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The map label for this gene is relA2 [H]

Identifier: 161509859

GI number: 161509859

Start: 1741536

End: 1743746

Strand: Reverse

Name: relA2 [H]

Synonym: USA300HOU_1632

Alternate gene names: 161509859

Gene position: 1743746-1741536 (Counterclockwise)

Preceding gene: 161509860

Following gene: 161509858

Centisome position: 60.7

GC content: 34.55

Gene sequence:

>2211_bases
ATGAATGGGGTGTATCATATAATGAACAACGAATATCCATATAGTGCAGACGAAGTTCTTCACAAAGCAAAATCATATTT
GTCAGCAGATGAATATGAGTATGTTTTAAAAAGCTATCATATTGCTTATGAAGCACATAAAGGTCAGTTCCGAAAAAACG
GATTACCATACATTATGCATCCTATACAAGTTGCAGGTATTTTAACAGAAATGCGATTAGACGGACCGACGATTGTCGCA
GGTTTTTTGCATGATGTAATTGAAGATACACCGTATACATTTGAAGATGTAAAAGAAATGTTCAATGAAGAAGTTGCTCG
AATTGTTGATGGTGTGACGAAGCTTAAAAAAGTAAAATACCGCTCAAAAGAAGAACAACAAGCTGAAAATCATCGCAAGT
TATTTATTGCGATTGCCAAAGATGTACGCGTAATTTTGGTGAAATTAGCAGACAGATTACATAATATGCGTACCTTGAAA
GCCATGCCGCGCGAAAAACAAATTAGAATTTCTCGAGAAACATTAGAAATTTATGCACCATTAGCACATCGTCTTGGTAT
TAATACAATCAAATGGGAACTAGAAGATACGGCTCTTCGTTATATTGATAATGTGCAATATTTTAGAATAGTCAATTTAA
TGAAGAAGAAACGTAGTGAACGTGAAGCGTATATCGAAACGGCTATTGATAGAATACGTACTGAAATGGACCGAATGAAT
ATCGAAGGCGATATAAATGGTAGACCTAAACATATTTACAGTATTTATCGGAAAATGATGAAGCAGAAAAAACAATTTGA
TCAAATTTTTGATTTGTTGGCGATACGTGTTATTGTCAATTCTATTAATGATTGTTATGCGATACTTGGGTTGGTGCATA
CGTTATGGAAACCGATGCCAGGACGTTTTAAAGATTATATTGCAATGCCTAAACAAAATTTGTATCAGTCATTGCATACT
ACAGTAGTAGGCCCAAATGGAGACCCGCTCGAAATCCAAATACGAACGTTTGATATGCACGAAATTGCTGAGCATGGTGT
TGCAGCACACTGGGCTTACAAAGAAGGTAAAAAAGTAAGTGAAAAAGATCAAACTTATCAAAATAAGTTAAATTGGTTAA
AAGAATTAGCTGAAGCGGATCATACATCGTCTGACGCTCAAGAATTTATGGAAACCTTAAAATATGACTTACAGAGTGAC
AAAGTATACGCATTTACCCCAGCGAGTGATGTTATTGAGTTGCCATATGGTGCTGTGCCGATTGATTTTGCTTATGCGAT
TCACAGTGAAGTAGGTAATAAGATGATTGGTGCCAAGGTGAATGGCAAAATTGTACCAATTGACTATATTTTACAAACAG
GCGATATTGTTGAAATACGTACTAGTAAACATTCATATGGACCAAGTCGTGATTGGTTGAAAATTGTTAAATCGTCTAGT
GCCAAAGGTAAAATTAAAAGTTTCTTCAAAAAACAAGATCGTTCATCTAATATTGAAAAAGGCCGAATGATGGTTGAAGC
TGAAATAAAAGAGCAAGGATTTAGAGTCGAAGATATTTTGACAGAGAAAAATATTCAGGTTGTTAATGAAAAATATAACT
TTGCAAATGAAGATGATTTATTCGCAGCTGTAGGATTTGGCGGCGTGACATCCTTACAGATTGTTAATAAATTAACTGAA
AGACAACGTATTTTAGATAAACAACGTGCTTTAAATGAAGCACAAGAAGTTACGAAATCATTGCCTATTAAAGACAACAT
CATTACTGATAGTGGTGTCTATGTAGAAGGTTTAGAAAATGTACTTATCAAGTTGTCAAAATGTTGTAATCCTATACCAG
GTGATGATATTGTAGGTTATATCACCAAAGGTCACGGTATTAAAGTACATCGCACTGATTGCCCAAATATTAAGAACGAA
ACTGAACGACTAATTAATGTTGAATGGGTAAAATCAAAAGACGCAACTCAAAAATATCAGGTTGATTTAGAGGTAACTGC
GTATGACCGAAATGGCTTGTTGAATGAAGTACTACAAGCTGTTAGCTCGACAGCCGGCAATTTAATTAAAGTTTCAGGAC
GTTCAGATATTGATAAAAATGCAATAATAAATATTAGTGTCATGGTGAAAAACGTGAATGATGTTTATCGTGTGGTAGAA
AAGATCAAACAACTTGGTGATGTTTATACAGTAACAAGAGTTTGGAACTAG

