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The map label for this gene is fumC

Identifier: 161485611

GI number: 161485611

Start: 224976

End: 226376

Strand: Reverse

Name: fumC

Synonym: Dde_0240

Alternate gene names: 161485611

Gene position: 226376-224976 (Counterclockwise)

Preceding gene: 78355288

Following gene: 78355284

Centisome position: 6.07

GC content: 60.96

Gene sequence:

>1401_bases
ATGCCCCCAGCCACCCGTACGGAACATGACAGCATGGGCGCAGTGGAAGTGCCCGCCGACCGCTACTGGGGCGCGCAGAC
GCAGCGCTCGCTCAAATATTTCGCCATCGGGCAGGACACCATGCCCGAAGAAATCATCCGCGCTTTCGGGCTGCTGAAAA
AGGCTGCCGCCATTGCCAACCGTGATCTGGGCAGACTGGACCCGGAACTGTGCGGTTTCATATGCGCCGCAGCGGATGAA
GTAGCCGACGGAAAACTTTCCGGTCACTTTCCGCTCAAGGTCTGGCAGACGGGCAGCGGCACGCAGACCAACATGAATGT
GAACGAGGTCATCGCCAACCGTGCCATTGAGCTGAGCGGAGGCATTCCCGGTTCCAAATCTCCCGTGCACCCCAATGATC
ATGTGAACATGTCACAATCATCCAACGACACATTTCCTGCGGCCATGCACATAGCCGCAGCCACAGCCCTTTCCCGCGAA
CTGGTGCCTGCGGTGCGCACGCTGCGCAACGCGCTGGCACAAAAAAGCCACGACTGGCAGTCGGTGGTCAAGCTGGGCCG
CACACATCTGCAGGATGCCGTGCCCATGACGCTGGGGCAGGAATTTTCCGGATACACAGCTCTTCTTGATGACGGACTGG
AAAGAATGGAAGCGGTGATGCCCCATCTGCTGCGGCTGGCGCTGGGCGGCACGGCAGTGGGGACGGGTCTTAACGCTCCG
CGTGGTTTTGCGGGCATGGCTGCCGCGGGTGTTGCGCGCTTCACGGGTCTGCCTTTTGTACCGGCACCCAATTTTTTTGC
CGTGCTTTCAGCCCACGATGCCGTGTGCATGGCCAGCGGAGCGCTGCGCACCCTTGCCGGTTCACTGATGAAAATAGCCA
ACGACATCCGCTGGCTGGCATCGGGGCCGCGTTGCGGCATCGGCGAACTCAGACTGCCCGCCAACGAACCCGGATCGTCC
ATCATGCCCGGCAAGGTCAACCCCACGCAGTGCGAAGCTCTGACCATGGTGGCCGTGCAGGTGATGGGGCTGGACGCCGC
CACCGGCATAGCCGGTTCGCAGGGCAATTTCGAGCTGAACGTCTTCAAGCCGCTGATGATTTTCAATCTGCTGACATCCG
TGCGCCTGCTGACAGACGGCTGCCGTTCATTCACCGCCCATGCAGTGGAAGGCATGCAGCCTGACATGCAGCGTATCAGC
GACCATCTGGGCAGATCGCTCATGCTTGTGACTGCGTTGTCGCCCGTCATCGGCTACGACAATGCCGCCAGAGCGGCGCA
CCACGCACATGCGCGGGGCACAACGCTCAAAGAGGCCTGTCTGGAACTGGAACTTATTTCGGCAGAAGAATTTGACGCTG
CCGTGGACCCCATGGTCATGGCAGTTCCCCATGGCGCATGA

Upstream 100 bases:

>100_bases
CCTTCTGCATAGACACCATGACATGCCGCACGTACCATGTGCAGACGCACCGCCGCAAAAATATTCCCCGCCGCACCAAT
GTCACCATGAAGGAGAAGCC

Downstream 100 bases:

>100_bases
CTGCCTGCGGCTTCAACAGGCCTGCTGCTGTGCCCCCGCGCCACGGCCGGCTGTGTACGGCAGCAGTATGCGGAAGCAGG
CTCCGCCCGATTCCGGAGAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MPPATRTEHDSMGAVEVPADRYWGAQTQRSLKYFAIGQDTMPEEIIRAFGLLKKAAAIANRDLGRLDPELCGFICAAADE
VADGKLSGHFPLKVWQTGSGTQTNMNVNEVIANRAIELSGGIPGSKSPVHPNDHVNMSQSSNDTFPAAMHIAAATALSRE
LVPAVRTLRNALAQKSHDWQSVVKLGRTHLQDAVPMTLGQEFSGYTALLDDGLERMEAVMPHLLRLALGGTAVGTGLNAP
RGFAGMAAAGVARFTGLPFVPAPNFFAVLSAHDAVCMASGALRTLAGSLMKIANDIRWLASGPRCGIGELRLPANEPGSS
IMPGKVNPTQCEALTMVAVQVMGLDAATGIAGSQGNFELNVFKPLMIFNLLTSVRLLTDGCRSFTAHAVEGMQPDMQRIS
DHLGRSLMLVTALSPVIGYDNAARAAHHAHARGTTLKEACLELELISAEEFDAAVDPMVMAVPHGA

Sequences:

>Translated_466_residues
MPPATRTEHDSMGAVEVPADRYWGAQTQRSLKYFAIGQDTMPEEIIRAFGLLKKAAAIANRDLGRLDPELCGFICAAADE
VADGKLSGHFPLKVWQTGSGTQTNMNVNEVIANRAIELSGGIPGSKSPVHPNDHVNMSQSSNDTFPAAMHIAAATALSRE
LVPAVRTLRNALAQKSHDWQSVVKLGRTHLQDAVPMTLGQEFSGYTALLDDGLERMEAVMPHLLRLALGGTAVGTGLNAP
RGFAGMAAAGVARFTGLPFVPAPNFFAVLSAHDAVCMASGALRTLAGSLMKIANDIRWLASGPRCGIGELRLPANEPGSS
IMPGKVNPTQCEALTMVAVQVMGLDAATGIAGSQGNFELNVFKPLMIFNLLTSVRLLTDGCRSFTAHAVEGMQPDMQRIS
DHLGRSLMLVTALSPVIGYDNAARAAHHAHARGTTLKEACLELELISAEEFDAAVDPMVMAVPHGA
>Mature_465_residues
PPATRTEHDSMGAVEVPADRYWGAQTQRSLKYFAIGQDTMPEEIIRAFGLLKKAAAIANRDLGRLDPELCGFICAAADEV
ADGKLSGHFPLKVWQTGSGTQTNMNVNEVIANRAIELSGGIPGSKSPVHPNDHVNMSQSSNDTFPAAMHIAAATALSREL
VPAVRTLRNALAQKSHDWQSVVKLGRTHLQDAVPMTLGQEFSGYTALLDDGLERMEAVMPHLLRLALGGTAVGTGLNAPR
GFAGMAAAGVARFTGLPFVPAPNFFAVLSAHDAVCMASGALRTLAGSLMKIANDIRWLASGPRCGIGELRLPANEPGSSI
MPGKVNPTQCEALTMVAVQVMGLDAATGIAGSQGNFELNVFKPLMIFNLLTSVRLLTDGCRSFTAHAVEGMQPDMQRISD
HLGRSLMLVTALSPVIGYDNAARAAHHAHARGTTLKEACLELELISAEEFDAAVDPMVMAVPHGA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=60.8695652173913, Blast_Score=544, Evalue=1e-155,
Organism=Homo sapiens, GI266458395, Length=88, Percent_Identity=47.7272727272727, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787896, Length=455, Percent_Identity=58.2417582417582, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI87082375, Length=455, Percent_Identity=38.9010989010989, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17553882, Length=460, Percent_Identity=59.5652173913044, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=57.7981651376147, Blast_Score=385, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=59.3548387096774, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.1792656587473, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=58.5683297180043, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=58.5683297180043, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=57.7922077922078, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=51.8279569892473, Blast_Score=474, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49327; Mature: 49196

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPATRTEHDSMGAVEVPADRYWGAQTQRSLKYFAIGQDTMPEEIIRAFGLLKKAAAIAN
CCCCCCCCCCCCCCEECCHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
RDLGRLDPELCGFICAAADEVADGKLSGHFPLKVWQTGSGTQTNMNVNEVIANRAIELSG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCEEECC
GIPGSKSPVHPNDHVNMSQSSNDTFPAAMHIAAATALSRELVPAVRTLRNALAQKSHDWQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
SVVKLGRTHLQDAVPMTLGQEFSGYTALLDDGLERMEAVMPHLLRLALGGTAVGTGLNAP
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
RGFAGMAAAGVARFTGLPFVPAPNFFAVLSAHDAVCMASGALRTLAGSLMKIANDIRWLA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGIGELRLPANEPGSSIMPGKVNPTQCEALTMVAVQVMGLDAATGIAGSQGNFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEE
VFKPLMIFNLLTSVRLLTDGCRSFTAHAVEGMQPDMQRISDHLGRSLMLVTALSPVIGYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
NAARAAHHAHARGTTLKEACLELELISAEEFDAAVDPMVMAVPHGA
CHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHCCEEEECCCCC
>Mature Secondary Structure 
PPATRTEHDSMGAVEVPADRYWGAQTQRSLKYFAIGQDTMPEEIIRAFGLLKKAAAIAN
CCCCCCCCCCCCCEECCHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHC
RDLGRLDPELCGFICAAADEVADGKLSGHFPLKVWQTGSGTQTNMNVNEVIANRAIELSG
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCEEECC
GIPGSKSPVHPNDHVNMSQSSNDTFPAAMHIAAATALSRELVPAVRTLRNALAQKSHDWQ
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
SVVKLGRTHLQDAVPMTLGQEFSGYTALLDDGLERMEAVMPHLLRLALGGTAVGTGLNAP
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
RGFAGMAAAGVARFTGLPFVPAPNFFAVLSAHDAVCMASGALRTLAGSLMKIANDIRWLA
CCCHHHHHHHHHHHCCCCCCCCCCCEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGPRCGIGELRLPANEPGSSIMPGKVNPTQCEALTMVAVQVMGLDAATGIAGSQGNFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCEEEE
VFKPLMIFNLLTSVRLLTDGCRSFTAHAVEGMQPDMQRISDHLGRSLMLVTALSPVIGYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCC
NAARAAHHAHARGTTLKEACLELELISAEEFDAAVDPMVMAVPHGA
CHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]