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The map label for this gene is ywrD [H]

Identifier: 161523804

GI number: 161523804

Start: 682956

End: 684596

Strand: Direct

Name: ywrD [H]

Synonym: Bmul_0624

Alternate gene names: 161523804

Gene position: 682956-684596 (Clockwise)

Preceding gene: 161523801

Following gene: 161523805

Centisome position: 19.8

GC content: 70.57

Gene sequence:

>1641_bases
ATGACTGATTTCAACTGGCACAACCCGTATCCGACGCCCCGCATCCCGGTGTTCGCGCGCAACGTCGTGTCGACGTCGCA
TCCGCTCGCCGCGCAGGCCGGGCTGCGGATGCTGTGGAAGGGCGGCAACGCGGTCGACGCGGCGCTCGCGGCCGCGGCCG
CGATCACGGTCGTCGAACCCGTCTCGTGCGGGCTCGGCGGCGATGCGTTCGCGCTCGTCTGGGACGGCGGCAAGCTGCAC
GGCCTGAACGCGTCGGGCGTCGCGCCGGCCGCGTGGAGCGTCGACTATTTCCGCCGGCGCCACGGCGAGGACGCGCACGG
CATCGCGCGCAAGCCGACGCGCGGCTGGGACACCGTCACGGTGCCCGGCGTGATCGCGGGCTGGGAAGCGCTGCATGCGA
AGTTCGGCTCGCTGCCGTTCGCGGACCTGCTCGAGCCGGCGATCGACATCGCGGAGCGCGGCTATTCGGTGTCGCCGATC
GTCGCGCACAAGTGGGCGGCCGCCGTGCCCGAGCTGCAGCGACTGCCCGGCTTCGCGGAGACCTTCATGCCGCGCGGCCG
CGCGCCGCTCGTCGGCGAGCGCATGTGCCTGCCCGGCCATGCGAAGACGCTGCGCACGCTCGCGAACGAAGGCGCGCGCG
CATTCTACGAAGGGGCGCTCGCCGCGCAGCTCGTCGCGTTCGCGCGCGAAGGCGGCGGCGCGCTGAGCGCGGAAGACTTG
CGCGCCTATCGCCCGGAATGGGTCGAGCCGATCGGCAAACGCTTCGGTCGCCATACGATTCACGAGATTCCGCCGAACGG
GCAGGGCATCGCCGCGCTGATCGCGCTCGGGATCGCCGAGCACGCGGGCGTGACCGACTGGCCCGTCGACTCGGCCGATT
CGCAGCATCTGCAGATCGAGGCGATGAAGCTCGCGTTCGCGGACGTCTACCGCTACGTTGCCGATCCGCGCGCGATGGAA
GTCACGCCCGAGCAGATGCTCGACGACGCCTATCTGGCGGCGCGCGCGAAGCAAATCGACCGCACGCGCGCGACGCAGTT
CGAGGCCGGCCGCCCGCATTCGGGCGGCACGATCTATCTGTCGGCCGCGGACGAACGCGGGATGATGGTCAGCTTCATCC
AGTCGAACTACATGGGCTTCGGCTCGGGCCTCGTCGTGCCCGGCGCGGGCATCGCGCTGCAGAACCGCGGGCACGGCTTC
TCGATGGACCCGGCGTCGCCGAACGTGGTGGCCGGCGGCAAGCGGCCGTTCCACACGATCATCCCGGCGTTCGTGACCGA
GGAGGCCGGCGGGCGCACGGAGGCCGTGATGAGTTTCGGCGTGATGGGCGGCGACATGCAGCCGCAGGGCCATCTGCAGA
CGATCGTCCGGATGCTCGGCTACGGGCAGCAGCCGCAGGCCGCGTGCTGCGCGCCGCGATGGAAGGTCAATCGCGACTTC
ACGCTCGACGTCGAAGCGACGATGGATCGCGCGACGGTCGAGGCGCTGGCCGCGCGCGGCCATACGATTAAGTCGATCGA
CGATCCTTACATGGATTTCGGCTCGGGCCAGTTCGTGTGGCGGCTCGATCCGGACGATCCCGATCGCGGCTACGTCGCCG
CGAGCGATAGCCGCCGCGACGGTCTCGCCGCCGGTTTCTGA

Upstream 100 bases:

>100_bases
CATTTCACAAATGAATTTGTGCGATTACGCCGATCGCGATGCAATGGCGGATTCCCCGCGCGCGGGGGCGCATTCCATTC
GTTTTCGACGAGGTAGACCG

Downstream 100 bases:

>100_bases
CGGATTCCTTTCCGCTGTCGCGATGCGCGGGCGGCCGAACGGCCGCCCGTTTCGCTCGGTGCGCGCGATTCGAATGACGC
GTCTAACATTCGGCAATGGA

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTDFNWHNPYPTPRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGGKLH
GLNASGVAPAAWSVDYFRRRHGEDAHGIARKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIDIAERGYSVSPI
VAHKWAAAVPELQRLPGFAETFMPRGRAPLVGERMCLPGHAKTLRTLANEGARAFYEGALAAQLVAFAREGGGALSAEDL
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTDWPVDSADSQHLQIEAMKLAFADVYRYVADPRAME
VTPEQMLDDAYLAARAKQIDRTRATQFEAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGAGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEAGGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
TLDVEATMDRATVEALAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPDRGYVAASDSRRDGLAAGF

Sequences:

>Translated_546_residues
MTDFNWHNPYPTPRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGGKLH
GLNASGVAPAAWSVDYFRRRHGEDAHGIARKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIDIAERGYSVSPI
VAHKWAAAVPELQRLPGFAETFMPRGRAPLVGERMCLPGHAKTLRTLANEGARAFYEGALAAQLVAFAREGGGALSAEDL
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTDWPVDSADSQHLQIEAMKLAFADVYRYVADPRAME
VTPEQMLDDAYLAARAKQIDRTRATQFEAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGAGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEAGGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
TLDVEATMDRATVEALAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPDRGYVAASDSRRDGLAAGF
>Mature_545_residues
TDFNWHNPYPTPRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEPVSCGLGGDAFALVWDGGKLHG
LNASGVAPAAWSVDYFRRRHGEDAHGIARKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIDIAERGYSVSPIV
AHKWAAAVPELQRLPGFAETFMPRGRAPLVGERMCLPGHAKTLRTLANEGARAFYEGALAAQLVAFAREGGGALSAEDLR
AYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTDWPVDSADSQHLQIEAMKLAFADVYRYVADPRAMEV
TPEQMLDDAYLAARAKQIDRTRATQFEAGRPHSGGTIYLSAADERGMMVSFIQSNYMGFGSGLVVPGAGIALQNRGHGFS
MDPASPNVVAGGKRPFHTIIPAFVTEEAGGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDFT
LDVEATMDRATVEALAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPDRGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=29.009009009009, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=29.009009009009, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=29.009009009009, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=29.009009009009, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI113429324, Length=555, Percent_Identity=27.9279279279279, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI113429326, Length=567, Percent_Identity=28.2186948853616, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI109148539, Length=545, Percent_Identity=28.8073394495413, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI153266885, Length=556, Percent_Identity=25.3597122302158, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI153266901, Length=557, Percent_Identity=25.4937163375224, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI153266907, Length=554, Percent_Identity=24.187725631769, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1789856, Length=558, Percent_Identity=29.2114695340502, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI72000294, Length=520, Percent_Identity=25.9615384615385, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI212646519, Length=520, Percent_Identity=25.9615384615385, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=522, Percent_Identity=24.1379310344828, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=541, Percent_Identity=24.0295748613678, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193208245, Length=516, Percent_Identity=25.968992248062, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI193208247, Length=516, Percent_Identity=25.968992248062, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24642670, Length=569, Percent_Identity=24.9560632688928, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24642666, Length=569, Percent_Identity=24.9560632688928, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI161077878, Length=569, Percent_Identity=24.9560632688928, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI161077880, Length=569, Percent_Identity=24.9560632688928, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45551474, Length=569, Percent_Identity=24.9560632688928, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI18859741, Length=530, Percent_Identity=26.9811320754717, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI18859893, Length=432, Percent_Identity=27.0833333333333, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077496, Length=513, Percent_Identity=27.2904483430799, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58570; Mature: 58439

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFNWHNPYPTPRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEP
CCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHEECC
VSCGLGGDAFALVWDGGKLHGLNASGVAPAAWSVDYFRRRHGEDAHGIARKPTRGWDTVT
CCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIDIAERGYSVSPIVAHKWAAAVPELQRLPGFAE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHH
TFMPRGRAPLVGERMCLPGHAKTLRTLANEGARAFYEGALAAQLVAFAREGGGALSAEDL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTDWPVDSADSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEH
AMKLAFADVYRYVADPRAMEVTPEQMLDDAYLAARAKQIDRTRATQFEAGRPHSGGTIYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGAGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEAGGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
TLDVEATMDRATVEALAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPDRGYVAASDSRRD
EEEHHHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCEEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC
>Mature Secondary Structure 
TDFNWHNPYPTPRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAAITVVEP
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHEECC
VSCGLGGDAFALVWDGGKLHGLNASGVAPAAWSVDYFRRRHGEDAHGIARKPTRGWDTVT
CCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIDIAERGYSVSPIVAHKWAAAVPELQRLPGFAE
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHH
TFMPRGRAPLVGERMCLPGHAKTLRTLANEGARAFYEGALAAQLVAFAREGGGALSAEDL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGVTDWPVDSADSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEH
AMKLAFADVYRYVADPRAMEVTPEQMLDDAYLAARAKQIDRTRATQFEAGRPHSGGTIYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGAGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEAGGRTEAVMSFGVMGGDMQPQGHLQTIVRMLGYGQQPQAACCAPRWKVNRDF
HHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCE
TLDVEATMDRATVEALAARGHTIKSIDDPYMDFGSGQFVWRLDPDDPDRGYVAASDSRRD
EEEHHHHHHHHHHHHHHHCCCEECCCCCCHHCCCCCEEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]