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The map label for this gene is hpd [H]

Identifier: 161523403

GI number: 161523403

Start: 250987

End: 252084

Strand: Reverse

Name: hpd [H]

Synonym: Bmul_0223

Alternate gene names: 161523403

Gene position: 252084-250987 (Counterclockwise)

Preceding gene: 161523405

Following gene: 161523401

Centisome position: 7.31

GC content: 62.93

Gene sequence:

>1098_bases
ATGCAGATCCCCACCTGGGACAACCCCGTCGGCACCGACGGCTTCGAATTCATCGAATACACGGCACCGGACCCGAAGGC
GCTCGGACAACTGTTCGAACGGATGGGTTTCACCGCGATCGCGCGTCACCGCCACAAGGACGTGACGGTCTACCGCCAGG
GCGACATCAACTTCATCATCAACGCCGAGCCCGACTCGTTCGCGCAGCGCTTCGCCCGGCTGCACGGCCCGTCGATCTGC
GCGATCGCGTTTCGCGTGCAGGACGCCGCGAAGGCGTACAAGCGCGCGCTCGAACTCGGCGCATGGGGCTTCGACAACAA
GACGGGCCCGATGGAGCTGAACATCCCGGCGATCAAGGGCATCGGCGATTCGCTGATCTACTTCGTCGACCGCTGGCGCG
GCAAGAACGGCGCGCAGCCGGGCGCGATCGGCGACATCAGCATCTACGACGTCGACTTCGAGCCGATCCCCGGCGCCGAG
CCGAACCCGGTCGGTCACGGGCTCACGTACATCGACCACCTGACGCACAACGTGCATCGCGGCCGCATGCAGGAATGGGC
GGAGTTCTACGAACGCCTGTTCAACTTCCGCGAAGTGCGCTACTTCGACATCGAAGGCAAGGTGACGGGTGTGAAGTCGA
AGGCGATGACGTCGCCGTGCGGCAAGATCCGCATCCCGATCAACGAGGAAGGCTCGGACACCGCCGGCCAGATCCAGGAA
TACCTGGACGCGTACCACGGCGAAGGCATTCAGCACATCGCGCTCGGCACCAACAACATCTATGGGGCGGTCGACGGCCT
GCGCAGCAAGGAAGTGAAGCTGCTCGACACGATCGACACCTATTACGAACTGGTCGATCGCCGCGTGCCGAACCACGGCG
AATCGCTGGAAGAGCTGAAGAAGCGCAAGATCCTGATCGACGGCGCACGCGACGATCTGCTGCTGCAGATCTTCACCGAA
AACCAGATCGGGCCGATCTTCTTCGAGATCATCCAGCGCAAGGGCAATCAGGGCTTCGGCGAGGGCAACTTCAAGGCGCT
GTTCGAATCGATCGAGCTCGATCAGATCCGCCGCGGCGTCGTGCAGGACAAGGCCTGA

Upstream 100 bases:

>100_bases
TGTCGCACGTACTCGATCGTTTCGCGCGCCATCGGCGCGCCCCCCCTCGACACAGGACCGACGGCGCTCCGCATCGCCGC
GGCCGACTCAGGAGACACGC

Downstream 100 bases:

>100_bases
CGCCAGGCCTGAGGGAACGGGCCGGTGCGCGCGGCCGCTCGCCGGTGTCCGGCCCCGGCCGCACAAACAAAAAGGGCGGG
AATCGCACGATTCCCGCCCT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGAE
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGTNNIYGAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLEELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Sequences:

>Translated_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGAE
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGTNNIYGAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLEELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA
>Mature_365_residues
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFIINAEPDSFAQRFARLHGPSIC
AIAFRVQDAAKAYKRALELGAWGFDNKTGPMELNIPAIKGIGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGAE
PNPVGHGLTYIDHLTHNVHRGRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
YLDAYHGEGIQHIALGTNNIYGAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLEELKKRKILIDGARDDLLLQIFTE
NQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGVVQDKA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=351, Percent_Identity=28.7749287749288, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI285002264, Length=348, Percent_Identity=28.448275862069, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI14249394, Length=378, Percent_Identity=24.6031746031746, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17555220, Length=205, Percent_Identity=38.0487804878049, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17550752, Length=223, Percent_Identity=30.9417040358744, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21356105, Length=301, Percent_Identity=33.8870431893688, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24667510, Length=301, Percent_Identity=33.8870431893688, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 41177; Mature: 41177

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYKRALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGAEPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYHGEGIQHIALGTNNIYGAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLEELK
HHHHHCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KRKILIDGARDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC
>Mature Secondary Structure
MQIPTWDNPVGTDGFEFIEYTAPDPKALGQLFERMGFTAIARHRHKDVTVYRQGDINFII
CCCCCCCCCCCCCCHHEEEECCCCHHHHHHHHHHHCHHHHHHHCCCCEEEEEECCEEEEE
NAEPDSFAQRFARLHGPSICAIAFRVQDAAKAYKRALELGAWGFDNKTGPMELNIPAIKG
ECCCHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHC
IGDSLIYFVDRWRGKNGAQPGAIGDISIYDVDFEPIPGAEPNPVGHGLTYIDHLTHNVHR
CCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSDTAGQIQE
HHHHHHHHHHHHHHCHHHEEEEEECCEEECCCHHHHCCCCCEEEEECCCCCCCHHHHHHH
YLDAYHGEGIQHIALGTNNIYGAVDGLRSKEVKLLDTIDTYYELVDRRVPNHGESLEELK
HHHHHCCCCEEEEEECCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KRKILIDGARDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
HCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHHH
VQDKA
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]