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The map label for this gene is norM [H]

Identifier: 161486623

GI number: 161486623

Start: 1785190

End: 1786560

Strand: Direct

Name: norM [H]

Synonym: VV1730

Alternate gene names: 161486623

Gene position: 1785190-1786560 (Clockwise)

Preceding gene: 37679912

Following gene: 37679915

Centisome position: 53.22

GC content: 45.81

Gene sequence:

>1371_bases
GTGCATCGCTATAAAAAAGAAGCTTCTAGTTTGATTAAGCTCGCCACACCAGTTTTGATTGCATCTGTTGCTCAAACCGG
TATGGGTTTTGTGGACACCGTGATGGCGGGTGGCGTCAGTGCAACGGACATGGCTGCCGTTTCTGTCGCAGCAAGTATCT
GGCTGCCTTCTATTTTGTTTGGTATTGGGCTATTGATGGCACTGGTCCCTGTTGTCGCTCAGCTCAATGGAGCAGGCAAA
AGAGAGCAAGTCCCTTTTGAAATTCAACAAGGCGCGGTTATGGCCCTATTGATCAGTATCCCGATCATTGGCGTATTGTT
TCAAACTCAGTGGATACTCGGTTACATGAATGTCGATGCGGTAATGGCGACCAAAACCATTGGTTATATACACGCTGTGA
TGTTTGCCGTACCTGCTTTTCTATTGTTTCAAACACTGCGCAGTTTGACTGATGGTTTGTCTTTAACAAAACCTGCCATG
GTGATCGGTTTCATTGGCTTATTATTGAATATTCCACTGAACTGGATGTTCGTTTACGGTAAATTGGGTGCGCCAGCCCT
TGGTGGTGTAGGTTGTGGCGTCGCCACAGCCATAGTGTATTGGATTATGTTTTTGTTGCTACTGCTTTATGTGACAACGT
CACAGAGACTAAGGCAGGTTCAATTGTTTACTACGTTTCATCCACCACAGCTAAATGCGCAAGTTAAGCTATTTAAACTT
GGCTTTCCGGTCGCTGCCGCACTTTTCTTCGAGGTGACTCTGTTTGCGGTCGTCGCTTTGTTGGTTGCGCCATTGGGTTC
TACTGTCGTTGCAGCACACCAAGTTGCCATTAACTTTTCTTCATTGGTGTTCATGTTACCTATGAGTATTGGCGCAGCAA
CCAGTATCCGTGTTGGGCATATGCTTGGTGAAAAATCGACAGAAGGCGCACGCATTGCTTCTCATGTTGGTATCTTAGTT
GGTCTTTCAACTGCAGTGTTTACCGCTTTACTGACGGTTATTCTGAGAGAGCAAATCGCTCTCCTCTATACCGATAACCG
AGTGGTTATCACCTTAGCGATGCAGTTGTTGATCTTTGCCGCTATTTATCAATGTACCGATGCAATACAAGTTATCGCCG
CTGGTGCGCTACGTGGTTATAAAGACATGCGAGCGATCTTTAACCGAACATTTATCGCCTATTGGTTACTTGGTCTACCT
ACTGGTTATGTTCTTGGTCTTACCGATTGGATTGTTGAACCAATGGGTGCACAAGGCTTCTGGATAGGATTCATCGTCGG
CTTATCTTCTGCGGCCGCTATGTTGGGAGTTCGCCTACACTGGCTTCACCGCCAAAATGATGAAATCCAGTTGAATTATG
AAGCGAGATAA

Upstream 100 bases:

>100_bases
CGCCTCATAAACCACTTTTGTGGCCTTTGCCGATCGAAAACATCCCAACGTGCCTCGCACGCTTAGCATATTTATCTTTT
TCTTAAACAATGGAGTTAAC

Downstream 100 bases:

>100_bases
TTACTAGCCCTCGCTTTCAGTCGACAAGATTGAATAAACCAACGAAATAAAGCGCGACTTTTCTATTCTATCGCGCTTTA
TTATCCCAAGATTTTAGACT

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MHRYKKEASSLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASIWLPSILFGIGLLMALVPVVAQLNGAGK
REQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDAVMATKTIGYIHAVMFAVPAFLLFQTLRSLTDGLSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWIMFLLLLLYVTTSQRLRQVQLFTTFHPPQLNAQVKLFKL
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAATSIRVGHMLGEKSTEGARIASHVGILV
GLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFAAIYQCTDAIQVIAAGALRGYKDMRAIFNRTFIAYWLLGLP
TGYVLGLTDWIVEPMGAQGFWIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNYEAR

Sequences:

>Translated_456_residues
MHRYKKEASSLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASIWLPSILFGIGLLMALVPVVAQLNGAGK
REQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDAVMATKTIGYIHAVMFAVPAFLLFQTLRSLTDGLSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWIMFLLLLLYVTTSQRLRQVQLFTTFHPPQLNAQVKLFKL
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAATSIRVGHMLGEKSTEGARIASHVGILV
GLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFAAIYQCTDAIQVIAAGALRGYKDMRAIFNRTFIAYWLLGLP
TGYVLGLTDWIVEPMGAQGFWIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNYEAR
>Mature_456_residues
MHRYKKEASSLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASIWLPSILFGIGLLMALVPVVAQLNGAGK
REQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDAVMATKTIGYIHAVMFAVPAFLLFQTLRSLTDGLSLTKPAM
VIGFIGLLLNIPLNWMFVYGKLGAPALGGVGCGVATAIVYWIMFLLLLLYVTTSQRLRQVQLFTTFHPPQLNAQVKLFKL
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAATSIRVGHMLGEKSTEGARIASHVGILV
GLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFAAIYQCTDAIQVIAAGALRGYKDMRAIFNRTFIAYWLLGLP
TGYVLGLTDWIVEPMGAQGFWIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNYEAR

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=446, Percent_Identity=26.2331838565022, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI153792564, Length=444, Percent_Identity=24.7747747747748, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI38261960, Length=480, Percent_Identity=23.75, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI48994890, Length=457, Percent_Identity=55.1422319474836, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI226510954, Length=445, Percent_Identity=24.0449438202247, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321821, Length=382, Percent_Identity=24.0837696335079, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320545, Length=423, Percent_Identity=24.113475177305, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49149; Mature: 49149

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRYKKEASSLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASIWLPSILF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GIGLLMALVPVVAQLNGAGKREQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VMATKTIGYIHAVMFAVPAFLLFQTLRSLTDGLSLTKPAMVIGFIGLLLNIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
KLGAPALGGVGCGVATAIVYWIMFLLLLLYVTTSQRLRQVQLFTTFHPPQLNAQVKLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEE
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAATSIRVGH
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
MLGEKSTEGARIASHVGILVGLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFA
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHH
AIYQCTDAIQVIAAGALRGYKDMRAIFNRTFIAYWLLGLPTGYVLGLTDWIVEPMGAQGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCH
WIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNYEAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MHRYKKEASSLIKLATPVLIASVAQTGMGFVDTVMAGGVSATDMAAVSVAASIWLPSILF
CCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
GIGLLMALVPVVAQLNGAGKREQVPFEIQQGAVMALLISIPIIGVLFQTQWILGYMNVDA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
VMATKTIGYIHAVMFAVPAFLLFQTLRSLTDGLSLTKPAMVIGFIGLLLNIPLNWMFVYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
KLGAPALGGVGCGVATAIVYWIMFLLLLLYVTTSQRLRQVQLFTTFHPPQLNAQVKLFKL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEEEEEEE
GFPVAAALFFEVTLFAVVALLVAPLGSTVVAAHQVAINFSSLVFMLPMSIGAATSIRVGH
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
MLGEKSTEGARIASHVGILVGLSTAVFTALLTVILREQIALLYTDNRVVITLAMQLLIFA
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHH
AIYQCTDAIQVIAAGALRGYKDMRAIFNRTFIAYWLLGLPTGYVLGLTDWIVEPMGAQGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCH
WIGFIVGLSSAAAMLGVRLHWLHRQNDEIQLNYEAR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA