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The map label for this gene is tmk [H]

Identifier: 161407223

GI number: 161407223

Start: 1456695

End: 1457327

Strand: Direct

Name: tmk [H]

Synonym: Mmcs_1346

Alternate gene names: 161407223

Gene position: 1456695-1457327 (Clockwise)

Preceding gene: 108798312

Following gene: 108798318

Centisome position: 25.53

GC content: 71.41

Gene sequence:

>633_bases
GTGCTCATCGCGATCGAAGGTGTCGACGGCGCAGGCAAGCGCACCCTGACCACCGGCATGCGGGCCGCCTTCGAAGGTGC
CGGGCGGTCGGTCGCGACGCTGGCCTTTCCGCGTTACCACCGGTCGGTCACCGCCGACCTGGCGGCGGAAGCCCTTCACG
GCAGACACGGCGACCTCGCCGAGTCGGTCTATGCGATGGCGGTGTTGTTCGCACTCGACCGTGCCGACGCTCGCGACGAG
ATCGCACACCTCGCCGCCGCCCACGACGTGGTGATCCTGGACCGCTACGTCGCCTCCAACGCCGCCTACAGCGCCGCACG
TCTACACCAGTCCGCCGACGGGGAGGCGGTCGAGTGGGTGAGGTCGCTCGAGTACGACCGACTGGGCCTACCGGCCGCCG
ACTGGCAGATCCTGCTCGACGTGCCGACTGCGCTGGCCGCCGAACGGGCCGAACGCCGCGCCGAACAGGAGGCCGACCGC
GCCCGCGACGCCTACGAGCGTGACGACGGTCTGCAGCGGCGAACCGGCGAGGTGTACCAAGCGCTGGCCGCAACCGACTG
GTGCGGGCGCTGGATCGTGGCCGGACCCGACGTCGACGCGGCGGCGCTGGCCGACGGATTGACCGCTTCCTGA

Upstream 100 bases:

>100_bases
CCGACCAGCCGGGTAAAGCCTATCGGCGTTCGAGGGCGGTCCGATGCACCAGTTTGCGCCCGGGACGGATCCGGCCGCCG
GACGCGGTTACGCTCACCGC

Downstream 100 bases:

>100_bases
GGTCAACCGGAGAAACGCCCTGCGTGGTAGCCGGGTTTTATCGCGATCTGGTGACACCATGGACTCCATGAGGCAAAGGA
TTCTGGTCGTCGATGACGAT

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAESVYAMAVLFALDRADARDE
IAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADR
ARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS

Sequences:

>Translated_210_residues
MLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAESVYAMAVLFALDRADARDE
IAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADR
ARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS
>Mature_210_residues
MLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLAESVYAMAVLFALDRADARDE
IAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWVRSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADR
ARDAYERDDGLQRRTGEVYQALAATDWCGRWIVAGPDVDAAALADGLTAS

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22573; Mature: 22573

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
ESVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADRARDAYERDDGLQRRTGEVYQ
HHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALAATDWCGRWIVAGPDVDAAALADGLTAS
HHHHHHHHCCEEEECCCCCHHHHHCCCCCC
>Mature Secondary Structure
MLIAIEGVDGAGKRTLTTGMRAAFEGAGRSVATLAFPRYHRSVTADLAAEALHGRHGDLA
CEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
ESVYAMAVLFALDRADARDEIAHLAAAHDVVILDRYVASNAAYSAARLHQSADGEAVEWV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RSLEYDRLGLPAADWQILLDVPTALAAERAERRAEQEADRARDAYERDDGLQRRTGEVYQ
HHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALAATDWCGRWIVAGPDVDAAALADGLTAS
HHHHHHHHCCEEEECCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]