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The map label for this gene is ispH

Identifier: 161486655

GI number: 161486655

Start: 689355

End: 690305

Strand: Direct

Name: ispH

Synonym: VV0690

Alternate gene names: 161486655

Gene position: 689355-690305 (Clockwise)

Preceding gene: 37678873

Following gene: 37678878

Centisome position: 20.55

GC content: 49.95

Gene sequence:

>951_bases
ATGAAAATCTTGTTAGCGAACCCACGTGGATTCTGTGCGGGTGTCGACCGTGCCATCAGTATTGTTGAGCGTGCACTGGA
GCTGTATCAACCGCCTATCTACGTACGCCATGAAGTGGTGCACAACCGTTTTGTGGTGGAAGGCTTAAAGCAGCGCGGCG
CGATCTTTGTCGAAGAGCTGCATGAAGTGCCAGACGACAATATTGTTATTTTCTCTGCTCATGGCGTGTCTCAAGCGGTG
CGTCAGGAAGCCAAAGAGCGTGCGCTAACTGTGTTTGATGCGACATGCCCATTGGTGACGAAAGTGCATATGGAAGTGGC
GAGAGCCAGCCGTAAGCATATGGAAGTGGTGCTGATCGGTCATGCGGGCCACCCAGAGGTAGAAGGTACCATGGGTCAAT
ATGCCAGCTTGCAGGGTGGCATGTACCTCGTCGAAAAACCGGAAGATGTACTTGGCTTGAAAGCCATTGTTAAAGATCCG
AGCAACTTGCACTACGTAAGCCAAACGACCTTATCGGTGGATGAAACCGCGGACGTGATTGATGAGTTGCGTCGAGTTTT
CCCAGAGATCCAAGGCCCACGCAAAGACGATATCTGCTATGCGACACAAAACCGCCAAGATGCGGTGCGTGAATTGGCGA
AAGATGTCGACGTGGTAGTGGTAGTGGGTTCAAAGAACTCCTCAAACTCGACCCGACTAAAAGAGTTGGCGGAAAAACTA
GGCACACCTGCTTACTTAACAGATTGTCCGCAAGACATTGAGCCACAATGGTTTGATGGCAAAGTCAAAGTGGGCGTAAC
GGCAGGGGCTTCTGCACCAGAAGAACTGGTCAATCAAATCCTAACTCGCATTAAAGAGTTGGGTGCTCAATCGGTTGAAG
AAGTGCTAGGCCGTGAAGAGAACATGTTCTTTGAAGTGCCTAAAGAGCTGCAAATTAAGCAGATTGACTAA

Upstream 100 bases:

>100_bases
TGGATTTCAATCATCCACTTGCAGGCCAAGATGTGACTTTTGAAGTTGAAATTTTGTCAGTAGAATAGCCAGCGAAAAGA
AAACTACCATGAGCAATGAA

Downstream 100 bases:

>100_bases
CGAGTCATCCTGATTTGAATACCTAAGGTCTACAGGCCTTAGTAATGGCGATCTCAGTATCGCCATTTTTAATGGCTGAG
TCCCAACATCTCTTTGAGCA

Product: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEELHEVPDDNIVIFSAHGVSQAV
RQEAKERALTVFDATCPLVTKVHMEVARASRKHMEVVLIGHAGHPEVEGTMGQYASLQGGMYLVEKPEDVLGLKAIVKDP
SNLHYVSQTTLSVDETADVIDELRRVFPEIQGPRKDDICYATQNRQDAVRELAKDVDVVVVVGSKNSSNSTRLKELAEKL
GTPAYLTDCPQDIEPQWFDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEVLGREENMFFEVPKELQIKQID

Sequences:

>Translated_316_residues
MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEELHEVPDDNIVIFSAHGVSQAV
RQEAKERALTVFDATCPLVTKVHMEVARASRKHMEVVLIGHAGHPEVEGTMGQYASLQGGMYLVEKPEDVLGLKAIVKDP
SNLHYVSQTTLSVDETADVIDELRRVFPEIQGPRKDDICYATQNRQDAVRELAKDVDVVVVVGSKNSSNSTRLKELAEKL
GTPAYLTDCPQDIEPQWFDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEVLGREENMFFEVPKELQIKQID
>Mature_316_residues
MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEELHEVPDDNIVIFSAHGVSQAV
RQEAKERALTVFDATCPLVTKVHMEVARASRKHMEVVLIGHAGHPEVEGTMGQYASLQGGMYLVEKPEDVLGLKAIVKDP
SNLHYVSQTTLSVDETADVIDELRRVFPEIQGPRKDDICYATQNRQDAVRELAKDVDVVVVVGSKNSSNSTRLKELAEKL
GTPAYLTDCPQDIEPQWFDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEVLGREENMFFEVPKELQIKQID

Specific function: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) [H]

COG id: COG0761

COG function: function code IM; Penicillin tolerance protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispH family [H]

Homologues:

Organism=Escherichia coli, GI1786212, Length=318, Percent_Identity=66.3522012578616, Blast_Score=429, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003451 [H]

Pfam domain/function: PF02401 LYTB [H]

EC number: =1.17.1.2 [H]

Molecular weight: Translated: 35115; Mature: 35115

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEEL
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HEVPDDNIVIFSAHGVSQAVRQEAKERALTVFDATCPLVTKVHMEVARASRKHMEVVLIG
HCCCCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEE
HAGHPEVEGTMGQYASLQGGMYLVEKPEDVLGLKAIVKDPSNLHYVSQTTLSVDETADVI
CCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECEECHHHHHHHH
DELRRVFPEIQGPRKDDICYATQNRQDAVRELAKDVDVVVVVGSKNSSNSTRLKELAEKL
HHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
GTPAYLTDCPQDIEPQWFDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEVLGREE
CCCCEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCC
NMFFEVPKELQIKQID
CEEEECCCCCCEEECC
>Mature Secondary Structure
MKILLANPRGFCAGVDRAISIVERALELYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEEL
CEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HEVPDDNIVIFSAHGVSQAVRQEAKERALTVFDATCPLVTKVHMEVARASRKHMEVVLIG
HCCCCCCEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEE
HAGHPEVEGTMGQYASLQGGMYLVEKPEDVLGLKAIVKDPSNLHYVSQTTLSVDETADVI
CCCCCCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECEECHHHHHHHH
DELRRVFPEIQGPRKDDICYATQNRQDAVRELAKDVDVVVVVGSKNSSNSTRLKELAEKL
HHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHH
GTPAYLTDCPQDIEPQWFDGKVKVGVTAGASAPEELVNQILTRIKELGAQSVEEVLGREE
CCCCEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHCCCC
NMFFEVPKELQIKQID
CEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]