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The map label for this gene is fhs [H]

Identifier: 161509948

GI number: 161509948

Start: 1847789

End: 1849489

Strand: Reverse

Name: fhs [H]

Synonym: USA300HOU_1721

Alternate gene names: 161509948

Gene position: 1849489-1847789 (Counterclockwise)

Preceding gene: 161509949

Following gene: 161509947

Centisome position: 64.38

GC content: 36.27

Gene sequence:

>1701_bases
ATGCATAAATTAAACAAAAAGGGGCGAAAAAAGTTGACTCATTTATCAGATTTAGATATTGCGAATCAATCAACACTACA
ACCAATTAAGGATATTGCTGCATCAGTAGGTATTTCAGAGGATGCATTAGAACCTTATGGTCATTACAAAGCTAAAATCG
ACATTAATAAAATTACGCCAAGAGAAAACAAAGGGAAAGTTGTTTTAGTAACTGCGATGAGCCCAACACCAGCTGGTGAA
GGTAAATCAACGGTTACAGTTGGTTTAGCTGATGCATTCCATGAGTTAAATAAAAACGTTATGGTTGCATTAAGAGAGCC
TGCTTTAGGACCAACATTTGGTATCAAAGGTGGTGCGACTGGTGGTGGTTATGCGCAAGTCTTACCTATGGAAGATATCA
ACTTACATTTCAACGGAGATTTCCATGCGATTACAACTGCAAATAATGCATTGTCTGCGTTTATCGATAATCATATTCAC
CAAGGTAACGAATTAGGAATCGATCAAAGACGTATTGAGTGGAAACGTGTATTAGATATGAATGATCGTGCACTTAGACA
TGTAAACGTTGGGTTAGGTGGACCTACAAATGGTGTACCACGTGAAGATGGCTTTAATATTACAGTAGCGTCTGAAATTA
TGGCGATTTTATGTTTAAGTAGAAGTATTAAAGACTTAAAAGATAAAATTAGTCGTATTACTATTGGTTACACTAGAGAT
CGCAAGCCAGTTACAGTTGCAGATTTAAAAGTGGAAGGTGCACTTGCAATGATTTTAAAAGATGCAATAAAACCAAACTT
AGTACAATCAATTGAAGGGACACCTGCATTAGTTCATGGTGGACCATTTGCGAATATCGCACACGGTTGTAACTCAATTT
TAGCAACTGAAACAGCACGTGATTTAGCTGATATCGTTGTAACGGAAGCTGGATTTGGTTCAGACTTAGGCGCTGAAAAA
TTCATGGACATTAAAGTGCGTGAAGCAGGATTTGATCCGGCAGCTGTCGTTGTTGTTGCGACAATTCGTGCGTTAAAAAT
GCATGGTGGTGTAGCGAAAGATAATTTAAAAGAAGAAAATGTAGAAGCAGTAAAAGCAGGAATTGTTAATTTAGAGCGTC
ATGTTAATAATATTAAAAAATTCGGTGTAGAACCGGTTGTTGCAATTAATGCATTTATACATGATACCGATGCAGAAGTA
GAATATGTAAAATCTTGGGCTAAAGAAAATAACGTACGAATTGCCTTAACTGAAGTTTGGAAAAAAGGTGGTAAAGGTGG
CGTTGACTTAGCAAATGAAGTATTAGAAGTCATTGATCAACCTAATTCATTTAAACCTTTATATGAATTAGAATTACCAT
TAGAGCAAAAGATTGAAAAGATTGTGACTGAAATCTATGGCGGTTCAAAAGTAACGTTTAGCAGTAAAGCGCAAAAACAA
TTAAAACAATTTAAAGAAAATGGTTGGGATAATTACCCAGTATGTATGGCGAAAACACAATATTCATTCTCAGATGATCA
AACGTTGTTAGGTGCACCATCAGGATTTGAAATTACAATTCGTGAATTAGAAGCGAAAACAGGTGCAGGATTTATCGTAG
CGTTGACAGGTGCAATCATGACTATGCCTGGTTTACCTAAAAAACCAGCAGCATTAAACATGGATGTTACTGATGATGGT
CATGCAATTGGGTTATTCTAA

Upstream 100 bases:

>100_bases
AAAATGAAAGCGCTAACCCGATTTAGTCGACAAGTTTTTAACAGTTCGTTATTATATGAATGTAAGTAAAAATTTCTTAG
CTACAACTTACATATTATAA

Downstream 100 bases:

>100_bases
TAAATCATGTCAATTGTTTAATAAAGATAAGTAAATAGTTTAATAGACCGGACTGTTGGAGATGCATTATTTCAGCAGTT
CGGTTTTTTGCTGTGCTAAA

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MHKLNKKGRKKLTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGE
GKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIH
QGNELGIDQRRIEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRD
RKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEK
FMDIKVREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEV
EYVKSWAKENNVRIALTEVWKKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQ
LKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDG
HAIGLF

Sequences:

>Translated_566_residues
MHKLNKKGRKKLTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGE
GKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIH
QGNELGIDQRRIEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRD
RKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEK
FMDIKVREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEV
EYVKSWAKENNVRIALTEVWKKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQ
LKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDG
HAIGLF
>Mature_566_residues
MHKLNKKGRKKLTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITPRENKGKVVLVTAMSPTPAGE
GKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGATGGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIH
QGNELGIDQRRIEWKRVLDMNDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRD
RKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETARDLADIVVTEAGFGSDLGAEK
FMDIKVREAGFDPAAVVVVATIRALKMHGGVAKDNLKEENVEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEV
EYVKSWAKENNVRIALTEVWKKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQ
LKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIMTMPGLPKKPAALNMDVTDDG
HAIGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=619, Percent_Identity=40.5492730210016, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=41.747572815534, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI310124614, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568737, Length=612, Percent_Identity=42.9738562091503, Blast_Score=443, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17568739, Length=612, Percent_Identity=42.9738562091503, Blast_Score=443, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.3137876386688, Blast_Score=451, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=41.85303514377, Blast_Score=442, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=43.6187399030695, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=43.6187399030695, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=43.6187399030695, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=43.6187399030695, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 61216; Mature: 61216

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKLNKKGRKKLTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITP
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCC
RENKGKVVLVTAMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGAT
CCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
GGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDM
CCCCEEEEEECCCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRD
CCCEEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
RKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETAR
CCCEEEEEEEECHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
DLADIVVTEAGFGSDLGAEKFMDIKVREAGFDPAAVVVVATIRALKMHGGVAKDNLKEEN
HHHHHHEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
VEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVW
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHH
KKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQ
HCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHH
LKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIM
HHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHH
TMPGLPKKPAALNMDVTDDGHAIGLF
HCCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MHKLNKKGRKKLTHLSDLDIANQSTLQPIKDIAASVGISEDALEPYGHYKAKIDINKITP
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCC
RENKGKVVLVTAMSPTPAGEGKSTVTVGLADAFHELNKNVMVALREPALGPTFGIKGGAT
CCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCC
GGGYAQVLPMEDINLHFNGDFHAITTANNALSAFIDNHIHQGNELGIDQRRIEWKRVLDM
CCCCEEEEEECCCEEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
NDRALRHVNVGLGGPTNGVPREDGFNITVASEIMAILCLSRSIKDLKDKISRITIGYTRD
CCCEEEEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
RKPVTVADLKVEGALAMILKDAIKPNLVQSIEGTPALVHGGPFANIAHGCNSILATETAR
CCCEEEEEEEECHHHHHHHHHHCCCHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
DLADIVVTEAGFGSDLGAEKFMDIKVREAGFDPAAVVVVATIRALKMHGGVAKDNLKEEN
HHHHHHEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
VEAVKAGIVNLERHVNNIKKFGVEPVVAINAFIHDTDAEVEYVKSWAKENNVRIALTEVW
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHH
KKGGKGGVDLANEVLEVIDQPNSFKPLYELELPLEQKIEKIVTEIYGGSKVTFSSKAQKQ
HCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEECHHHHHH
LKQFKENGWDNYPVCMAKTQYSFSDDQTLLGAPSGFEITIRELEAKTGAGFIVALTGAIM
HHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEHHHHH
TMPGLPKKPAALNMDVTDDGHAIGLF
HCCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA