCGCGTGTACGCGGTGAACATGAAGAGCCTGTTCTGGAGCGTGCAGACGTTCGTGCCGTATTTCCGCACGCAGGGCG GCGGCGTATTCGTGAACGTCGCCTCGACGGCCGGCGTGCGGCCGCGCCCGGGCCTCGTCTGGTACAACAGCACGAAAGGC GCGATGATCACCGCGAGCAAGTCGCTCGCGGCCGAGCTCGGCGCCGATCGCATCCGCGTGAACTGCATCAACCCGGTGCT CGGCGAGACCGCGCTGATGACCGAGTTCATGGGCTGCGAAGACACGCCCGAGAATCGCCGCCGCTTCCTCGCGACGATTC CGCTCGGCCGCTTCTCGACGCCGCAGGACATCGCGAACGCGGCGCTCTATCTCGCGTCCGACGAAGCCGAATTCATCACG GGCGTCTGCCTCGAAGTCGACGGCGGCCGCTGCATCTAG
Upstream 100 bases:
>100_bases ACGCGGGCGGCGACGCGCGCATCCGTGCGTGCCGCCCGCGATGCGTCGCATCGGCCACGCAGCAATACGACGACAACAGA TCGAACACAGGAGACACACC
Downstream 100 bases:
>100_bases CGCCCGCCGCTGCCGGACCCGGCGCGCGCGCGCCGGCATCGCTGCACCGCAATGCCAAGCACAACAACCGGCGCCGCACC CGCGCGCTGCCGGCTCACGA
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: 2,5-DDOL dehydrogenase [H]
Number of amino acids: Translated: 252; Mature: 252
Protein sequence:
>252_residues MRLSGKTAIVTGGGSGFGEGIAKTYAREGANVVVNDLNGAAAERVASEIALAGGKAIAVAGDVSRGDDWRALQQAALDDF HAVQIVVNNAGTTHRNKPVLDVTEAEFDRVYAVNMKSLFWSVQTFVPYFRTQGGGVFVNVASTAGVRPRPGLVWYNSTKG AMITASKSLAAELGADRIRVNCINPVLGETALMTEFMGCEDTPENRRRFLATIPLGRFSTPQDIANAALYLASDEAEFIT GVCLEVDGGRCI
Sequences:
>Translated_252_residues MRLSGKTAIVTGGGSGFGEGIAKTYAREGANVVVNDLNGAAAERVASEIALAGGKAIAVAGDVSRGDDWRALQQAALDDF HAVQIVVNNAGTTHRNKPVLDVTEAEFDRVYAVNMKSLFWSVQTFVPYFRTQGGGVFVNVASTAGVRPRPGLVWYNSTKG AMITASKSLAAELGADRIRVNCINPVLGETALMTEFMGCEDTPENRRRFLATIPLGRFSTPQDIANAALYLASDEAEFIT GVCLEVDGGRCI >Mature_252_residues MRLSGKTAIVTGGGSGFGEGIAKTYAREGANVVVNDLNGAAAERVASEIALAGGKAIAVAGDVSRGDDWRALQQAALDDF HAVQIVVNNAGTTHRNKPVLDVTEAEFDRVYAVNMKSLFWSVQTFVPYFRTQGGGVFVNVASTAGVRPRPGLVWYNSTKG AMITASKSLAAELGADRIRVNCINPVLGETALMTEFMGCEDTPENRRRFLATIPLGRFSTPQDIANAALYLASDEAEFIT GVCLEVDGGRCI
Specific function: Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=31.6, Blast_Score=118, Evalue=6e-27, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=33.7349397590361, Blast_Score=110, Evalue=9e-25, Organism=Homo sapiens, GI66933014, Length=250, Percent_Identity=32.8, Blast_Score=108, Evalue=5e-24, Organism=Homo sapiens, GI5031737, Length=249, Percent_Identity=30.5220883534137, Blast_Score=104, Evalue=8e-23, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.8537549407115, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=30.6201550387597, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI33667109, Length=228, Percent_Identity=30.2631578947368, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.0155642023346, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=31.1740890688259, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=29.8245614035088, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI4504505, Length=246, Percent_Identity=28.8617886178862, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI126723191, Length=209, Percent_Identity=30.622009569378, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=29.3172690763052, Blast_Score=84, Evalue=9e-17, Organism=Homo sapiens, GI210032110, Length=192, Percent_Identity=30.7291666666667, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI142976729, Length=186, Percent_Identity=27.9569892473118, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=29.3436293436293, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI31542939, Length=246, Percent_Identity=26.4227642276423, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI40807363, Length=201, Percent_Identity=26.3681592039801, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI310128830, Length=241, Percent_Identity=29.045643153527, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI310115468, Length=241, Percent_Identity=29.045643153527, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI302344755, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI4557649, Length=202, Percent_Identity=24.7524752475248, Blast_Score=68, Evalue=6e-12, Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=28.4, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI40254986, Length=163, Percent_Identity=26.3803680981595, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=39.3574297188755, Blast_Score=149, Evalue=1e-37, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=33.203125, Blast_Score=121, Evalue=4e-29, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=31.8548387096774, Blast_Score=114, Evalue=9e-27, Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=32.6693227091633, Blast_Score=108, Evalue=3e-25, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=32.6612903225806, Blast_Score=108, Evalue=3e-25, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=28.740157480315, Blast_Score=106, Evalue=1e-24, Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=27.8884462151394, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=31.25, Blast_Score=102, Evalue=3e-23, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=31.0077519379845, Blast_Score=99, Evalue=2e-22, Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=28.2258064516129, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=27.0916334661355, Blast_Score=68, Evalue=6e-13, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=25.2873563218391, Blast_Score=65, Evalue=6e-12, Organism=Escherichia