Upstream 100 bases:

>100_bases
GACAGGATAAATATTTATCGTCGACGGACGTATGATTGGTGTGGGACAAATACTATTCAACAAGAGTACCTAAATCATTG
TTTAAGGCGAAGTAATAAAT

Downstream 100 bases:

>100_bases
AGGTGCAAAATATGAAAGTAGTTGTACAAAGAGTTAAAGAAGCATCGGTGACGAATGATACATTAAATAATCAAATCAAA
AAAGGATATTGTTTATTAGT

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 736; Mature: 736

Protein sequence:

>736_residues
MNGVYHIMNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVA
GFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLK
AMPREKQIRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMN
IEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHT
TVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSD
KVYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSS
AKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTE
RQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNE
TERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVE
KIKQLGDVYTVTRVWN

Sequences:

>Translated_736_residues
MNGVYHIMNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVA
GFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLK
AMPREKQIRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMN
IEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHT
TVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSD
KVYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSS
AKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTE
RQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNE
TERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVE
KIKQLGDVYTVTRVWN
>Mature_736_residues
MNGVYHIMNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMHPIQVAGILTEMRLDGPTIVA
GFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKYRSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLK
AMPREKQIRISRETLEIYAPLAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMN
IEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMPGRFKDYIAMPKQNLYQSLHT
TVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVSEKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSD
KVYAFTPASDVIELPYGAVPIDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSS
AKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDLFAAVGFGGVTSLQIVNKLTE
RQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLENVLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNE
TERLINVEWVKSKDATQKYQVDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVE
KIKQLGDVYTVTRVWN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=143, Percent_Identity=35.6643356643357, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1790082, Length=716, Percent_Identity=39.5251396648045, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1789147, Length=713, Percent_Identity=37.5876577840112, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=38.3458646616541, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650996, Length=119, Percent_Identity=36.9747899159664, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84510; Mature: 84510

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGVYHIMNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMH
CCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEH
PIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKY
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAP
CCHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHH
LAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMN
HHHHCCCCEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVS
CHHHHHHHCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCC
EKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCC
IDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSS
HHHHHHHHHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCC
AKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDL
CCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHCCCHHEEEHHCCCCCCCCC
FAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLEN
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHH
VLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQ
HHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEE
VDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVE
EEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHH
KIKQLGDVYTVTRVWN
HHHHHCCEEEEEEECC
>Mature Secondary Structure
MNGVYHIMNNEYPYSADEVLHKAKSYLSADEYEYVLKSYHIAYEAHKGQFRKNGLPYIMH
CCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCHHHCCCCEEEH
PIQVAGILTEMRLDGPTIVAGFLHDVIEDTPYTFEDVKEMFNEEVARIVDGVTKLKKVKY
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSKEEQQAENHRKLFIAIAKDVRVILVKLADRLHNMRTLKAMPREKQIRISRETLEIYAP
CCHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEHHHHHHHHHH
LAHRLGINTIKWELEDTALRYIDNVQYFRIVNLMKKKRSEREAYIETAIDRIRTEMDRMN
HHHHCCCCEEEEEHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IEGDINGRPKHIYSIYRKMMKQKKQFDQIFDLLAIRVIVNSINDCYAILGLVHTLWKPMP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GRFKDYIAMPKQNLYQSLHTTVVGPNGDPLEIQIRTFDMHEIAEHGVAAHWAYKEGKKVS
CHHHHHHHCCHHHHHHHHHHEEECCCCCEEEEEEEECCHHHHHHCCCEEEEEHHCCCCCC
EKDQTYQNKLNWLKELAEADHTSSDAQEFMETLKYDLQSDKVYAFTPASDVIELPYGAVP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCC
IDFAYAIHSEVGNKMIGAKVNGKIVPIDYILQTGDIVEIRTSKHSYGPSRDWLKIVKSSS
HHHHHHHHHHHCCCEECEECCCEEEEHHHEECCCCEEEEECCCCCCCCCHHHHHHHHCCC
AKGKIKSFFKKQDRSSNIEKGRMMVEAEIKEQGFRVEDILTEKNIQVVNEKYNFANEDDL
CCHHHHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCHHHHHHCCCHHEEEHHCCCCCCCCC
FAAVGFGGVTSLQIVNKLTERQRILDKQRALNEAQEVTKSLPIKDNIITDSGVYVEGLEN
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHH
VLIKLSKCCNPIPGDDIVGYITKGHGIKVHRTDCPNIKNETERLINVEWVKSKDATQKYQ
HHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCEEE
VDLEVTAYDRNGLLNEVLQAVSSTAGNLIKVSGRSDIDKNAIINISVMVKNVNDVYRVVE
EEEEEEEECCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHHHHHH
KIKQLGDVYTVTRVWN
HHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]