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The map label for this gene is oprM [H]

Identifier: 161523231

GI number: 161523231

Start: 54348

End: 55931

Strand: Direct

Name: oprM [H]

Synonym: Bmul_0051

Alternate gene names: 161523231

Gene position: 54348-55931 (Clockwise)

Preceding gene: 161523230

Following gene: 161523240

Centisome position: 1.58

GC content: 71.34

Gene sequence:

>1584_bases
ATGCCGTACGCCCCACTCCCGCGCGCCCTCCGCCCGCTGAGCGCCGCCGTCGCCGTCGCGACGGCCGTGCTGCTCGCCGG
CTGCGCCGTCGGGCCCGATTACCACCGCCCCGATACGTCGATTCCGGCCGCGTTCAAGGAAGCGCCCGCGGGCTGGAAAG
TCGCGCAGCCTGCCGACCGTGCCGATCGCGGCCCGTGGTGGACCGTCTACGACGATCCGCAGCTGAACGCGCTGATCGAC
AAGCTGAACGCGTCGAACCAGACGATCGCGCAATCGGCGGCCGCCTACCGTCAGGCGCGCGCGCTCGTCAGCGAGGCGCG
CGCCGCGTATTTCCCGACCGTCGGCCTGAGCGCGTCCGGCTCGCGCGCGCGCACGCCGCGCTCGTCGTTCTCGTCGGGCA
CCTCGTCATCGTTCGGCAGCAGCACGTCGGGATCGATCAACAACAGCTACAGCGTCGGCCTCGATGCGAGCTGGGAACCC
GATCTGTGGGGCAAGGTGAGCCGCACCGTCAGCGCGCAGCGTGCCGGCGAAGCGGCGGCCGCGGCCGATCTCGCGAATGC
GCGGCTGTCGCAGCAGGCGCTGCTCGCGCAGACCTACTTCCAGCTGCGCACGTCCGATGCGCTGCAGAAGCTGCTCGACG
AAACCGTGCAGTCGTACCGGCAATCGCTGCAGCTCACGCAAAACCAGTATGCGCAGGGTGTCGCCGCGCGCGCGGACGTG
ATCCAGGCGCAGACGCAGCTGCAAAGCGCACAGGCCGCCGCGATCGACAACGGCGTCGCGCGCGCGCAGTACGAGCATGC
GATCGCGACGCTGATCGGCGAGCCCGCGTCGACGTTCTCGCTGCCGCCGATGCCGCTCACGGCCGAGCCGCCCATCACGC
CGGTCGACGTGCCGTCCACGCTGCTCGAGCGCCGGCCCGACATCGCGGCGGCCGAACGCCGCGCGGCGGCCGCGAACGAG
CAGATCGGCGTCGCGATCTCCGCGTTCTTCCCGACGCTCACGCTGTCGGCGAGCGGCGGTTTCGAAAGCTCGGTCTGGTC
GCAGCTGTTCACGCTGCCGGCGCGTTTCTGGACGGTCGGCCCGCAGCTCGCGGCGACGCTGTTCGACGCGGGGCTGCGCG
CCGCGCAAACGCAGGCCGCGCGCGCGACCTACGATCAGGACGTCGCCGCATACCGGCTCGCGGTGCTGAGCGCGTTCCAG
GACGTCGAGGACAACCTCGCGTCGCAGCGGATTCTCGCGCAGGAAATCGACGTGCAGCGACAGGCGGTCGAGAGCGCCGA
GCATGCGCTCGCGATCGTCACGAATCAGTACAAGGCTGGCACCGTCGCGTATCTGAACGTGCTGACCGCGCAGACGACGG
CCTTCACCGCGCGCCAGAAGCTCGCGACGATCACCGGGCAGCGGATGGTGTCGTCCGTCGGACTCGTGAAGGCGCTCGGC
GGCGGCTGGAACGTGTCGGATATCGCGCGCGAGACGGGCGACATGGCGGCGCCGGCGGCCGTGCCGGCATCCGGTGCAGC
CGCTGCGTCGGCCGTATCAGCCGTGTCGGCCGCGCCCGCGCCCGGCACGCTCGCGCGCCAATAA

Upstream 100 bases:

>100_bases
CAGGCTCCCCGCCGTCAGTTACCATTTGTCCGCCAGCGGCATGACGTCCGCACCGCGCGGCGCCGCTCGCGGCCCGTTGC
GCCCAGACAGGAAAAATACG

Downstream 100 bases:

>100_bases
GTCACCGCCATCGGCAGGCCGCGCCGCGCCGTGTGCGGCGCTCGCTCAGCGCATCGCGCCGCCGTAGATCAGCGACACCT
GGCCGTTGCCGATCGGGCGG

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPYAPLPRALRPLSAAVAVATAVLLAGCAVGPDYHRPDTSIPAAFKEAPAGWKVAQPADRADRGPWWTVYDDPQLNALID
KLNASNQTIAQSAAAYRQARALVSEARAAYFPTVGLSASGSRARTPRSSFSSGTSSSFGSSTSGSINNSYSVGLDASWEP
DLWGKVSRTVSAQRAGEAAAAADLANARLSQQALLAQTYFQLRTSDALQKLLDETVQSYRQSLQLTQNQYAQGVAARADV
IQAQTQLQSAQAAAIDNGVARAQYEHAIATLIGEPASTFSLPPMPLTAEPPITPVDVPSTLLERRPDIAAAERRAAAANE
QIGVAISAFFPTLTLSASGGFESSVWSQLFTLPARFWTVGPQLAATLFDAGLRAAQTQAARATYDQDVAAYRLAVLSAFQ
DVEDNLASQRILAQEIDVQRQAVESAEHALAIVTNQYKAGTVAYLNVLTAQTTAFTARQKLATITGQRMVSSVGLVKALG
GGWNVSDIARETGDMAAPAAVPASGAAAASAVSAVSAAPAPGTLARQ

Sequences:

>Translated_527_residues
MPYAPLPRALRPLSAAVAVATAVLLAGCAVGPDYHRPDTSIPAAFKEAPAGWKVAQPADRADRGPWWTVYDDPQLNALID
KLNASNQTIAQSAAAYRQARALVSEARAAYFPTVGLSASGSRARTPRSSFSSGTSSSFGSSTSGSINNSYSVGLDASWEP
DLWGKVSRTVSAQRAGEAAAAADLANARLSQQALLAQTYFQLRTSDALQKLLDETVQSYRQSLQLTQNQYAQGVAARADV
IQAQTQLQSAQAAAIDNGVARAQYEHAIATLIGEPASTFSLPPMPLTAEPPITPVDVPSTLLERRPDIAAAERRAAAANE
QIGVAISAFFPTLTLSASGGFESSVWSQLFTLPARFWTVGPQLAATLFDAGLRAAQTQAARATYDQDVAAYRLAVLSAFQ
DVEDNLASQRILAQEIDVQRQAVESAEHALAIVTNQYKAGTVAYLNVLTAQTTAFTARQKLATITGQRMVSSVGLVKALG
GGWNVSDIARETGDMAAPAAVPASGAAAASAVSAVSAAPAPGTLARQ
>Mature_526_residues
PYAPLPRALRPLSAAVAVATAVLLAGCAVGPDYHRPDTSIPAAFKEAPAGWKVAQPADRADRGPWWTVYDDPQLNALIDK
LNASNQTIAQSAAAYRQARALVSEARAAYFPTVGLSASGSRARTPRSSFSSGTSSSFGSSTSGSINNSYSVGLDASWEPD
LWGKVSRTVSAQRAGEAAAAADLANARLSQQALLAQTYFQLRTSDALQKLLDETVQSYRQSLQLTQNQYAQGVAARADVI
QAQTQLQSAQAAAIDNGVARAQYEHAIATLIGEPASTFSLPPMPLTAEPPITPVDVPSTLLERRPDIAAAERRAAAANEQ
IGVAISAFFPTLTLSASGGFESSVWSQLFTLPARFWTVGPQLAATLFDAGLRAAQTQAARATYDQDVAAYRLAVLSAFQD
VEDNLASQRILAQEIDVQRQAVESAEHALAIVTNQYKAGTVAYLNVLTAQTTAFTARQKLATITGQRMVSSVGLVKALGG
GWNVSDIARETGDMAAPAAVPASGAAAASAVSAVSAAPAPGTLARQ

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=480, Percent_Identity=28.125, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI2367348, Length=488, Percent_Identity=26.0245901639344, Blast_Score=122, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55087; Mature: 54956

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYAPLPRALRPLSAAVAVATAVLLAGCAVGPDYHRPDTSIPAAFKEAPAGWKVAQPADR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
ADRGPWWTVYDDPQLNALIDKLNASNQTIAQSAAAYRQARALVSEARAAYFPTVGLSASG
CCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SRARTPRSSFSSGTSSSFGSSTSGSINNSYSVGLDASWEPDLWGKVSRTVSAQRAGEAAA
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHH
AADLANARLSQQALLAQTYFQLRTSDALQKLLDETVQSYRQSLQLTQNQYAQGVAARADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAQTQLQSAQAAAIDNGVARAQYEHAIATLIGEPASTFSLPPMPLTAEPPITPVDVPST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LLERRPDIAAAERRAAAANEQIGVAISAFFPTLTLSASGGFESSVWSQLFTLPARFWTVG
HHHCCCCHHHHHHHHHHCCCCCCEEHEEHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCC
PQLAATLFDAGLRAAQTQAARATYDQDVAAYRLAVLSAFQDVEDNLASQRILAQEIDVQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVESAEHALAIVTNQYKAGTVAYLNVLTAQTTAFTARQKLATITGQRMVSSVGLVKALG
HHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGWNVSDIARETGDMAAPAAVPASGAAAASAVSAVSAAPAPGTLARQ
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PYAPLPRALRPLSAAVAVATAVLLAGCAVGPDYHRPDTSIPAAFKEAPAGWKVAQPADR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
ADRGPWWTVYDDPQLNALIDKLNASNQTIAQSAAAYRQARALVSEARAAYFPTVGLSASG
CCCCCEEEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SRARTPRSSFSSGTSSSFGSSTSGSINNSYSVGLDASWEPDLWGKVSRTVSAQRAGEAAA
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCHHHH
AADLANARLSQQALLAQTYFQLRTSDALQKLLDETVQSYRQSLQLTQNQYAQGVAARADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAQTQLQSAQAAAIDNGVARAQYEHAIATLIGEPASTFSLPPMPLTAEPPITPVDVPST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
LLERRPDIAAAERRAAAANEQIGVAISAFFPTLTLSASGGFESSVWSQLFTLPARFWTVG
HHHCCCCHHHHHHHHHHCCCCCCEEHEEHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCC
PQLAATLFDAGLRAAQTQAARATYDQDVAAYRLAVLSAFQDVEDNLASQRILAQEIDVQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVESAEHALAIVTNQYKAGTVAYLNVLTAQTTAFTARQKLATITGQRMVSSVGLVKALG
HHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGWNVSDIARETGDMAAPAAVPASGAAAASAVSAVSAAPAPGTLARQ
CCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]