Click here to switch to the map view.

The map label for this gene is uxaC

Identifier: 161511193

GI number: 161511193

Start: 1016996

End: 1018402

Strand: Reverse

Name: uxaC

Synonym: BT_0823

Alternate gene names: 161511193

Gene position: 1018402-1016996 (Counterclockwise)

Preceding gene: 29346236

Following gene: 29346230

Centisome position: 16.27

GC content: 45.84

Gene sequence:

>1407_bases
ATGAAGAACTTCATGGATGAAAACTTCTTGCTGCAGACAGAAACTGCACAAAAGTTGTATCACGAGCATGCGGCTAAAAT
GCCGATTATTGACTACCACTGTCATCTAATCCCCCAAATGGTAGCTGACGACTACAAGTTTAAATCACTGACTGAAATCT
GGTTGGGTGGCGACCATTACAAATGGCGTGCAATGCGTACAAATGGCGTAGACGAACGCTATTGTACAGGAAAAGATACC
ACAGACTGGGAAAAGTTCGAAAAATGGGCTGAAACCGTTCCTTATACCTTCCGCAACCCGTTGTATCATTGGACACACCT
GGAATTGAAGACTGCTTTCGGCATCGACAAGATTTTAAGCCCCAAGACTGCACGCGAGATTTACGACGAGTGTAACGAGA
AGTTGGCTCAGCCAGAATACTCAGCTCGCGGAATGATGCGTCGTTACCACGTGGAAGTAGTATGTACTACGGACGATCCG
ATTGATTCTCTGGAATATCATATCCAGACACGCGAAAGCGGTTTTGAAATCAAAATGTTGCCTACCTGGCGCCCGGACAA
GGCAATGGCAGTAGAAGTTCCTGCCGACTTCCGCGCTTATGTAGAAAAACTGTCTGCAGTAAGCGGCGTGACAATCTCCA
ATTTCGACGATATGATTGCGGCTCTCCGCAAACGTCATGACTTCTTCGCCGAACAGGGCTGCCGCTTGTCCGACCACGGT
ATCGAAGAGTTCTATGCAGAAGATTACACCGACGCAGAAATCAAAGCTATATTTAATAAGGTATATGGCGGAGCTGAATT
GACTAAAGAAGAAATTCTGAAATTCAAGTCTGCTATGTTGGTAATCTTCGGAGAAATGGACTGGGAAAAAGGATGGACTC
AGCAGTTCCACTACGGTGCTATCCGTAACAACAATACGAAGATGTTCAAATTGTTAGGACCCGATACAGGCTTCGACTCT
ATCGGCGAATTTACAACAGCCAAGGCAATGTCTAAATTCCTCGACCGCCTGAACGTTAACGGCAAGTTGACCAAGACAAT
CCTTTATAACCTGAATCCTTGCGCCAATGAAGTGATTGCCACTATGCTGGGCAACTTCCAGGATGGCTCGATAGCCGGCA
AGATTCAGTTCGGTTCCGGATGGTGGTTCCTCGACCAGAAAGATGGTATGGAAAAACAAATGAACGCGTTGTCAGTACTT
GGACTTTTGAGCCGTTTCGTAGGTATGCTGACAGACTCCCGTTCATTCCTTTCCTATCCACGCCACGAATACTTCCGCCG
TACATTATGTAATTTGGTAGGACGTGATGTGGAGAACGGAGAAATTCCGGTATCTGAAATGGATCGCGTAAATCAGATGA
TCGAAGACATCAGCTACAACAATGCCAAGAACTTCTTCAAATTCTAA

Upstream 100 bases:

>100_bases
AAAACTAAAACAAAGATTTACACCTATTAGCTTTAAAATCAATACTATATAGGTATAAATGCAGAAAGTAATAATTTTAT
ATACTAAAAACACAGTAACA

Downstream 100 bases:

>100_bases
AACAAGAATTACTAAATAGTAATACCGCTGTCGGGGCACGATGCTCCACAGCGGTATTTTTTTTTAAAACTAACGTTCCT
CTCCTTGTAGTTTCATATAC

Product: glucuronate isomerase

Products: NA

Alternate protein names: Glucuronate isomerase; Uronic isomerase

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHYKWRAMRTNGVDERYCTGKDT
TDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILSPKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDP
IDSLEYHIQTRESGFEIKMLPTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG
IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGAIRNNNTKMFKLLGPDTGFDS
IGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIATMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVL
GLLSRFVGMLTDSRSFLSYPRHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF

Sequences:

>Translated_468_residues
MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHYKWRAMRTNGVDERYCTGKDT
TDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILSPKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDP
IDSLEYHIQTRESGFEIKMLPTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG
IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGAIRNNNTKMFKLLGPDTGFDS
IGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIATMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVL
GLLSRFVGMLTDSRSFLSYPRHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF
>Mature_468_residues
MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHYKWRAMRTNGVDERYCTGKDT
TDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILSPKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDP
IDSLEYHIQTRESGFEIKMLPTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG
IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGAIRNNNTKMFKLLGPDTGFDS
IGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIATMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVL
GLLSRFVGMLTDSRSFLSYPRHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1904

COG function: function code G; Glucuronate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uronate isomerase family

Homologues:

Organism=Escherichia coli, GI2367192, Length=468, Percent_Identity=56.6239316239316, Blast_Score=547, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXAC_BACTN (Q8A9J2)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_809736.2
- ProteinModelPortal:   Q8A9J2
- SMR:   Q8A9J2
- GeneID:   1074225
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_0823
- NMPDR:   fig|226186.1.peg.823
- HOGENOM:   HBG297087
- OMA:   AWAKTVP
- PhylomeDB:   Q8A9J2
- ProtClustDB:   PRK02925
- BioCyc:   BTHE226186:BT_0823-MONOMER
- BRENDA:   5.3.1.12
- HAMAP:   MF_00675
- InterPro:   IPR003766
- InterPro:   IPR023177
- Gene3D:   G3DSA:1.10.2020.10

Pfam domain/function: PF02614 UxaC

EC number: =5.3.1.12

Molecular weight: Translated: 54317; Mature: 54317

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHY
CCCCCCCCCEEECHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCE
KWRAMRTNGVDERYCTGKDTTDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILS
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCEEEEEEEHHHHCHHHHCC
PKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDPIDSLEYHIQTRESGFEIKML
CHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEEEEECCCCCHHHHHEEEEECCCCCEEEEE
PTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGA
HHHHHHCCCCCHHHHHHHHHHHCCHHCCHHHHHHHHHCEEEEEECCCCCCCCCHHHCCCE
IRNNNTKMFKLLGPDTGFDSIGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIA
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
TMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVLGLLSRFVGMLTDSRSFLSYP
HHHCCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
RHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCC
>Mature Secondary Structure
MKNFMDENFLLQTETAQKLYHEHAAKMPIIDYHCHLIPQMVADDYKFKSLTEIWLGGDHY
CCCCCCCCCEEECHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCE
KWRAMRTNGVDERYCTGKDTTDWEKFEKWAETVPYTFRNPLYHWTHLELKTAFGIDKILS
EEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCEEEEEEEHHHHCHHHHCC
PKTAREIYDECNEKLAQPEYSARGMMRRYHVEVVCTTDDPIDSLEYHIQTRESGFEIKML
CHHHHHHHHHHHHHHCCCCHHHHHHHEEEEEEEEECCCCCHHHHHEEEEECCCCCEEEEE
PTWRPDKAMAVEVPADFRAYVEKLSAVSGVTISNFDDMIAALRKRHDFFAEQGCRLSDHG
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCC
IEEFYAEDYTDAEIKAIFNKVYGGAELTKEEILKFKSAMLVIFGEMDWEKGWTQQFHYGA
HHHHHHCCCCCHHHHHHHHHHHCCHHCCHHHHHHHHHCEEEEEECCCCCCCCCHHHCCCE
IRNNNTKMFKLLGPDTGFDSIGEFTTAKAMSKFLDRLNVNGKLTKTILYNLNPCANEVIA
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHH
TMLGNFQDGSIAGKIQFGSGWWFLDQKDGMEKQMNALSVLGLLSRFVGMLTDSRSFLSYP
HHHCCCCCCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCC
RHEYFRRTLCNLVGRDVENGEIPVSEMDRVNQMIEDISYNNAKNFFKF
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12663928