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The map label for this gene is gcvPA [H]

Identifier: 161509764

GI number: 161509764

Start: 1650838

End: 1652193

Strand: Reverse

Name: gcvPA [H]

Synonym: USA300HOU_1537

Alternate gene names: 161509764

Gene position: 1652193-1650838 (Counterclockwise)

Preceding gene: 161509765

Following gene: 161509763

Centisome position: 57.51

GC content: 34.29

Gene sequence:

>1356_bases
GTGTGCATTGTGAGTCATCGTTATATACCTTTAACTGAAAAAGACAAGCAAGAAATGTTACAAACAATTGGTGCAAAATC
TATAGGAGAATTATTCGGTGATGTACCAAGTGACATTTTATTAAATAGAGATTTAAATATTGCTGAAGGCGAAGCGGAAA
CAACGTTACTTAGAAGATTAAATCGCATTGCAAGCAAGAATATCACTAAAGAAACGCATACATCATTTTTGGGTGCTGGT
GTTTATGATCATTACGCGCCATCAGTTGTGGATGCTATGATTTCAAGATCAGAATTTTACACAGCATATACGCCATATCA
ACCGGAAATTTCTCAAGGTGAATTACAAGCCATTTTTGAGTTCCAAACTTTAATTTGTGAATTAACAGATATGGATGTAG
CAAATTCTTCTATGTATGATGGGATGACTAGCTTTGCTGAAGCATGTATCTTAGCATTTAGTCAAACAAAGAAAAATAAA
ATTGTAGTCTCAAAAGGTTTACATTATCAAGCATTACAAGTACTTCATACTTATGCTAAGACGCGTAAGGAATTCGAAGT
AGTGGAAATCGATTTAGATGGCACTGTTACAGATTTGAAAAAATTAGAAGCAGCAGTGGATGATGAAACAGCAGCTGTTG
CAGTACAATATCCAAACTTTTACGGTTCAATTGAAGATCTTGAAAAGATTCATAGCTTTATTGAAGATAAAAAAGCATTA
TTTATCGTATATGCAAATCCATTAGCATTGGGATTACTTACACCTCCAGGTTCATTTGGTGCAGATATTGTTGTAGGTGA
TACTCAGCCATTCGGAATTCCTGCTCAATTCGGTGGGCCACATTGTGGATATTTTGCAACGACGAAAAAGTTAATGCGTA
AAGTGCCAGGTAGATTAGTCGGTCAAACACAAGATGATGAAGGTAATCGTGGCTTTGTATTAACATTACAAGCACGTGAA
CAACATATTCGACGCGATAAAGCGACATCTAATATTTGTTCTAACCAAGCATTAAATGCTTTAGCGTCATCAATTGCAAT
GTCAGCACTTGGTAAACAAGGTATCTATGATATTGCAGTTCAAAATATAGAACATGCTAACTATGCTAAACAACAATTTA
TTAAAAAAGGTTTTGAAGTATTAGATGGTACATCTTTCAATGAGTTTGTAGTCAAATTTGACAAACCAATTCAACAAGTT
AACGAGGAATTAGTGAAGTACAATATTATCGGTGGTTTTGATTTAGGTGTTGTTTCAGACGACTTTAAAAATCACATGTT
AATAGCTGTAACTGAATTAAGAACAAAAGATGAAATCGATACATTTGTAGAAAAGGCTGGTGAGTTAAATGACTAG

Upstream 100 bases:

>100_bases
GAGTTTGAAATGGGTAGAGAGTTGCTTGTTCAAGTTCGTAAGCGTCAATTAAAAGCGAAAATTGTTAAGAAAAATCAAAT
TGATAAATAATTAAAAAGGG

Downstream 100 bases:

>100_bases
TAAATCAAGTCCATTAATTTTTGAAAGATCTCGTGAAGGCAGATATGCATATTCATTACCAAAAAGTGATATTAAAACAA
ATTCTGTTGAGTCATTGTTA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAG
VYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNK
IVVSKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIHSFIEDKKAL
FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQARE
QHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQV
NEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND

Sequences:

>Translated_451_residues
MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAG
VYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNK
IVVSKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIHSFIEDKKAL
FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQARE
QHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQV
NEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND
>Mature_451_residues
MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAG
VYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNK
IVVSKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIHSFIEDKKAL
FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQARE
QHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQV
NEELVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=362, Percent_Identity=39.7790055248619, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1789269, Length=392, Percent_Identity=35.7142857142857, Blast_Score=205, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17535605, Length=394, Percent_Identity=37.5634517766497, Blast_Score=236, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323843, Length=462, Percent_Identity=35.4978354978355, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24645648, Length=392, Percent_Identity=38.7755102040816, Blast_Score=258, Evalue=5e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 50032; Mature: 50032

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRL
CEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHHHHHH
NRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFE
HHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHH
FQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
TRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIHSFIEDKKAL
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEE
FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLV
EEEEECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHC
GQTQDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAV
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSD
HHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DFKNHMLIAVTELRTKDEIDTFVEKAGELND
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MCIVSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRL
CEEECCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHHHHHH
NRIASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFE
HHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHH
FQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
TRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLEKIHSFIEDKKAL
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEE
FIVYANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLV
EEEEECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHC
GQTQDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAV
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSD
HHCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCC
DFKNHMLIAVTELRTKDEIDTFVEKAGELND
CCCCCEEEEEECCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA