Click here to switch to the map view.

The map label for this gene is clcB [H]

Identifier: 161353601

GI number: 161353601

Start: 1567098

End: 1568351

Strand: Reverse

Name: clcB [H]

Synonym: STM1490

Alternate gene names: 161353601

Gene position: 1568351-1567098 (Counterclockwise)

Preceding gene: 16764836

Following gene: 16764831

Centisome position: 32.29

GC content: 58.29

Gene sequence:

>1254_bases
ATGTTTCGTCGCCTGCTGATCGCTACGCTCATCGGTATTCTCGCGGCGCTGGCTGTCGCCGCCTTCCGTCATGCGATGCA
ATTGCTGGAGTGGATTTTCCTGAGTAATGACACCGGCAGTCTGGTGAATGCGGCTGAGGGGCTTTCGCCCTGGCGACGGC
TGATTACGCCGGCGCTTGGCGGCCTGGCCGCTGGTCTGTTGCTGTGGGGGTGGCAAAAAATGAACCAACAGCGCCCCCAT
GCGCCCACTGACTATATGGAAGCATTGCAAACCGACGGGCAATTTGACGTTGGCGCCAGTCTGGTGAAATCGCTGGCCTC
GCTGCTGGTCGTGGTCAGCGGCAGCGCAATTGGTCGCGAAGGCGCAATGATCCTCCTCGCCGCGCTGGCGGCGTCCAGCT
TTGCCCGACGCTTCACGCCGCGTGAGGAATGGAAATTATGGATCGCCAGCGGCGCCGCTGCGGGCATGGCGGGCGCTTAC
CATGCGCCGCTGGCGGGCAGTCTGTTTATCGCGGAGATCCTGTTCGGTACCTTAATGCTGGCTTCCCTCGGCCCGGTTGT
CGTTTCCGCCGTCGTCGCCCTGCTAACCACCCATGTATTAAACGGTAGCGATTCACTACTCTATACCGTACATCTGACCG
TTGATCTCCACGCGCGGGAGTACGTCATGATAGTCAGTACCGGCCTGGTCGCCGGTCTGTGCGGCCCATTGCTGATGTGG
CTGATGACGGCCAGCCATAATAGTTTCTTACGTTTAAAACTGTCCCCGCCCTGGCAACTGGCGTTGGGCGGGCTTATTGT
CGGATTACTGTCGTTACTCACGCCCACGGTATGGGGAAACGGCTATAGCGTCGTACAATCATTTTTGCTCTCCCCGCCGC
TATTCTCGCTGATTGGCGGAATTTTTGTGTGCAAAATCCTGGCGGTGCTCGCCAGCAGCGGGTCTGGCGCGCCGGGCGGC
GTCTTTACGCCAACATTATTTGTCGGATTATCCATTGGAATGTTTCTGGGTCGGATATGGGGATTCTGGCTGCCAGGCTC
GGATGAAATAGCGATTTTATTGGGGCTGGCGGGTATGGCGACGCTACTGGCGGCGACAACCCATGCGCCGATAATGTCCA
CCCTGATGATTTGTGAAATGACCGGCGAGTATCAGTTACTCCCCGGTCTGCTGATTGCCTGTGTAGTCGCGTCAGTGCTC
TCGCGAACGTTACGCCATGATTCTATCTACCGCCAGCACGCTGCCGAGCATTGA

Upstream 100 bases:

>100_bases
CTTTTGCGTCTGACGCCATTTCCCCGCAGAATAGGCTATCCTGAAACTCCCTGTTTACCCGCTCATGCATCGTTTACACG
CTTACCCGGATCTGCGCGCG

Downstream 100 bases:

>100_bases
CAAACGAATATACTGCCCCAGCTCACGCTGCTCGGCGCGCGGCAGGTACGGTAGCTCGCCAATCAGCGGCGCTGGCAGTT
TTTTCCCAAGCACATCAATA

Product: voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAAGLLLWGWQKMNQQRPH
APTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAY
HAPLAGSLFIAEILFGTLMLASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMW
LMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGGIFVCKILAVLASSGSGAPGG
VFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVL
SRTLRHDSIYRQHAAEH

Sequences:

>Translated_417_residues
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAAGLLLWGWQKMNQQRPH
APTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAY
HAPLAGSLFIAEILFGTLMLASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMW
LMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGGIFVCKILAVLASSGSGAPGG
VFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVL
SRTLRHDSIYRQHAAEH
>Mature_417_residues
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALGGLAAGLLLWGWQKMNQQRPH
APTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGREGAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAY
HAPLAGSLFIAEILFGTLMLASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMW
LMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGGIFVCKILAVLASSGSGAPGG
VFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVL
SRTLRHDSIYRQHAAEH

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=417, Percent_Identity=78.8968824940048, Blast_Score=606, Evalue=1e-175,
Organism=Escherichia coli, GI1786350, Length=258, Percent_Identity=27.1317829457364, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 44120; Mature: 44120

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GLAAGLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGRE
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEILFGTLML
HHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMW
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHH
LMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGG
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IFVCKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLSRTLRHDSIYRQHAAEH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFRRLLIATLIGILAALAVAAFRHAMQLLEWIFLSNDTGSLVNAAEGLSPWRRLITPALG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
GLAAGLLLWGWQKMNQQRPHAPTDYMEALQTDGQFDVGASLVKSLASLLVVVSGSAIGRE
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
GAMILLAALAASSFARRFTPREEWKLWIASGAAAGMAGAYHAPLAGSLFIAEILFGTLML
HHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
ASLGPVVVSAVVALLTTHVLNGSDSLLYTVHLTVDLHAREYVMIVSTGLVAGLCGPLLMW
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHHHHHHHH
LMTASHNSFLRLKLSPPWQLALGGLIVGLLSLLTPTVWGNGYSVVQSFLLSPPLFSLIGG
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHH
IFVCKILAVLASSGSGAPGGVFTPTLFVGLSIGMFLGRIWGFWLPGSDEIAILLGLAGMA
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
TLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVVASVLSRTLRHDSIYRQHAAEH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA