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The map label for this gene is ubiB [H]

Identifier: 161523750

GI number: 161523750

Start: 621518

End: 623095

Strand: Direct

Name: ubiB [H]

Synonym: Bmul_0570

Alternate gene names: 161523750

Gene position: 621518-623095 (Clockwise)

Preceding gene: 161523749

Following gene: 161523751

Centisome position: 18.02

GC content: 64.83

Gene sequence:

>1578_bases
ATGCGCATTTTCCGTTTCATCAAGATTGTCTATACCGTCATCCGCTTCGGGCTCGACGAGGTCATGCTGTCCCGGATCGA
CGACCGCCGCGTGAAACTGCTGCTGCGGATCACGACGATCGGCCGCCGCTATTCCGATCCGCCCGCCGTGCGGCTGCGTC
ATGCGCTCGAAAGCCTCGGTCCGATTTTCGTGAAGTTCGGCCAGGTGCTGTCGACGCGGCGCGATCTGCTGTCGGTCGAC
TTCGCGAACGAGCTCGCGAAACTGCAGGATCAGGTGCCGCCGTTCGATTCGTCGGTCGCGATCGCGATCATCGAGAAGTC
GCTCGGCGCGCCGGTCGACGAGCTGTTCGACGAATTCGAGCGCGAGCCCGTCGCGAGCGCGTCGATCGCGCAGGTGCACT
TCGCGAAACTGAAGCAGGGCGTGCATGCCGGCAAGGCCGTGGCGGTCAAGGTGCTGCGTCCGAACATGCTGCCCGTGATC
GATTCGGATCTCGCGCTGATGCGCGACATCGCGACGTGGACCGAGCGGATGTGGGCCGACGGACGCCGGCTGAAGCCGCG
CGAGGTCGTGGCCGAATTCGACAAGTATCTGCACGACGAGCTCGACCTGATGCGCGAGGCCGCGAACGGCAGCCAGCTGC
GCCGCAACTTCGCGGGCCTCGATCTGCTGCTCGTGCCGGAAATGTTCTGGGATTTCTCGACGTCGCACGTGCTCGTGATG
GAGCGCATGTCGGGCGTGCCGATCAGCCAGGTCGAGACGTTGCGCGCGGCCGGCGTCGACATCAAGAAGCTCGCGCGCGA
AGGCGTCGAGATTTTCTTCACGCAGGTGTTCCGCGACGGCTTTTTCCATGCGGACATGCATCCCGGCAACATTCAGGTCA
GCCTCGATCCGAACACGTTCGGCCGCTATATCGCGCTCGACTTCGGGATCGTCGGCGCGCTGTCCGACTTCGACAAGAAC
TATCTCGCGCAGAACTTCCTCGCGTTCTTCAAGCGCGACTATCACCGCGTCGCGACGCTGCACCTCGAGTCCGGCTGGGT
GCCGCCCGAAACGCGCGTCGAGGAACTCGAAAGCGCGATCCGCGCGGTCTGCGAGCCGTATTTCGACCGCGCGCTGAAGG
ACATTTCTCTCGGCCAGGTGCTGATGCGGCTGTTCTCGACGTCGCGCCGCTTCAACGTCGAAATCCAGCCGCAGCTCGTG
CTGCTGCAGAAGACGATGCTGAACGTCGAAGGGCTCGGCCGTTCGCTCGACCCGGAGCTCGATCTGTGGAAAACGGCGAA
GCCGTACCTGGAGCGCTGGATGACCGAGCAGATCGGTCTGCGCGGCTGGTACGAGCGCTTCAAGGTCGAAGCGCCGCAGT
GGAGCAAGACGATGCCGCAACTGCCGCGTCTCATTCACCACGCGCTCGCGGCCCGACACGATGCCCCGCGCGCGGCCAGC
GAAGACCTGATGCGGCAGATCCTGATCGAGCAGAAGCGGACCAACCGGCTGCTGCAGGCGCTGCTGATCTTCGGTCTCGC
GGTCGGCGTCGGCGCGCTCGTCGCCCGCGTGCTGCTCGCGCTCGCGTACGGCGCGTGA

Upstream 100 bases:

>100_bases
CGCGCTCGCACGTGTGGAGAAGCGGGTCGAGCGACTCGAACAAAAAATCGGCGCGCGCACGGGTTCCGGCCCGCGCGGCG
CGCACTGAGGGCCGCAGCGC

Downstream 100 bases:

>100_bases
CCGACAGGAGCGACGCGATGTCCGATCCGAAACACGCTGCCGCGCCGGCCGCCGCCTCGTTCGAAACGCGCGATCCGGGC
GACGCGTCGTTCTGGGACGA

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSSVAIAIIEKSLGAPVDELFDEFEREPVASASIAQVHFAKLKQGVHAGKAVAVKVLRPNMLPVI
DSDLALMRDIATWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSHVLVM
ERMSGVPISQVETLRAAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYIALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTMPQLPRLIHHALAARHDAPRAAS
EDLMRQILIEQKRTNRLLQALLIFGLAVGVGALVARVLLALAYGA

Sequences:

>Translated_525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSSVAIAIIEKSLGAPVDELFDEFEREPVASASIAQVHFAKLKQGVHAGKAVAVKVLRPNMLPVI
DSDLALMRDIATWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSHVLVM
ERMSGVPISQVETLRAAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYIALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTMPQLPRLIHHALAARHDAPRAAS
EDLMRQILIEQKRTNRLLQALLIFGLAVGVGALVARVLLALAYGA
>Mature_525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSSVAIAIIEKSLGAPVDELFDEFEREPVASASIAQVHFAKLKQGVHAGKAVAVKVLRPNMLPVI
DSDLALMRDIATWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSHVLVM
ERMSGVPISQVETLRAAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYIALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTMPQLPRLIHHALAARHDAPRAAS
EDLMRQILIEQKRTNRLLQALLIFGLAVGVGALVARVLLALAYGA

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=30.7971014492754, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI40254938, Length=262, Percent_Identity=30.5343511450382, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI217035081, Length=261, Percent_Identity=28.735632183908, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI32261307, Length=316, Percent_Identity=29.1139240506329, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI34147522, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI2367309, Length=472, Percent_Identity=52.9661016949153, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17559152, Length=278, Percent_Identity=30.2158273381295, Blast_Score=136, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=27.891156462585, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323282, Length=250, Percent_Identity=28, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=234, Percent_Identity=26.0683760683761, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI22024280, Length=272, Percent_Identity=31.25, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24662575, Length=317, Percent_Identity=28.7066246056782, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59859; Mature: 59859

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLG
CHHHHHHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
PIFVKFGQVLSTRRDLLSVDFANELAKLQDQVPPFDSSVAIAIIEKSLGAPVDELFDEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHHHHCCCHHHHHHHHC
REPVASASIAQVHFAKLKQGVHAGKAVAVKVLRPNMLPVIDSDLALMRDIATWTERMWAD
CCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
GRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSHVLVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
ERMSGVPISQVETLRAAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTF
HHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
GRYIALDFGIVGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHH
RAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPEL
HHHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
DLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTMPQLPRLIHHALAARHDAPRAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
EDLMRQILIEQKRTNRLLQALLIFGLAVGVGALVARVLLALAYGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLG
CHHHHHHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
PIFVKFGQVLSTRRDLLSVDFANELAKLQDQVPPFDSSVAIAIIEKSLGAPVDELFDEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEHHHHHCCCHHHHHHHHC
REPVASASIAQVHFAKLKQGVHAGKAVAVKVLRPNMLPVIDSDLALMRDIATWTERMWAD
CCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCC
GRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSHVLVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
ERMSGVPISQVETLRAAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTF
HHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
GRYIALDFGIVGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHH
RAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPEL
HHHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
DLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTMPQLPRLIHHALAARHDAPRAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHH
EDLMRQILIEQKRTNRLLQALLIFGLAVGVGALVARVLLALAYGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA