Click here to switch to the map view.

The map label for this gene is ilvR [H]

Identifier: 161524012

GI number: 161524012

Start: 910264

End: 911178

Strand: Direct

Name: ilvR [H]

Synonym: Bmul_0833

Alternate gene names: 161524012

Gene position: 910264-911178 (Clockwise)

Preceding gene: 161524009

Following gene: 161524013

Centisome position: 26.4

GC content: 74.1

Gene sequence:

>915_bases
ATGGCCGAACCGACGCCCGACCTGCGCCAGTGGCGCTATTTCGTGACCGTCGCCGACGAGCGGCATTTCGGCCGCGCGGC
CGAGCGGCTGTCGATCACGCAGCCGCCGCTGTCGCAGGCGATCCGCGCGCTCGAGGACGCGCTCGGCGTCGCGCTGTTCG
CCCGCACGAAGCGCTCGGTCGCGCTGACGGCGGTCGGCGCGGCGCTTCTGCCCGACGTGCGGCGCCTCCTCGCGGCGGCC
GATGCGCTGCCGCCGCTTGCGCGGCGCCTCGCGCGCGGCGAGGCCGGTTCGCTCGCGCTCGCGTTCGTCTCGACGGCCGA
CTACGGGCTGCTGCCGTCGCTGCTGCGCGCATTCGGCGCGCGCTATCCGCAGGTCCGCCTGCAGCTCGCGGAAGCGACGA
GCGACGTGCAGATCGACGAGCTCGTCGCGGGCCGCATCGACGCGGGGCTCGTGATTCCGCCCGTGCCGCCGCGTCATGCG
GCCGGGCTGTCGTATCTGCCGGTCGTGCGCGAGCCGCTCGTCGTCGCGATGCCGGCGGGCGCGTCCGACGCGCCGGAAGA
CGCGCCCGTGCACCTCGCCGAGATCGCCGCGCTGCCGCTCGTGATCTTTCCGCGCCGTTTGGCGCCCGGCTTTTATGACA
TCATTACGGGCTGCTACGGCGCGGCCGGCGCGATACCGCGCATCGGCCAGGAGGCGATCCAGATGCAGACGATCGTCAGC
CTCGTGTCGGCCGGCATGGGCGTCGCACTGGTGCCGCAATCGCTGCGTAACCTGCGGCGCACCGGCGTGGTCTACCGGCC
GCTCGCCGGCGACGCGCCCGTCGTCGAGACGGGCCTCGTCTGGCGCACGGGCGACGTGAGCCCCGTGCTGGCCGCGTTCA
TCGAGGTCGTGCGTGCGCAGGCGCTCGCCGCCTGA

Upstream 100 bases:

>100_bases
CGCGCCGTACGGTGCGGCTCGAACAAGGATGGCGTTTCCGTTTTCGCGTGTCCAATATATTATTTGTCGCTTATTAAGTG
CTTTTGCGAATGAGTGAGCG

Downstream 100 bases:

>100_bases
CGTGAACGATGGCGCGCGTGTGCCGTCCAATGCGCGGTGCCGCGCGTCGGCGGGCGCCGTGCCGCATTCGAAAACTTCAT
CGCTAATCCATGATCATTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAEPTPDLRQWRYFVTVADERHFGRAAERLSITQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLAAA
DALPPLARRLARGEAGSLALAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHA
AGLSYLPVVREPLVVAMPAGASDAPEDAPVHLAEIAALPLVIFPRRLAPGFYDIITGCYGAAGAIPRIGQEAIQMQTIVS
LVSAGMGVALVPQSLRNLRRTGVVYRPLAGDAPVVETGLVWRTGDVSPVLAAFIEVVRAQALAA

Sequences:

>Translated_304_residues
MAEPTPDLRQWRYFVTVADERHFGRAAERLSITQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLAAA
DALPPLARRLARGEAGSLALAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHA
AGLSYLPVVREPLVVAMPAGASDAPEDAPVHLAEIAALPLVIFPRRLAPGFYDIITGCYGAAGAIPRIGQEAIQMQTIVS
LVSAGMGVALVPQSLRNLRRTGVVYRPLAGDAPVVETGLVWRTGDVSPVLAAFIEVVRAQALAA
>Mature_303_residues
AEPTPDLRQWRYFVTVADERHFGRAAERLSITQPPLSQAIRALEDALGVALFARTKRSVALTAVGAALLPDVRRLLAAAD
ALPPLARRLARGEAGSLALAFVSTADYGLLPSLLRAFGARYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAA
GLSYLPVVREPLVVAMPAGASDAPEDAPVHLAEIAALPLVIFPRRLAPGFYDIITGCYGAAGAIPRIGQEAIQMQTIVSL
VSAGMGVALVPQSLRNLRRTGVVYRPLAGDAPVVETGLVWRTGDVSPVLAAFIEVVRAQALAA

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=291, Percent_Identity=40.5498281786942, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1788887, Length=296, Percent_Identity=34.4594594594595, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI2367136, Length=299, Percent_Identity=32.7759197324415, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1790399, Length=300, Percent_Identity=29.3333333333333, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI145693105, Length=170, Percent_Identity=31.1764705882353, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787806, Length=295, Percent_Identity=27.7966101694915, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=28.8617886178862, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI157672245, Length=165, Percent_Identity=35.7575757575758, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=28.0632411067194, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787530, Length=246, Percent_Identity=28.4552845528455, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790208, Length=262, Percent_Identity=29.3893129770992, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=31.219512195122, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787589, Length=137, Percent_Identity=36.4963503649635, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=228, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=145, Percent_Identity=34.4827586206897, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI48994962, Length=71, Percent_Identity=46.4788732394366, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082132, Length=144, Percent_Identity=31.9444444444444, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=141, Percent_Identity=28.3687943262411, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32099; Mature: 31968

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPTPDLRQWRYFVTVADERHFGRAAERLSITQPPLSQAIRALEDALGVALFARTKRSV
CCCCCCCHHHEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ALTAVGAALLPDVRRLLAAADALPPLARRLARGEAGSLALAFVSTADYGLLPSLLRAFGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCC
RYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAG
CCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCCCCHHCCCCCHHHHHCCEEEEECCC
ASDAPEDAPVHLAEIAALPLVIFPRRLAPGFYDIITGCYGAAGAIPRIGQEAIQMQTIVS
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVSAGMGVALVPQSLRNLRRTGVVYRPLAGDAPVVETGLVWRTGDVSPVLAAFIEVVRAQ
HHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCEEECCCCCHHHHHHHHHHHHH
ALAA
HHCC
>Mature Secondary Structure 
AEPTPDLRQWRYFVTVADERHFGRAAERLSITQPPLSQAIRALEDALGVALFARTKRSV
CCCCCCHHHEEEEEEEECCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
ALTAVGAALLPDVRRLLAAADALPPLARRLARGEAGSLALAFVSTADYGLLPSLLRAFGA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCC
RYPQVRLQLAEATSDVQIDELVAGRIDAGLVIPPVPPRHAAGLSYLPVVREPLVVAMPAG
CCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEECCCCCCHHCCCCCHHHHHCCEEEEECCC
ASDAPEDAPVHLAEIAALPLVIFPRRLAPGFYDIITGCYGAAGAIPRIGQEAIQMQTIVS
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LVSAGMGVALVPQSLRNLRRTGVVYRPLAGDAPVVETGLVWRTGDVSPVLAAFIEVVRAQ
HHHCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCEEECCCCCHHHHHHHHHHHHH
ALAA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]