coli, GI2367365, Length=257, Percent_Identity=26.0700389105058, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=31.3253012048193, Blast_Score=125, Evalue=2e-29, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=35.8870967741936, Blast_Score=120, Evalue=9e-28, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=34.9397590361446, Blast_Score=117, Evalue=7e-27, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32.4, Blast_Score=115, Evalue=3e-26, Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=30.3643724696356, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=37.0558375634518, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=31.6, Blast_Score=100, Evalue=5e-22, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=32, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=29.1666666666667, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=27.9850746268657, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=29.7794117647059, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=29.5880149812734, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=29.9242424242424, Blast_Score=96, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17564282, Length=175, Percent_Identity=32, Blast_Score=95, Evalue=4e-20, Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=30.1470588235294, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17508895, Length=173, Percent_Identity=34.6820809248555, Blast_Score=93, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560150, Length=270, Percent_Identity=28.5185185185185, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17559104, Length=263, Percent_Identity=28.8973384030418, Blast_Score=92, Evalue=4e-19, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=28.3018867924528, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=28.4644194756554, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17562990, Length=270, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=26.6917293233083, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=27.5092936802974, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=27.1698113207547, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=25.5639097744361, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=24.9056603773585, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17565030, Length=269, Percent_Identity=27.1375464684015, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI193203115, Length=190, Percent_Identity=28.4210526315789, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17567345, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI71982365, Length=200, Percent_Identity=25.5, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-18, Organism=Saccharomyces cerevisiae, GI6323882, Length=242, Percent_Identity=26.0330578512397, Blast_Score=66, Evalue=5e-12, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=34.5238095238095, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=33.203125, Blast_Score=124, Evalue=6e-29, Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=33.7301587301587, Blast_Score=119, Evalue=2e-27, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=33.4661354581673, Blast_Score=118, Evalue=4e-27, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=34.3873517786561, Blast_Score=116, Evalue=1e-26, Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=30.6451612903226, Blast_Score=110, Evalue=8e-25, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=32.6693227091633, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI281364892, Length=197, Percent_Identity=32.994923857868, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI24640492, Length=194, Percent_Identity=30.9278350515464, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24644337, Length=253, Percent_Identity=31.2252964426877, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=32.9896907216495, Blast_Score=91, Evalue=7e-19, Organism=Drosophila melanogaster, GI24649181, Length=188, Percent_Identity=30.3191489361702, Blast_Score=91, Evalue=8e-19, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=31.3725490196078, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI21357673, Length=251, Percent_Identity=26.6932270916335, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI21355631, Length=194, Percent_Identity=31.4432989690722, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI161076933, Length=182, Percent_Identity=28.021978021978, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24584748, Length=182, Percent_Identity=28.021978021978, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24640442, Length=186, Percent_Identity=31.7204301075269, Blast_Score=65, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 26721; Mature: 26721
Theoretical pI: Translated: 5.37; Mature: 5.37
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLSGKTAIVTGGGSGFGEGIAKTYAREGANVVVNDLNGAAAERVASEIALAGGKAIAVA CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEE GDVSRGDDWRALQQAALDDFHAVQIVVNNAGTTHRNKPVLDVTEAEFDRVYAVNMKSLFW CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHHHH SVQTFVPYFRTQGGGVFVNVASTAGVRPRPGLVWYNSTKGAMITASKSLAAELGADRIRV HHHHHHHHHEECCCEEEEEECCCCCCCCCCCEEEEECCCCEEEEECHHHHHHCCCCEEEE NCINPVLGETALMTEFMGCEDTPENRRRFLATIPLGRFSTPQDIANAALYLASDEAEFIT EECCCHHCCHHHHHHHCCCCCCCHHHHEEEEEECCCCCCCHHHHHHEEEEEECCCCCEEE GVCLEVDGGRCI EEEEEECCCCCC >Mature Secondary Structure MRLSGKTAIVTGGGSGFGEGIAKTYAREGANVVVNDLNGAAAERVASEIALAGGKAIAVA CCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEE GDVSRGDDWRALQQAALDDFHAVQIVVNNAGTTHRNKPVLDVTEAEFDRVYAVNMKSLFW CCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEECCCCCCEEEEEEHHHHHH SVQTFVPYFRTQGGGVFVNVASTAGVRPRPGLVWYNSTKGAMITASKSLAAELGADRIRV HHHHHHHHHEECCCEEEEEECCCCCCCCCCCEEEEECCCCEEEEECHHHHHHCCCCEEEE NCINPVLGETALMTEFMGCEDTPENRRRFLATIPLGRFSTPQDIANAALYLASDEAEFIT EECCCHHCCHHHHHHHCCCCCCCHHHHEEEEEECCCCCCCHHHHHHEEEEEECCCCCEEE GVCLEVDGGRCI EEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.085 {glycochenodeoxycholic} 0.24 {taurochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7515041; 12450824 [H]