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The map label for this gene is comEB [H]

Identifier: 161509817

GI number: 161509817

Start: 1701026

End: 1701496

Strand: Reverse

Name: comEB [H]

Synonym: USA300HOU_1590

Alternate gene names: 161509817

Gene position: 1701496-1701026 (Counterclockwise)

Preceding gene: 161509818

Following gene: 161509816

Centisome position: 59.23

GC content: 33.33

Gene sequence:

>471_bases
GTGAACATCTTGGAAAGAATCAAATGGGAAGAATATTTTATGGCACAAAGTCATTTGCTAGCATTACGTTCAACTTGTCA
AAGATTATCTGTAGGTGCAACGATTGTTAAGGATAATCGTATTATTGCTGGTGGTTATAATGGCTCTGTAGCTGGCGAGG
TGCATTGTATAGATGAAGGATGTTTAATTGAAGATGGACATTGTATCAGAACGATACATGCAGAAATGAATGCTTTATTA
CAATGTGCAAAACAAGGTGTATCTACTGAAGGTGCAACAATCTATGTTACTCATTTTCCATGCCTAAATTGTACAAAGTC
AATTATTCAAGCAGGTATAAAGCGTATCTACTATGCAGAAGATTATCATAACCATGAATATGCAACTAAATTACTCAAAC
AATCTGGTATTGAATTTAAAAAAATTCCATTTTCACCAGAATATGTTGCTAAATATCTGACTAAAGGTTAA

Upstream 100 bases:

>100_bases
TCTTATTTCACGACATAATGGATTATTTTAATTGCAAATTTTATTTTTTGTGATTAATCTTATATTATTAGAAAATGTTA
CTAAATTTTAAGTATGGAAG

Downstream 100 bases:

>100_bases
TGTTTTGCTGTTTGTCGCGTTATCAATGATTGTAGGAGTGCTTTGGAATTCTAGCAAAGTGCTCTCTACATTTCTTTTCA
TTTTACTTTTGTATATTACT

Product: competence protein ComEB

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MNILERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEGCLIEDGHCIRTIHAEMNALL
QCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAEDYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG

Sequences:

>Translated_156_residues
MNILERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEGCLIEDGHCIRTIHAEMNALL
QCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAEDYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG
>Mature_156_residues
MNILERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEGCLIEDGHCIRTIHAEMNALL
QCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAEDYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=150, Percent_Identity=38, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI61742821, Length=148, Percent_Identity=37.1621621621622, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17557019, Length=150, Percent_Identity=30, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321938, Length=153, Percent_Identity=37.9084967320261, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24667298, Length=158, Percent_Identity=36.7088607594937, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24667302, Length=158, Percent_Identity=36.7088607594937, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 17516; Mature: 17516

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCCCCCCEEEEECCC
CLIEDGHCIRTIHAEMNALLQCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAE
CEEECCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHC
DYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG
CCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCC
>Mature Secondary Structure
MNILERIKWEEYFMAQSHLLALRSTCQRLSVGATIVKDNRIIAGGYNGSVAGEVHCIDEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEEECCCCCCCCCEEEEECCC
CLIEDGHCIRTIHAEMNALLQCAKQGVSTEGATIYVTHFPCLNCTKSIIQAGIKRIYYAE
CEEECCCEEHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHC
DYHNHEYATKLLKQSGIEFKKIPFSPEYVAKYLTKG
CCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]