Click here to switch to the map view.

The map label for this gene is ctaB [H]

Identifier: 161523646

GI number: 161523646

Start: 507129

End: 508031

Strand: Direct

Name: ctaB [H]

Synonym: Bmul_0466

Alternate gene names: 161523646

Gene position: 507129-508031 (Clockwise)

Preceding gene: 161523645

Following gene: 161523647

Centisome position: 14.71

GC content: 66.0

Gene sequence:

>903_bases
ATGCAAAGCACCCTCTCCCAATCGCCCGGTAGCCGCTTTTCCCAGTACATGGCGCTGACGAAGCCGCGTGTCACGCAGCT
TGCGGTGTTCTGCGCGGTGATCGGCATGTTCCTCGCGACGCCGGGCATGGTGCCGTGGCATGTGCTGATCGGCGGCACGG
TCGGCATCTGGCTGCTGGCCGGCGCCGCGTTCGCGATCAACTGCCTCGTCGAACAGAAGGTCGACGCGATGATGCGCCGC
ACCGCGTGGCGCCCGTCCGCACGCGGCGAGATCACGACGCCGCAGATCCTGCTGTTCTCGGCCGTGCTCGGCAGCCTCGG
CGCATGGACGCTCTACACGTTCACGAACGCGCTGACGATGTGGCTGACGATCGCGACCTTCGTCGGCTACGCGGTGATCT
ACACGCTGCTGCTCAAGCCGATGACGCCGCAGAACATCGTGATCGGCGGTGCATCGGGCGCGATGCCGCCCGCGCTCGGC
TGGGCGGCGGTCACCGGCGCCGTGCCGGGCGACGCGTGGATCCTCGTGCTGATCATCTTCGTGTGGACGCCGCCGCATTT
CTGGGTGCTCGCGCTGTATCGCCGCAAGGATTACGAGAACGCGGGCCTGCCGATGCTGCCCGTCACGCACGGCGAGAAGT
TCACGCGGCTGCACATCCTGCTCTACACGGTGATCCTGTTCGCGGTCACGATGATGCCGTTCATCTCGGGGATGAGCGGC
GCCGTCTACCTGACGAGCGCGGTGCTGCTCGGCGCGGTGTTCCTCGCGTATGCGTGGAAGATCTACCGCGACTATTCGGA
CGAACTCGCCCGCAAGGCCTTCCGTTATTCGATCGTCTATCTGTCGCTGCTGTTTGCCGCGCTGCTCGCCGATCACTACG
CGCGCCCGCTGCTCGGCGTGTAA

Upstream 100 bases:

>100_bases
TGCTGCTGCTCGTCGTCATGTTAAACTTTCGCATCCTTTCAAGCCGCCCCGGCCGTGTCGTGCAGCCTGCGCGCGACGCC
GCCGCGGCGTGACCGTCCCC

Downstream 100 bases:

>100_bases
CCGCACGGTTTGAACGCAATGCTCCACTCATGGTTCGGGCGCCGCGCGCGCCAGCGCTGGGCGCTCGTCTGCGCATTCGC
GGCGGCGCTGCTGCTCGCCG

Product: protoheme IX farnesyltransferase

Products: heme O; pyrophosphate [C]

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKVDAMMRR
TAWRPSARGEITTPQILLFSAVLGSLGAWTLYTFTNALTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTMMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIYRDYSDELARKAFRYSIVYLSLLFAALLADHYARPLLGV

Sequences:

>Translated_300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKVDAMMRR
TAWRPSARGEITTPQILLFSAVLGSLGAWTLYTFTNALTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTMMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIYRDYSDELARKAFRYSIVYLSLLFAALLADHYARPLLGV
>Mature_300_residues
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLAGAAFAINCLVEQKVDAMMRR
TAWRPSARGEITTPQILLFSAVLGSLGAWTLYTFTNALTMWLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALG
WAAVTGAVPGDAWILVLIIFVWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTMMPFISGMSG
AVYLTSAVLLGAVFLAYAWKIYRDYSDELARKAFRYSIVYLSLLFAALLADHYARPLLGV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=34.8958333333333, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=32.1428571428571, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790473, Length=277, Percent_Identity=24.5487364620939, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71998235, Length=286, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6325085, Length=280, Percent_Identity=29.6428571428571, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI19921064, Length=292, Percent_Identity=30.4794520547945, Blast_Score=115, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32967; Mature: 32967

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLA
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAAFAINCLVEQKVDAMMRRTAWRPSARGEITTPQILLFSAVLGSLGAWTLYTFTNALTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
VWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTMMPFISGMSG
HHCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVYLTSAVLLGAVFLAYAWKIYRDYSDELARKAFRYSIVYLSLLFAALLADHYARPLLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQSTLSQSPGSRFSQYMALTKPRVTQLAVFCAVIGMFLATPGMVPWHVLIGGTVGIWLLA
CCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GAAFAINCLVEQKVDAMMRRTAWRPSARGEITTPQILLFSAVLGSLGAWTLYTFTNALTM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLTIATFVGYAVIYTLLLKPMTPQNIVIGGASGAMPPALGWAAVTGAVPGDAWILVLIIF
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
VWTPPHFWVLALYRRKDYENAGLPMLPVTHGEKFTRLHILLYTVILFAVTMMPFISGMSG
HHCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AVYLTSAVLLGAVFLAYAWKIYRDYSDELARKAFRYSIVYLSLLFAALLADHYARPLLGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protoheme; farnesyl-PP [C]

Specific reaction: protoheme + farnesyl-PP = heme O + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA