Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 161523337

GI number: 161523337

Start: 178058

End: 178804

Strand: Reverse

Name: aqpZ [H]

Synonym: Bmul_0157

Alternate gene names: 161523337

Gene position: 178804-178058 (Counterclockwise)

Preceding gene: 161523339

Following gene: 161523334

Centisome position: 5.19

GC content: 68.01

Gene sequence:

>747_bases
ATGAATCTTTCTCAGCGGCTCGCTGCAGAGGTATTCGGCACGTTCTGGCTGGTGCTCGGCGGGTGCGGCAGCGCCGTGCT
GGCCGCCGCCTTCCCGGGCCTCGGCATCGGATTTGCCGGCGTCGCGCTCGCCTTCGGGCTGACGGTTCTGACGATGGCGT
TCGCGATCGGCCACATTTCGGGCTGCCATCTGAATCCGGCCGTGAGCGTCGGCCTGACGGTCGCCGGGCGCTTCCCGGCA
CGCGACCTCGTCCCGTACATCGTCGCGCAGGTGGTGGGCGCAACGATCGGCGCGTTCGTGCTGTATCTGATCGCGACCGG
CAAGCCGGGTTTCGACGTCGTCGGCAGCGGCTTCGCGACGAACGGTTTCGGCGAGCGCTCGCCGGGCCACTACTCGCTCG
CCGCGTCGTTCATCTGCGAAGTCGTGATGACGGGCTTCTTCCTGTTCGTGATCCTCGGCGCGACCGACAAGCGCGGCGTG
CCGGCAGGCTTCGCGCCGATCGCGATCGGGCTGTGCCTGACGCTGATTCACCTGATCTCGATTCCGGTCACCAACACGTC
CGTGAACCCCGCTCGTTCGACCGGCCCGGCGCTGTTCGTCGGCGGCGATGCGATCGGCCAGCTCTGGCTGTTCTGGATCG
CGCCGCTGATCGGTGCGGCGCTCGCCGGCGTCATCTACCCGCTGGTGGCGGGCCGCGACGATGCGATCGACCTGCTGCCG
ACGGCATCCGCTCGCACAAGCGAATAA

Upstream 100 bases:

>100_bases
ATGCGGCGTTTCATTTCCTATAATCCAGACCAATTCCGGACGGCGGCTAAATCGTAACCGTCGCCGGTTTGTCTTCAACC
CACTTGAACGAGGTCCTCAC

Downstream 100 bases:

>100_bases
CCACTACGGGGTCATGCGAGCAGAGCAGCGAGCCTCACGCTGCACAAGAAGATAGAGGCAAGCCATTTGACGGGCGCCGC
TGGCGCCCGTTTTTCATGTC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATIGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLAASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWIAPLIGAALAGVIYPLVAGRDDAIDLLP
TASARTSE

Sequences:

>Translated_248_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATIGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLAASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWIAPLIGAALAGVIYPLVAGRDDAIDLLP
TASARTSE
>Mature_248_residues
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHISGCHLNPAVSVGLTVAGRFPA
RDLVPYIVAQVVGATIGAFVLYLIATGKPGFDVVGSGFATNGFGERSPGHYSLAASFICEVVMTGFFLFVILGATDKRGV
PAGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTGPALFVGGDAIGQLWLFWIAPLIGAALAGVIYPLVAGRDDAIDLLP
TASARTSE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4755125, Length=190, Percent_Identity=38.4210526315789, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4502181, Length=190, Percent_Identity=38.4210526315789, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI37694062, Length=190, Percent_Identity=36.3157894736842, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=34.2465753424658, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4502179, Length=227, Percent_Identity=33.920704845815, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI6912506, Length=219, Percent_Identity=32.8767123287671, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI157266307, Length=245, Percent_Identity=31.0204081632653, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI86792455, Length=231, Percent_Identity=32.034632034632, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI22538420, Length=272, Percent_Identity=30.1470588235294, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4826645, Length=248, Percent_Identity=31.4516129032258, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4502187, Length=273, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI45446752, Length=209, Percent_Identity=29.1866028708134, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=70.6730769230769, Blast_Score=285, Evalue=1e-78,
Organism=Escherichia coli, GI1790362, Length=269, Percent_Identity=28.996282527881, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71992966, Length=266, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71993722, Length=243, Percent_Identity=31.6872427983539, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=206, Percent_Identity=30.0970873786408, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992961, Length=265, Percent_Identity=27.9245283018868, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994009, Length=238, Percent_Identity=27.7310924369748, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531429, Length=252, Percent_Identity=29.7619047619048, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531431, Length=252, Percent_Identity=29.7619047619048, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=201, Percent_Identity=27.363184079602, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24652747, Length=240, Percent_Identity=35, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45551084, Length=240, Percent_Identity=35, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24652751, Length=238, Percent_Identity=30.672268907563, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922038, Length=238, Percent_Identity=30.672268907563, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24762342, Length=215, Percent_Identity=30.6976744186047, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45550503, Length=245, Percent_Identity=27.7551020408163, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24762346, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762348, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130305, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24762344, Length=227, Percent_Identity=30.8370044052863, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17136672, Length=224, Percent_Identity=28.125, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 25221; Mature: 25221

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLVPYIVAQVVGATIGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGERSPGHYSLAASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWIAPLIGAALAGVIYPLVAGRDDAIDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
TASARTSE
CCCCCCCC
>Mature Secondary Structure
MNLSQRLAAEVFGTFWLVLGGCGSAVLAAAFPGLGIGFAGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSVGLTVAGRFPARDLVPYIVAQVVGATIGAFVLYLIATGKPGFDVVGSGFAT
CCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCC
NGFGERSPGHYSLAASFICEVVMTGFFLFVILGATDKRGVPAGFAPIAIGLCLTLIHLIS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IPVTNTSVNPARSTGPALFVGGDAIGQLWLFWIAPLIGAALAGVIYPLVAGRDDAIDLLP
CCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
TASARTSE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]