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The map label for this gene is gcvT [H]

Identifier: 161523323

GI number: 161523323

Start: 160011

End: 161129

Strand: Reverse

Name: gcvT [H]

Synonym: Bmul_0143

Alternate gene names: 161523323

Gene position: 161129-160011 (Counterclockwise)

Preceding gene: 161523324

Following gene: 161523322

Centisome position: 4.67

GC content: 67.56

Gene sequence:

>1119_bases
ATGACTGCACTGAAACATACCCCGCTCAACGCCGCGCATCGCGCACTCAATGCCCGCATGGTCGACTTCGGCGGCTGGGA
CATGCCCGTCAACTACGGCTCGCAGATCGAAGAGCACGAAGCGGTGCGCACCGACGCCGGCATGTTCGACGTGTCGCACA
TGTGCGTCGTCGATTTCACCGGCAGCCGCGCGCGCGCCTTCTTCGAGTACGCGATCGCGAACAACGTCGGCAAGCTCAAG
ACGCCCGGCAAGGCGCTCTACTCGTGCCTGCTCAATCCGCAGGGCGGCGTCATCGACGATCTGATCGTCTATTACTTCAC
CGAAGACTTCTTCCGCGTGGTCGTCAACGCCGGCACCGCCGACAAGGACATCGCCTGGTTCAACCAGCTCAACGAGCAAG
GCGGCTACGGGCTCACGATCGCGCCGCGCCGCGATTTCGCGATCGTCGCCGTACAGGGTCCGAACGCGCGCGAAAAGGTC
TGGGCGACCGTGCCCGCCGCGCGCGCCGCGACGAGCGAGCTGAAGCCGTTCAATGCCGCGCAGGTCGCCGGCACGCCGTT
CGGCGATCTGACGGTCGCCCGCACCGGCTACACGGGCGAGGACGGCTTCGAAGTGATCGTCCCGGCCGTGCACGTCGAGG
CGCTGTGGAACGCGCTGCAGCAGCACGGCGTGCGTCCGTGCGGGCTCGGCGCGCGCGACACGCTGCGGCTCGAAGCCGGC
ATGAACCTGTACGGCCAGGACATGGACGACACCGTCTCGCCGCTCGACGCAGGCCTCGCCTGGACGGTCGACCTGTCGAC
GCCGCGCGCGTTCGTCGGCCGCGAAGCGCTCGAGCGCGACGGCACGCGCGCCGCATTCGTCGGCCTGATCCTGCAGAAGG
AAAACGGCAAGGCGGGCGGCGTGCTGCGCGCGCACCAGAAGGTCGTCACGCCGCACGGCGAAGGGGAGATCACGAGCGGC
ACGTTCTCGCCGTCGATGCAGGAATCGATCGCGTTCGCGCGCGTGCCGACGGCCGTCCAGGTCGGCGACACCGTCCATGT
GCAGATTCGTGACAAGCAACTTCCCGCGCGCGTGGTAAAACTGCCGTTCGTGCGCAACGGCAAGGTCCTCGCTGCGTAA

Upstream 100 bases:

>100_bases
GGACAGAGGGGCATGTACAGGATCGCTCGCCGGCCCATCGCCGCAGCGGTCGGCACATGGCCGTTCTGATCCGCGCGCAA
GCGCCTTGCCTGAGGCCTCG

Downstream 100 bases:

>100_bases
CGACCGGGAGTGCCTCCCGGTTCGCCGGGATATGGCGCCCGGCAAAACAACCGCATCGGCGCGCCCGCCCGGCGCGCCGG
CACAACGAATCACACTTTTA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTALKHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRARAFFEYAIANNVGKLK
TPGKALYSCLLNPQGGVIDDLIVYYFTEDFFRVVVNAGTADKDIAWFNQLNEQGGYGLTIAPRRDFAIVAVQGPNAREKV
WATVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQHGVRPCGLGARDTLRLEAG
MNLYGQDMDDTVSPLDAGLAWTVDLSTPRAFVGREALERDGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSG
TFSPSMQESIAFARVPTAVQVGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA

Sequences:

>Translated_372_residues
MTALKHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRARAFFEYAIANNVGKLK
TPGKALYSCLLNPQGGVIDDLIVYYFTEDFFRVVVNAGTADKDIAWFNQLNEQGGYGLTIAPRRDFAIVAVQGPNAREKV
WATVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQHGVRPCGLGARDTLRLEAG
MNLYGQDMDDTVSPLDAGLAWTVDLSTPRAFVGREALERDGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSG
TFSPSMQESIAFARVPTAVQVGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA
>Mature_371_residues
TALKHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFTGSRARAFFEYAIANNVGKLKT
PGKALYSCLLNPQGGVIDDLIVYYFTEDFFRVVVNAGTADKDIAWFNQLNEQGGYGLTIAPRRDFAIVAVQGPNAREKVW
ATVPAARAATSELKPFNAAQVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQHGVRPCGLGARDTLRLEAGM
NLYGQDMDDTVSPLDAGLAWTVDLSTPRAFVGREALERDGTRAAFVGLILQKENGKAGGVLRAHQKVVTPHGEGEITSGT
FSPSMQESIAFARVPTAVQVGDTVHVQIRDKQLPARVVKLPFVRNGKVLAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=380, Percent_Identity=35.7894736842105, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI257796258, Length=352, Percent_Identity=35.5113636363636, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=35, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI257796254, Length=373, Percent_Identity=31.0991957104558, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI24797151, Length=340, Percent_Identity=28.8235294117647, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI197927446, Length=349, Percent_Identity=24.9283667621776, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI21361378, Length=349, Percent_Identity=24.9283667621776, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1789272, Length=377, Percent_Identity=53.5809018567639, Blast_Score=372, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17560118, Length=380, Percent_Identity=33.4210526315789, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994045, Length=345, Percent_Identity=23.1884057971014, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994052, Length=345, Percent_Identity=23.1884057971014, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320222, Length=389, Percent_Identity=33.4190231362468, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI20129441, Length=381, Percent_Identity=32.8083989501312, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI28571104, Length=273, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130091, Length=303, Percent_Identity=24.7524752475248, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40165; Mature: 40034

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALKHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFT
CCCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEECCEEEEEEEC
GSRARAFFEYAIANNVGKLKTPGKALYSCLLNPQGGVIDDLIVYYFTEDFFRVVVNAGTA
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCC
DKDIAWFNQLNEQGGYGLTIAPRRDFAIVAVQGPNAREKVWATVPAARAATSELKPFNAA
CCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHEEEECCHHHHHHHHCCCCCCH
QVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQHGVRPCGLGARDTLRLEAG
HCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
MNLYGQDMDDTVSPLDAGLAWTVDLSTPRAFVGREALERDGTRAAFVGLILQKENGKAGG
CCCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCC
VLRAHQKVVTPHGEGEITSGTFSPSMQESIAFARVPTAVQVGDTVHVQIRDKQLPARVVK
EEEECCEEECCCCCCCEECCCCCCCHHHHHHHHCCCCEEEECCEEEEEEECCCCCCEEEE
LPFVRNGKVLAA
CCEEECCCEEEC
>Mature Secondary Structure 
TALKHTPLNAAHRALNARMVDFGGWDMPVNYGSQIEEHEAVRTDAGMFDVSHMCVVDFT
CCCCCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCEECCEEEEEEEC
GSRARAFFEYAIANNVGKLKTPGKALYSCLLNPQGGVIDDLIVYYFTEDFFRVVVNAGTA
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEECCCC
DKDIAWFNQLNEQGGYGLTIAPRRDFAIVAVQGPNAREKVWATVPAARAATSELKPFNAA
CCHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCHHHEEEECCHHHHHHHHCCCCCCH
QVAGTPFGDLTVARTGYTGEDGFEVIVPAVHVEALWNALQQHGVRPCGLGARDTLRLEAG
HCCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECC
MNLYGQDMDDTVSPLDAGLAWTVDLSTPRAFVGREALERDGTRAAFVGLILQKENGKAGG
CCCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCC
VLRAHQKVVTPHGEGEITSGTFSPSMQESIAFARVPTAVQVGDTVHVQIRDKQLPARVVK
EEEECCEEECCCCCCCEECCCCCCCHHHHHHHHCCCCEEEECCEEEEEEECCCCCCEEEE
LPFVRNGKVLAA
CCEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA