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The map label for this gene is ahpC [C]

Identifier: 161485727

GI number: 161485727

Start: 1656438

End: 1657115

Strand: Direct

Name: ahpC [C]

Synonym: CT1747

Alternate gene names: 161485727

Gene position: 1656438-1657115 (Clockwise)

Preceding gene: 21674561

Following gene: 21674565

Centisome position: 76.87

GC content: 54.28

Gene sequence:

>678_bases
ATGTCACAACAAGTTGATGACGACCTCTATTATGACATCTCAATGCCGCTGCTCGGGGACGATTTTCCGGAACTGAAGGT
TCAAACAACGCATGGCCCGATGAACATTCCGGGAGACCTGAAAGGCTCGTGGTTCGTGCTTTTCAGCCACCCGGCTGACT
TTACGCCGGTCTGCACGACAGAGTTTGTCGCATTCCAGCAGCGGGTAGAGGCGTTTGAAAAGATCGGCTGCAAGCTCATC
GGCATGAGCGTCGATCAGGTCTTCTCGCACATCAAGTGGGTCGAGTGGATCAAGGAGAATCTCGATGTTGACATCACCTT
CCCGATCGTGGCGGCCAACGACCGTATCGCGAACAAACTTGGGATGTTGCATCCCGGCAAAGGCACGAACACCGTCCGCG
CAGTTTTCGTAGGCGACCCGAACGGCAAGGTACGCCTCGTGCTTTACTATCCACAGGAGATCGGACGGAACATGGACGAG
ATTCTGCGCGCCGTCAAGGTCTTGCAGATTTCCGACAGCAACAAGGTTGCCATGCCTGCTGACTGGCCAAACAACTTGCT
CATCAAGGATCACGTGATCATTCCGCCAGCAAACAACGTCGAAGACGCCAAAAAGCGCAAGGAGCAGCAATACGACTGCT
ACGACTGGTGGTTCTGCCACAAGCCGCTCGACAAGTAA

Upstream 100 bases:

>100_bases
TCAAGGCCGTTTCGGGCTTAATGAGGTACTTCCAAAAAGGAGGTACTTCCAAAAAGCAAAATCAAACGCAACAGAACAAA
AGTACAAGGAGCGCTAAACC

Downstream 100 bases:

>100_bases
GCCGGTAAGTCGAAGTGATCGAAAACGAAACAGCCCCGGAACTGTCACAAAACCAGTTCCAGGGCTGATCTGTTTTTGCT
CCGGTTATAAAAAAGGTCAA

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSQQVDDDLYYDISMPLLGDDFPELKVQTTHGPMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQQRVEAFEKIGCKLI
GMSVDQVFSHIKWVEWIKENLDVDITFPIVAANDRIANKLGMLHPGKGTNTVRAVFVGDPNGKVRLVLYYPQEIGRNMDE
ILRAVKVLQISDSNKVAMPADWPNNLLIKDHVIIPPANNVEDAKKRKEQQYDCYDWWFCHKPLDK

Sequences:

>Translated_225_residues
MSQQVDDDLYYDISMPLLGDDFPELKVQTTHGPMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQQRVEAFEKIGCKLI
GMSVDQVFSHIKWVEWIKENLDVDITFPIVAANDRIANKLGMLHPGKGTNTVRAVFVGDPNGKVRLVLYYPQEIGRNMDE
ILRAVKVLQISDSNKVAMPADWPNNLLIKDHVIIPPANNVEDAKKRKEQQYDCYDWWFCHKPLDK
>Mature_224_residues
SQQVDDDLYYDISMPLLGDDFPELKVQTTHGPMNIPGDLKGSWFVLFSHPADFTPVCTTEFVAFQQRVEAFEKIGCKLIG
MSVDQVFSHIKWVEWIKENLDVDITFPIVAANDRIANKLGMLHPGKGTNTVRAVFVGDPNGKVRLVLYYPQEIGRNMDEI
LRAVKVLQISDSNKVAMPADWPNNLLIKDHVIIPPANNVEDAKKRKEQQYDCYDWWFCHKPLDK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=199, Percent_Identity=40.2010050251256, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI32189392, Length=157, Percent_Identity=35.6687898089172, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4505591, Length=157, Percent_Identity=37.5796178343949, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI32455266, Length=157, Percent_Identity=37.5796178343949, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI32455264, Length=157, Percent_Identity=37.5796178343949, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI5802974, Length=154, Percent_Identity=33.7662337662338, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI32483377, Length=154, Percent_Identity=33.7662337662338, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI5453549, Length=164, Percent_Identity=31.0975609756098, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI33188454, Length=58, Percent_Identity=51.7241379310345, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786822, Length=151, Percent_Identity=30.4635761589404, Blast_Score=68, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17554494, Length=146, Percent_Identity=37.6712328767123, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25153706, Length=196, Percent_Identity=33.1632653061224, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193204376, Length=190, Percent_Identity=31.5789473684211, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32565831, Length=186, Percent_Identity=31.7204301075269, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319407, Length=198, Percent_Identity=41.9191919191919, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6323613, Length=155, Percent_Identity=32.258064516129, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320661, Length=155, Percent_Identity=30.9677419354839, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24581278, Length=195, Percent_Identity=39.4871794871795, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17975518, Length=205, Percent_Identity=40.9756097560976, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24652434, Length=205, Percent_Identity=40.9756097560976, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24652436, Length=205, Percent_Identity=40.4878048780488, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17738015, Length=176, Percent_Identity=35.2272727272727, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357347, Length=146, Percent_Identity=34.2465753424658, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24656348, Length=143, Percent_Identity=33.5664335664336, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17864676, Length=143, Percent_Identity=33.5664335664336, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17157991, Length=146, Percent_Identity=32.8767123287671, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24641739, Length=146, Percent_Identity=32.8767123287671, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 25721; Mature: 25590

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQVDDDLYYDISMPLLGDDFPELKVQTTHGPMNIPGDLKGSWFVLFSHPADFTPVCTT
CCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
EFVAFQQRVEAFEKIGCKLIGMSVDQVFSHIKWVEWIKENLDVDITFPIVAANDRIANKL
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
GMLHPGKGTNTVRAVFVGDPNGKVRLVLYYPQEIGRNMDEILRAVKVLQISDSNKVAMPA
CCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHCCCHHHHHHHHHEEEECCCCCEEECC
DWPNNLLIKDHVIIPPANNVEDAKKRKEQQYDCYDWWFCHKPLDK
CCCCCEEEECEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SQQVDDDLYYDISMPLLGDDFPELKVQTTHGPMNIPGDLKGSWFVLFSHPADFTPVCTT
CCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCHHH
EFVAFQQRVEAFEKIGCKLIGMSVDQVFSHIKWVEWIKENLDVDITFPIVAANDRIANKL
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
GMLHPGKGTNTVRAVFVGDPNGKVRLVLYYPQEIGRNMDEILRAVKVLQISDSNKVAMPA
CCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHCCCHHHHHHHHHEEEECCCCCEEECC
DWPNNLLIKDHVIIPPANNVEDAKKRKEQQYDCYDWWFCHKPLDK
CCCCCEEEECEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]