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The map label for this gene is xapR [H]

Identifier: 161523261

GI number: 161523261

Start: 85253

End: 86191

Strand: Reverse

Name: xapR [H]

Synonym: Bmul_0081

Alternate gene names: 161523261

Gene position: 86191-85253 (Counterclockwise)

Preceding gene: 161523290

Following gene: 161523260

Centisome position: 2.5

GC content: 70.93

Gene sequence:

>939_bases
ATGCTCAACTGCGTTATAAGCGGCGCTCATATCACGACGATGGATCTCACCCTGCTACGCGCGTTCGCGACGGTCGCCCG
CGAAGGCAATCTGACGCGCGCGGCCGCGCAGCTGCATCTGACGCAGCCCGCGGTGAGCCTGCAGATCAAGCATCTGCAGG
AGACGCTCGGCGTCGCGCTGTTCACGCGCACGTCGCGCGGGCTCGCGCTCACGCGCGACGGCCAGACGCTGCTGCCCCAC
GCGGAACGCGCGCTCGCGGCGGCGGCCGACGTCGAGCGTGCGGCGGCCGCGCTGCGGCACGAGGTGCGCGGCCGGCTGCG
GATCGGCACGATCCTCGATCCGGGCTTTCTGCGGCTCGGCGGCTTTCTGCGCGCGCTCGTCGAAACCCACCCGCAAATCG
AGACCGCGCTGCGGCACGGGATGTCGGGCTGGGTGCTCGACCAGGTGCGTGCGCAGGCGCTCGATGTCGGCTACTACATC
GGCCGGCCCGGCGACGACGATCCGCGCGACGGTGCGCCGTTCCATACGGTCACGCTCACGCATTTCCAGTACCGCGTGCT
CGCACCGGCCGGCTGGAAGGAGCGCGTGCAGCGCGCGCACGACTGGCGCGCGCTCGCCGCGCTGCCGTGGATCTGGGCGC
CGCCCGCGTCGGCGCACAACCGGCTGCTGTCGCGATGCTTCGCACAGGCCGGCGTGCAGCCGCTGAAGGTCGCCGAAGTC
GATCAGGAGCAGTCGATGCTCGATCTCGTGAAATCGGGGATCGGTCTGACGCTCGCGCGCGACGCGATCGCGCTCGCCGA
AGCGCACGCGCATGCGCTGACGATCGTCGAGCGCGTGACGGTGCCGACCGAGCTGACCTTCGTCACGCTCGCCGAGCGGC
GCGACGAACCGGCCATCGCGGCCGCGCTCCGGCTGATCGAAGCGCAGTGGGCAATATGA

Upstream 100 bases:

>100_bases
GCGACGCCGCAATCGCCGCCGCGCCGTGCGCGTCCGTCACACGGCGCGGAACGCGACCGATGAAGCGTACTCCCGGCGCC
CACCGCCGATCCAATGAGTT

Downstream 100 bases:

>100_bases
GCGCGATTGATGATGCGGGCCGCCGCGCGCGCCGCGCGCTGCGCTTCGGCGCGGCGGGCTTCACGTCGCCGTCGCAGCCT
TTTTGCTAGATTGTGCGTTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLNCVISGAHITTMDLTLLRAFATVAREGNLTRAAAQLHLTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVERAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVLDQVRAQALDVGYYI
GRPGDDDPRDGAPFHTVTLTHFQYRVLAPAGWKERVQRAHDWRALAALPWIWAPPASAHNRLLSRCFAQAGVQPLKVAEV
DQEQSMLDLVKSGIGLTLARDAIALAEAHAHALTIVERVTVPTELTFVTLAERRDEPAIAAALRLIEAQWAI

Sequences:

>Translated_312_residues
MLNCVISGAHITTMDLTLLRAFATVAREGNLTRAAAQLHLTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVERAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVLDQVRAQALDVGYYI
GRPGDDDPRDGAPFHTVTLTHFQYRVLAPAGWKERVQRAHDWRALAALPWIWAPPASAHNRLLSRCFAQAGVQPLKVAEV
DQEQSMLDLVKSGIGLTLARDAIALAEAHAHALTIVERVTVPTELTFVTLAERRDEPAIAAALRLIEAQWAI
>Mature_312_residues
MLNCVISGAHITTMDLTLLRAFATVAREGNLTRAAAQLHLTQPAVSLQIKHLQETLGVALFTRTSRGLALTRDGQTLLPH
AERALAAAADVERAAAALRHEVRGRLRIGTILDPGFLRLGGFLRALVETHPQIETALRHGMSGWVLDQVRAQALDVGYYI
GRPGDDDPRDGAPFHTVTLTHFQYRVLAPAGWKERVQRAHDWRALAALPWIWAPPASAHNRLLSRCFAQAGVQPLKVAEV
DQEQSMLDLVKSGIGLTLARDAIALAEAHAHALTIVERVTVPTELTFVTLAERRDEPAIAAALRLIEAQWAI

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=258, Percent_Identity=28.6821705426357, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787806, Length=246, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI157672245, Length=253, Percent_Identity=29.6442687747036, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=25.7425742574257, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=157, Percent_Identity=31.2101910828025, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=255, Percent_Identity=26.2745098039216, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787601, Length=156, Percent_Identity=30.1282051282051, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994962, Length=73, Percent_Identity=46.5753424657534, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1786448, Length=196, Percent_Identity=29.0816326530612, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1790399, Length=143, Percent_Identity=30.0699300699301, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787879, Length=117, Percent_Identity=35.042735042735, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1787589, Length=152, Percent_Identity=32.2368421052632, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34095; Mature: 34095

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNCVISGAHITTMDLTLLRAFATVAREGNLTRAAAQLHLTQPAVSLQIKHLQETLGVAL
CCEEEEECCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTRTSRGLALTRDGQTLLPHAERALAAAADVERAAAALRHEVRGRLRIGTILDPGFLRLG
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
GFLRALVETHPQIETALRHGMSGWVLDQVRAQALDVGYYIGRPGDDDPRDGAPFHTVTLT
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCCEEEEEEE
HFQYRVLAPAGWKERVQRAHDWRALAALPWIWAPPASAHNRLLSRCFAQAGVQPLKVAEV
EEEEEEECCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCEEEHHC
DQEQSMLDLVKSGIGLTLARDAIALAEAHAHALTIVERVTVPTELTFVTLAERRDEPAIA
CHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCHHHH
AALRLIEAQWAI
HHHHHHHHHCCC
>Mature Secondary Structure
MLNCVISGAHITTMDLTLLRAFATVAREGNLTRAAAQLHLTQPAVSLQIKHLQETLGVAL
CCEEEEECCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
FTRTSRGLALTRDGQTLLPHAERALAAAADVERAAAALRHEVRGRLRIGTILDPGFLRLG
EEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
GFLRALVETHPQIETALRHGMSGWVLDQVRAQALDVGYYIGRPGDDDPRDGAPFHTVTLT
HHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCEEECCCCCCCCCCCCCEEEEEEE
HFQYRVLAPAGWKERVQRAHDWRALAALPWIWAPPASAHNRLLSRCFAQAGVQPLKVAEV
EEEEEEECCCCHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHCCCCEEEHHC
DQEQSMLDLVKSGIGLTLARDAIALAEAHAHALTIVERVTVPTELTFVTLAERRDEPAIA
CHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCHHHH
AALRLIEAQWAI
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]