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The map label for this gene is pyrG [H]

Identifier: 161484706

GI number: 161484706

Start: 1694767

End: 1696380

Strand: Direct

Name: pyrG [H]

Synonym: PF1839

Alternate gene names: 161484706

Gene position: 1694767-1696380 (Clockwise)

Preceding gene: 18978208

Following gene: 18978212

Centisome position: 88.81

GC content: 42.26

Gene sequence:

>1614_bases
ATGACGAAGTACATATTTGTTACTGGAGGAGTTGTGAGTGGGCTTGGAAAGGGAATCACAAGCGCTTCAATAGGGCTTCT
CATGAAAGCTAGAGGCTACAAAACAACCAACATCAAAATTGATCCTTACATCAACTATGATGCTGGAACTATGAACCCCT
ATCAGCACGGAGAAGTCTTCGTTCTTGACGATGGTGGAGAAGTGGATCTTGATTTAGGAAATTATGAAAGATTCTTAGAC
ACAGAATTGACTTTTGACCATAACATAACAACTGGAAAGGTATATTCTACTGTAATAGAAAAGGAGAGAAGAGGAGAATA
TCTCGGAGCCACTGTCCAAGTTATTCCTCACATCACAGATGAAATAAAGAGGAGAATAAGAGAGATAGCTAAGGATTACG
AAGTCGTTGTAGTGGAGATAGGAGGCACCGTGGGAGATATAGAAAGCATGCCTTTCCTCGAGGCAGCGAGACAAATGCAG
CTAGAAGAAGGAAGAGACAACGTGGCATTCGTTCATGTAACATACGTTCCAAAACTCAAGGTAGTTGGAGAACAGAAGAC
AAAGCCAACCCAACACAGCGTCAAAGAGCTCCGCTCCCTGGGAATACAACCAGATGCAATTGTTGCCAGAAGTGAAGATC
CCCTTGAAGAGGCCGCAAGAAAGAAAATAAGCCTATTTACCAACGTTCCAGAGGAAGCCGTTATCAGCGCGTATGACGTT
GAAGATACATATGAAGTTCCCCTCCTACTGGAGAGAGAAGGACTCGGAAAATATCTAACAAAAAGGCTCAAGCTTGAAGA
TAGGGAACCAGACCTAAAAGATTGGGAAAAGATGGTTGCAAAATACAAGGCCCTAACTGAAACTGTTGAGATTGCAATAG
TTGGAAAGTACGTCAAATTGCAAGATTCTTACCTTAGCATTAAAGAAGCATTAAAACATGCCAGCGTTAGTAATGAAGTC
AAGGTAAAGATAAGATGGATTGAGGCCGAGGACGTTGAAACTCATGGAACGAAGCTTCTTGAAGGAGTTGATGGTATTAT
AATCCCAGGAGGATTTGGGGCAAGGGGAGCTGAAGGAAAGATACAGGCAATAAGATATGCAAGAGAAAATGACATCCCCT
TCCTAGGCATATGCTTTGGCTTCCAACTAACAGTTGTTGAGTTTGCAAGAAATGTTTTAGGAATGAAGGGAGCCCATTCA
ACTGAAATAGATCCCCAAACTCCATATCCAGTTGTTGACCTAATGCCAGAGCAGCGAAACCTAGACAGGCTTGGAGGAAC
TATGAGACTTGGAGCTTACCCAGTAAAGATAAAGAAAGGAACCTTAGCATATTCCCTTTACAATAAGGAACTCGTATATG
AGAGACATAGGCACAGGTGGGAGGTCAATCCTAATTACATTGAAGCTCTTGAGAAAGCTGGATTAGTGTTTAGTGGAGTT
GCGGGGGACGATGAAAGAAGAATGGAAATTCTAGAATTGCCAGATAAGAGATACTTCATAGCAACTCAGTTCCACCCAGA
ATTTAAGTCGAGGCCAATGAGACCAGCTCCAGTCTTTCACGGACTCGTTAGAGCAGCAAAAGAATACAAACAGGAGAAAA
ATGTTACTCACTAA

Upstream 100 bases:

>100_bases
AAATTTCCAAAAAGTATCTCAAAAGAGCAGATTAAAAGTTTTATGTGTATAAAATGATTATAAACGAAAGGTTTTAATGC
CCCTATTCAACCTCACAATC

Downstream 100 bases:

>100_bases
TCATGCTAAAGAAAGGATAGCTAAGAGGTTAGCTAAGAAAAGAAAAATTTACAAAATTTACTCTACCTTATTTTCTTTTC
TAAAAAATTCGATTAGGATT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFLD
TELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITDEIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQ
LEEGRDNVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDV
EDTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKLQDSYLSIKEALKHASVSNEV
KVKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGKIQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHS
TEIDPQTPYPVVDLMPEQRNLDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGV
AGDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH

Sequences:

>Translated_537_residues
MTKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFLD
TELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITDEIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQ
LEEGRDNVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDV
EDTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKLQDSYLSIKEALKHASVSNEV
KVKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGKIQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHS
TEIDPQTPYPVVDLMPEQRNLDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGV
AGDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH
>Mature_536_residues
TKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVFVLDDGGEVDLDLGNYERFLDT
ELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITDEIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQL
EEGRDNVAFVHVTYVPKLKVVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDVE
DTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKLQDSYLSIKEALKHASVSNEVK
VKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGKIQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHST
EIDPQTPYPVVDLMPEQRNLDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGVA
GDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=51.4598540145985, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI28559085, Length=550, Percent_Identity=51.2727272727273, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI28559083, Length=550, Percent_Identity=51.2727272727273, Blast_Score=548, Evalue=1e-156,
Organism=Homo sapiens, GI221316689, Length=550, Percent_Identity=51.2727272727273, Blast_Score=548, Evalue=1e-156,
Organism=Escherichia coli, GI1789142, Length=542, Percent_Identity=52.0295202952029, Blast_Score=568, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=601, Percent_Identity=41.5973377703827, Blast_Score=473, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=49.1197183098592, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322563, Length=566, Percent_Identity=46.8197879858657, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=50.5474452554745, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=49.0872210953347, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60609; Mature: 60478

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVF
CCEEEEEECHHHHHHCCCCCHHHHHHEEEECCCEEEEEEECCEEECCCCCCCCCCCCEEE
VLDDGGEVDLDLGNYERFLDTELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITD
EEECCCEEEEECCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQLEEGRDNVAFVHVTYVPKLK
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEE
VVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDV
EECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHEEEECC
EDTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKL
CCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
QDSYLSIKEALKHASVSNEVKVKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGK
CHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCCCCC
IQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHSTEIDPQTPYPVVDLMPEQRN
EEEEEEHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCC
LDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGV
HHHCCCEEEECCEEEEEECCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEC
AGDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH
CCCHHHHHHHEECCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKYIFVTGGVVSGLGKGITSASIGLLMKARGYKTTNIKIDPYINYDAGTMNPYQHGEVF
CEEEEEECHHHHHHCCCCCHHHHHHEEEECCCEEEEEEECCEEECCCCCCCCCCCCEEE
VLDDGGEVDLDLGNYERFLDTELTFDHNITTGKVYSTVIEKERRGEYLGATVQVIPHITD
EEECCCEEEEECCCCHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHEEHHHHHH
EIKRRIREIAKDYEVVVVEIGGTVGDIESMPFLEAARQMQLEEGRDNVAFVHVTYVPKLK
HHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEE
VVGEQKTKPTQHSVKELRSLGIQPDAIVARSEDPLEEAARKKISLFTNVPEEAVISAYDV
EECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCHHHHEEEECC
EDTYEVPLLLEREGLGKYLTKRLKLEDREPDLKDWEKMVAKYKALTETVEIAIVGKYVKL
CCCCCCCEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEEE
QDSYLSIKEALKHASVSNEVKVKIRWIEAEDVETHGTKLLEGVDGIIIPGGFGARGAEGK
CHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCHHHHHHHHCCCCEEECCCCCCCCCCCC
IQAIRYARENDIPFLGICFGFQLTVVEFARNVLGMKGAHSTEIDPQTPYPVVDLMPEQRN
EEEEEEHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCC
LDRLGGTMRLGAYPVKIKKGTLAYSLYNKELVYERHRHRWEVNPNYIEALEKAGLVFSGV
HHHCCCEEEECCEEEEEECCEEEEEECCHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEC
AGDDERRMEILELPDKRYFIATQFHPEFKSRPMRPAPVFHGLVRAAKEYKQEKNVTH
CCCHHHHHHHEECCCCEEEEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]