Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 161508491

GI number: 161508491

Start: 268730

End: 269923

Strand: Reverse

Name: fadA [H]

Synonym: USA300HOU_0240

Alternate gene names: 161508491

Gene position: 269923-268730 (Counterclockwise)

Preceding gene: 161508492

Following gene: 161508490

Centisome position: 9.4

GC content: 43.22

Gene sequence:

>1194_bases
ATGATAACCATGCAAGAAGCATACATTGTAGCTTATGGGCGTTCAGCCGCAGCGAAAGCAAAGCAAGGCGCATTATTCCA
CGAAAGACCTGATGATGTCGCAGCCAAAGTATTACAAGGCGTATTGAAACGTATTGACGGAAAATTCAATAAGAATATGA
TTGAAGATGTCATTGTTGGTACGGCTTTTCCAGAAGGATTACAAGGCCAAAACATTGCACGAACGATTGCATTGCGTGCG
GGATTATCTGACACGGTACCGGGTCAAACAGTGAATCGCTACTGCTCATCAGGATTACAAACCATCGCGATTGCAGCCAA
TCAAATTATGGCTGGTCAAGGAGATATACTTGTAGCTGGTGGCGTTGAATTGATGAGTGCCGTACCAATGGGTGGCAACG
AGCCCACAAACAATCCAACCTTACAATATGATGATATAGGTGCGTCATATCCTATGGGTTTAACTGCTGAAAATGTAGCA
TCCCAATTTGACGTATCACGTGAAGATCAAGATGCTTATGCTGTCAGAAGTCATCAACGTGCCTATGACGCACAACGTGA
TGGTCGGTTCAAAGATGAAATTATTCCAATACAAGTAAACTCAGTTGAATATACAAACGCAGGACCAAAAGTACACACAA
ATATCTTTGACCAAGATGAATTTATACGCCCTGACACCACGATGGAGGCATTAGCCAAATTACGTACAGTATTTAAAGCT
GACGGCACTGTGACTGCAGGAACATCTGCCCCACTTTCTGATGGTGCAGGATTTGTAGTTTTAATGTCTGGAGATAAAGT
GAAAGAACTCGGCGTGACACCTATTGCACGATTCGTTGGTTTTAAGGCAGTAGGCGTTGACCCGAAAATTATGGGTATTG
GGCCTGCATATGCGATTCCTGAAGTATTGTCACTCAGCAATCTATCTGTTGAAGACATTGATTTGATCGAATTGAACGAA
GCATTTGCTTCTCAAACGATTGCATCTATTAAAGAAGTAGGTCTAGATATATCACGTACGAATGTGAATGGTGGCGCTAT
TGCTTTAGGTCATCCATTAGGTGCTACAGGCGCAATGTTAACCGCGCGTTTACTTAATGAAATGGGTAGACGTCCCGATA
GCCGTTACGGCATGGTTACGATGTGTATTGGTGTCGGCATGGGTGCAGCTGCTATATTTGAATATGTGCGTTAG

Upstream 100 bases:

>100_bases
TTATTGACTTACTAAAATCTAAAAAATCATATGAAAGAATTGCACATATGTTAAAAACTGGTAAGCCATTACGTAATTAA
AAGATAGTCATTAAGAGAGG

Downstream 100 bases:

>100_bases
AATGGTTGATTTTGGATGAAGCGGATTCGTTTTGTTATTGAATGAAGTAGGCTGAAGTTGAAGCCAGTTGAAGTTGAAGC
GGGTTGAAGCAATTTCGTTT

Product: acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MITMQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRA
GLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVA
SQFDVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKA
DGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNE
AFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Sequences:

>Translated_397_residues
MITMQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRA
GLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVA
SQFDVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKA
DGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNE
AFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
>Mature_397_residues
MITMQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVGTAFPEGLQGQNIARTIALRA
GLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAGGVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVA
SQFDVSREDQDAYAVRSHQRAYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKA
DGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIPEVLSLSNLSVEDIDLIELNE
AFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAMLTARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=391, Percent_Identity=43.9897698209719, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI167614485, Length=360, Percent_Identity=40.8333333333333, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI148539872, Length=387, Percent_Identity=39.5348837209302, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4557237, Length=402, Percent_Identity=34.5771144278607, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4504327, Length=412, Percent_Identity=33.9805825242718, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI194353979, Length=240, Percent_Identity=35.8333333333333, Blast_Score=125, Evalue=6e-29,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=42.3173803526448, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1787663, Length=411, Percent_Identity=41.8491484184915, Blast_Score=277, Evalue=8e-76,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=40.0990099009901, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI87082165, Length=355, Percent_Identity=40.2816901408451, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=32.7669902912621, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI133906874, Length=357, Percent_Identity=40.3361344537815, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=31, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17535921, Length=354, Percent_Identity=34.7457627118644, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17551802, Length=394, Percent_Identity=28.9340101522843, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535917, Length=321, Percent_Identity=27.4143302180685, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322031, Length=405, Percent_Identity=40.2469135802469, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6325229, Length=412, Percent_Identity=31.3106796116505, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=39.8514851485149, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17648125, Length=356, Percent_Identity=41.5730337078652, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI24640423, Length=356, Percent_Identity=35.6741573033708, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=412, Percent_Identity=33.7378640776699, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42151; Mature: 42151

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVG
CCEEECEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TAFPEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEEC
GVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQR
CHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
AYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKA
HHHHHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
DGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIP
CCCEECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHH
EVLSLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAML
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHH
TARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC
>Mature Secondary Structure
MITMQEAYIVAYGRSAAAKAKQGALFHERPDDVAAKVLQGVLKRIDGKFNKNMIEDVIVG
CCEEECEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TAFPEGLQGQNIARTIALRAGLSDTVPGQTVNRYCSSGLQTIAIAANQIMAGQGDILVAG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHEEEHHHHHHCCCCCCEEEEC
GVELMSAVPMGGNEPTNNPTLQYDDIGASYPMGLTAENVASQFDVSREDQDAYAVRSHQR
CHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
AYDAQRDGRFKDEIIPIQVNSVEYTNAGPKVHTNIFDQDEFIRPDTTMEALAKLRTVFKA
HHHHHHCCCCCCCEEEEEECCEEECCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
DGTVTAGTSAPLSDGAGFVVLMSGDKVKELGVTPIARFVGFKAVGVDPKIMGIGPAYAIP
CCCEECCCCCCCCCCCCEEEEECCCCHHHCCCHHHHHHHCCEEECCCCEEEECCCHHHHH
EVLSLSNLSVEDIDLIELNEAFASQTIASIKEVGLDISRTNVNGGAIALGHPLGATGAML
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCCCHHHHH
TARLLNEMGRRPDSRYGMVTMCIGVGMGAAAIFEYVR
HHHHHHHHCCCCCCCCCHHHEEHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]