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The map label for this gene is obgE

Identifier: 161485606

GI number: 161485606

Start: 2696935

End: 2698035

Strand: Reverse

Name: obgE

Synonym: Dde_2690

Alternate gene names: 161485606

Gene position: 2698035-2696935 (Counterclockwise)

Preceding gene: 78357733

Following gene: 78357731

Centisome position: 72.33

GC content: 55.77

Gene sequence:

>1101_bases
ATGCGTTTTGTAGACGAAGCAGTAATCAAAGCTATTTCTGGCAACGGCGGCCATGGCTGTGTTTCTTTCCGCCGCGAAAA
ATTCATTCCCAGAGGCGGACCGGACGGCGGGGACGGCGGAAATGGCGGAAATGTGGTCTTCAAGGCATCCACTCGCCTGC
TCAGCCTGTACGATTTCCGTCTGAAGCGGGTATATCAGGCAGAAAACGGCCGTCCCGGCCAGGGCAGCCAGATGCACGGC
CGCGGCGGCAAGGATCTGGTGGTGGAAATGCCCGTGGGCACGCTGGTTTTCGAGCGCGGTGAAAACGGTGCCGAAAGCCT
TATCGCCGATCTTTCGGAGCCGGACGTTGAAGTCGTCATTGCCCATGGTGGCCGTGGCGGCAAGGGAAATGAACATTTCA
AGTCATCCACCATGCAGGCTCCCCGTTTTTCACAGCCGGGCGAACCGGGCGAAGAAAAATCTCTGAGGCTTGAGCTTAAA
ATTCTGGCGGATGCCGGTCTGCTGGGTCTGCCCAATGCCGGTAAGTCGACTTTCATATCTCAGGTTTCGGCGGCAAAGCC
TAAAATCGCCGCGTACCCTTTCACCACGCTTGTGCCAAATCTGGGCGTGATGATGGATGAATTTGATCCGGACAGACGCA
TGGTCATCGCCGACATTCCGGGCCTGATTGAAGGTGCTCACGAAGGGCAGGGACTGGGGCACCGTTTTCTCAAGCACGTG
GAGCGCACACGTTTTCTGGTACACATTCTGAGCATAGAAGATGTGGACATGGAAAACCCGTGGGCCGGTTTCGACCTGAT
CAACGACGAACTGCAGCGTTTTGACGAAACACTGGGCAGCCGCGAACAGATTCAGGTTGTCAACAAAATAGACCTGCTGC
CTCCTGAAGAGGTTGACGGGCTGCGGGCAAGAGCCGAAGCTGACGGCCGCCGGATTTTCTTCATTTCCGCTCTGGAAGGT
GAAGGACTGGACGCGGTTGTAAGTGAAATGTGGCGAATGCTCGCCGAACTGGACAGGAATGTTCCTCTTGATTCTTCGCG
CCAGATAGAGCCTGAACCCGAAGAGGAATTTGATGTGGAAGTAGTCTGGGTGCGCGAATAG

Upstream 100 bases:

>100_bases
CACGCGGGACGCTTTATGGCATCGTTGGTGTACGGCGGGGCTTTTTTGCTGTCCTTCCGGGCGGCATGTAACGACACTTT
TTTGCAGCAGGCAGATATTT

Downstream 100 bases:

>100_bases
TCTTTTAGCGGAGGCGTCTGAAAGCCATGGACTGGCAGACCGAGCGCGGGCAGGTTCTGGATTCCGCCCGCAGAGTGGTT
ATCAAGGTGGGGAGTGCGGT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MRFVDEAVIKAISGNGGHGCVSFRREKFIPRGGPDGGDGGNGGNVVFKASTRLLSLYDFRLKRVYQAENGRPGQGSQMHG
RGGKDLVVEMPVGTLVFERGENGAESLIADLSEPDVEVVIAHGGRGGKGNEHFKSSTMQAPRFSQPGEPGEEKSLRLELK
ILADAGLLGLPNAGKSTFISQVSAAKPKIAAYPFTTLVPNLGVMMDEFDPDRRMVIADIPGLIEGAHEGQGLGHRFLKHV
ERTRFLVHILSIEDVDMENPWAGFDLINDELQRFDETLGSREQIQVVNKIDLLPPEEVDGLRARAEADGRRIFFISALEG
EGLDAVVSEMWRMLAELDRNVPLDSSRQIEPEPEEEFDVEVVWVRE

Sequences:

>Translated_366_residues
MRFVDEAVIKAISGNGGHGCVSFRREKFIPRGGPDGGDGGNGGNVVFKASTRLLSLYDFRLKRVYQAENGRPGQGSQMHG
RGGKDLVVEMPVGTLVFERGENGAESLIADLSEPDVEVVIAHGGRGGKGNEHFKSSTMQAPRFSQPGEPGEEKSLRLELK
ILADAGLLGLPNAGKSTFISQVSAAKPKIAAYPFTTLVPNLGVMMDEFDPDRRMVIADIPGLIEGAHEGQGLGHRFLKHV
ERTRFLVHILSIEDVDMENPWAGFDLINDELQRFDETLGSREQIQVVNKIDLLPPEEVDGLRARAEADGRRIFFISALEG
EGLDAVVSEMWRMLAELDRNVPLDSSRQIEPEPEEEFDVEVVWVRE
>Mature_366_residues
MRFVDEAVIKAISGNGGHGCVSFRREKFIPRGGPDGGDGGNGGNVVFKASTRLLSLYDFRLKRVYQAENGRPGQGSQMHG
RGGKDLVVEMPVGTLVFERGENGAESLIADLSEPDVEVVIAHGGRGGKGNEHFKSSTMQAPRFSQPGEPGEEKSLRLELK
ILADAGLLGLPNAGKSTFISQVSAAKPKIAAYPFTTLVPNLGVMMDEFDPDRRMVIADIPGLIEGAHEGQGLGHRFLKHV
ERTRFLVHILSIEDVDMENPWAGFDLINDELQRFDETLGSREQIQVVNKIDLLPPEEVDGLRARAEADGRRIFFISALEG
EGLDAVVSEMWRMLAELDRNVPLDSSRQIEPEPEEEFDVEVVWVRE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=328, Percent_Identity=40.8536585365854, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI111955139, Length=296, Percent_Identity=35.472972972973, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI111955063, Length=129, Percent_Identity=43.4108527131783, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI58761500, Length=134, Percent_Identity=33.5820895522388, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789574, Length=366, Percent_Identity=45.0819672131148, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI1787454, Length=132, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=304, Percent_Identity=39.4736842105263, Blast_Score=157, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=322, Percent_Identity=31.6770186335404, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=162, Percent_Identity=32.0987654320988, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=184, Percent_Identity=41.8478260869565, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI20129375, Length=290, Percent_Identity=42.7586206896552, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24585318, Length=340, Percent_Identity=34.1176470588235, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_DESDG (Q30XW0)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389181.2
- HSSP:   Q5SJ29
- STRING:   Q30XW0
- GeneID:   3757713
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2690
- NMPDR:   fig|207559.3.peg.3014
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- ProtClustDB:   PRK12299
- BioCyc:   DDES207559:DDE_2690-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 40224; Mature: 40224

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVDEAVIKAISGNGGHGCVSFRREKFIPRGGPDGGDGGNGGNVVFKASTRLLSLYDFR
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
LKRVYQAENGRPGQGSQMHGRGGKDLVVEMPVGTLVFERGENGAESLIADLSEPDVEVVI
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHCCCCCEEEEE
AHGGRGGKGNEHFKSSTMQAPRFSQPGEPGEEKSLRLELKILADAGLLGLPNAGKSTFIS
EECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCHHHHHH
QVSAAKPKIAAYPFTTLVPNLGVMMDEFDPDRRMVIADIPGLIEGAHEGQGLGHRFLKHV
HHHHCCCCEEECCHHHHHCCCCCEECCCCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHH
ERTRFLVHILSIEDVDMENPWAGFDLINDELQRFDETLGSREQIQVVNKIDLLPPEEVDG
HHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCCCCHHCC
LRARAEADGRRIFFISALEGEGLDAVVSEMWRMLAELDRNVPLDSSRQIEPEPEEEFDVE
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VVWVRE
EEEEEC
>Mature Secondary Structure
MRFVDEAVIKAISGNGGHGCVSFRREKFIPRGGPDGGDGGNGGNVVFKASTRLLSLYDFR
CCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
LKRVYQAENGRPGQGSQMHGRGGKDLVVEMPVGTLVFERGENGAESLIADLSEPDVEVVI
HHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCHHHHHHHCCCCCEEEEE
AHGGRGGKGNEHFKSSTMQAPRFSQPGEPGEEKSLRLELKILADAGLLGLPNAGKSTFIS
EECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEECCCCCHHHHHH
QVSAAKPKIAAYPFTTLVPNLGVMMDEFDPDRRMVIADIPGLIEGAHEGQGLGHRFLKHV
HHHHCCCCEEECCHHHHHCCCCCEECCCCCCCEEEEECCCHHHCCCCCCCCHHHHHHHHH
ERTRFLVHILSIEDVDMENPWAGFDLINDELQRFDETLGSREQIQVVNKIDLLPPEEVDG
HHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEHHHHHCCCCCCHHCC
LRARAEADGRRIFFISALEGEGLDAVVSEMWRMLAELDRNVPLDSSRQIEPEPEEEFDVE
HHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEE
VVWVRE
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA