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The map label for this gene is hemE [H]

Identifier: 161510048

GI number: 161510048

Start: 1965865

End: 1966902

Strand: Reverse

Name: hemE [H]

Synonym: USA300HOU_1825

Alternate gene names: 161510048

Gene position: 1966902-1965865 (Counterclockwise)

Preceding gene: 161510049

Following gene: 161510047

Centisome position: 68.46

GC content: 34.87

Gene sequence:

>1038_bases
ATGGTGCATAATAAAAACAATACAATTTTAAAAATGATCAAAGGTGAAGAAACATCACATACACCTGTTTGGTTTATGCG
ACAAGCTGGCCGTTCGCAACCAGAATATCGAAAATTGAAAGAAAAATATTCACTATTCGATATTACACATCAGCCGGAGT
TGTGCGCTTATGTAACACATTTACCAGTTGATAATTATCATACAGATGCAGCAATTTTATACAAAGATATTATGACACCA
TTAAAGCCAATTGGTGTCGATGTAGAAATTAAATCGGGTATTGGTCCAGTGATTCATAATCCAATCAAAACAATTCAAGA
TGTTGAGAAACTTTCTCAAATAGACCCCGAACGAGATGTACCATATGTATTAGATACAATTAAACTTTTAACAGAAGAAA
AGTTAAATGTGCCGCTAATAGGATTTACTGGGGCACCATTTACATTAGCGTCATATATGATTGAAGGCGGACCATCGAAA
AATTACAATTTTACAAAAGCGATGATGTATAGAGATGAAGCAACATGGTTTGCTTTAATGAATCATTTAGTTGATGTATC
TGTTAAATATGTAACAGCTCAAGTCGAAGCAGGTGCCGAATTGATTCAAATTTTCGATTCATGGGTAGGTGCATTAAATG
TCGAGGATTACAGACGTTACATTAAACCACATATGATTCGATTAATCAGTGAGGTTAAAGGAAAACATGATGTGCCGGTA
ATTTTATTCGGTGTAGGTGCCAGTCATTTAATCAATGAATGGAATGATTTACCGATTGATGTATTAGGCCTAGATTGGAG
AACGTCTATTAATCAGGCTCAACAATTAGGCGTTACTAAAACATTACAAGGGAATTTAGATCCATCAATTTTATTAGCAC
CATGGAATGTCATTGAAGAGAGATTGAAACCAATATTAGATCAAGGTATGGAGAACGGTAAACACATCTTTAATTTAGGA
CACGGTGTATTCCCAGAAGTGCAACCAGAGACGTTACGTAAAGTAAGCGAATTCGTACACACATATACACAAAGATAA

Upstream 100 bases:

>100_bases
ATGATTAAATGTCAGTTTTATGACATTTATTTATTGAAAATACGAACGAATGAGCGATATGATAATATAGATAAGAATGA
TTTTAATTTAGGAGGCCTTT

Downstream 100 bases:

>100_bases
TCATAGTTTTACATTGAAGCACATGAAAGATAATTCATTTAAAGGAAGGTATTATCAATGACTAAAAAAATGGGATTATT
AGTTATGGCTTATGGCACAC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKGKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR

Sequences:

>Translated_345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKGKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR
>Mature_345_residues
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMYRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKGKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVQPETLRKVSEFVHTYTQR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=36.3636363636364, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=38.1766381766382, Blast_Score=240, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=31.3390313390313, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=35.4651162790698, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=35.1744186046512, Blast_Score=212, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39281; Mature: 39281

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKGKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVHNKNNTILKMIKGEETSHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMYRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKGKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVQPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA