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The map label for this gene is nrdZ [H]

Identifier: 161347547

GI number: 161347547

Start: 2485638

End: 2487869

Strand: Direct

Name: nrdZ [H]

Synonym: SYN_01226

Alternate gene names: 161347547

Gene position: 2485638-2487869 (Clockwise)

Preceding gene: 85860298

Following gene: 85860305

Centisome position: 78.18

GC content: 53.67

Gene sequence:

>2232_bases
ATGAAAAAAAGAACTTCCAGCATAGATATTTCTTCACTGACCGATAATGCGATCAAGGTTCTGGGAAGACGTTATCTGAA
GCGAGACAGGGATGGAAACGCTTTGGAAACACCCTCCCAGATGTTCAAACGGGTTGCCGATACGATTGCCGCCGCGGACC
GGATATTCAATGATCAGGCAGATACCGCCGGACTATCTGACCAGTTTTACCGGATGATGACCGCCCTGGAATTTCTTCCC
AATTCTCCGACCCTGATGAATGCGGGAAGGGAACTGGGGCAGCTATCCGCCTGTTTTGTTCTTCCCGTCGGCGATTCCAT
GGAGGACATATTTGACGCCGTCAAATTCACTGCCCTGATTCACAAGTCCGGCGGCGGAACCGGTTTCTCCTTTTCCCGCC
TTCGCCCCGCCAATGACGTGGTTTTAACGACGACGGGAATCTCCAGCGGTCCAATCTCCTTCATGCGGGTTTTTGACGTC
GCAACGGAAACCATAAAGCAGGGCGGCACACGCCGGGGCGCCAACATGGGCATCCTGCGCGTCGATCATCCCGACATCAT
GAATTTCATCATGTGCAAGGCCGATAAGCACCAGTTGAATAATTTCAATATCTCCGTAGGGCTGACAGAAGTCTTCATGG
CCGCCGTAGAAGCGGATCAGGATTATGATCTCGTCAACCCGCGGGACGGTCAGGTCATCGGAACCCTGAATGCCCGAAAG
GTCTTCGACCGGATTGTTGCCCAGGCATGGGAAAACGGCGAGCCCGGAATCGTCTTTCTGGACCGCCTGAACCGCGACAA
CCCGACGCCCCATATCGGAGTGATCGAATCAACGAATCCTTGCGGAGAGCAGCCACTCCTGCCCTATGAATCCTGCAACC
TGGGATCGATCAATCTTGGAAAGATGGTGATAAACGGTGAAGTCAACTGGAAAAGACTCCGCGACGTCGTCAATCTTGCC
GTTCATTTCCTGGATAATGTCGTAGAAATCAATCAGTACCCCCTGCCCATCATTGCGGAGATGACATTCGGCAACCGTAA
AATCGGTCTGGGTGTCATGGGCTGGGCCGATATGCTCATTCAGCTCGGCATTCCTTACAATTCCGACCGGGCCCTCGAAC
TGGCCGAAGAAGTGATGAAATTCATCAACACGGAAGGTCATGATGCGTCGCACGCTTTGGCGAAGAAGAGGGGTCCGTTT
CCGAATTTCAAGGAGTCCCTGTACGACAAACAGGGAAAAGCACCAATTCGCAATGCGACCGTCACAACCATCGCGCCAAC
GGGAACCATCTCCATCATCGCCAACGCCTCATCCGGCGTAGAACCGCTTTTTGCCGTCTCCTACATACGTCAGGTGATGG
ACAATGATATCCTGCTGGAAATAAATCCCTTTTTTGAAGCCATGGCAAAAGAAAGAGGGTTCTACTCGAAGGAACTGATG
CGGAAGATTGCCGAACGCGGCACGATTCGTGATCTCGACGAGGTTCCGCAGGACATCCAGGCTGTTTTCGTAACGGCTCA
TGACATATCTCCGGAAGTGCACATCGGCATGCAGGCTGCCTTCCAGAAGTATACGGACAACGCCGTCAGCAAAACCGTCA
ACTTTGCTCACACGGCAACCATCGATGACGTTGCCAAGGTTTTTCGACTGGCCTATCAGTTGGATTGCAAGGGAGTCACG
ATCTACCGTGACGGTTCCCGGGACAACCAGGTCCTTTCGACGGGAAAAGAGCGTGAACAGCCTGTTCAGAAAAGCATGCC
CGAGGGAAGTAAGCTTGTCAAACGTGAGCGTCCGAAGGCATTGCAGGGTTGGACCTATCAAATGAAGACCGGCTGCGGAC
CGCTTTATGTAACGGTCAATCAGGACAGCTCCGGTCTATTCGAGCTGTTTACGACAATGGGGAAAGCCGGTGGTTGCGCG
GCATCCCAGAGCGAAGCCATCGGACGCATGGTCTCCCTGGCCTGGCGCAGCGGCATTTCAGGCAGGCAGGTAATCAAGCA
GTTGCAGGGCATTTCCTGTCACTCCCCTTCCGGATTTGGCGACAACAAGATTTTATCCTGTGCCGACGCCGTGGCAAAAG
CCATTCAGTCTCATATGGAGGCAAACGGCTATGACGCAGTCAGCGAAAGCGTTGCCGTGATCAAGGGCGCCTGTCCGGAG
TGCGGCGGGATTGTGGAGCACGAAGGCGGCTGCGCCGTCTGCCGTATATGCGGTTACAGTGAATGCAAATGA

Upstream 100 bases:

>100_bases
TGACATCTTCCATATATTGTTGTCAATAAAGGCCCCTCACACAAGATGTTGTACTTTTAGAACAATAATGATTCTGCAAT
TCACAAGGAGCGATTCCGAA

Downstream 100 bases:

>100_bases
TGCTTGTGTGCCGTATATTGCTTCCTCAATACGGGCTTGTTTGGCCATCTGTAAGCTTTTTTCGGAACATGGAAATGATA
TGATGGATCGTTTCGAGACT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 743; Mature: 743

Protein sequence:

>743_residues
MKKRTSSIDISSLTDNAIKVLGRRYLKRDRDGNALETPSQMFKRVADTIAAADRIFNDQADTAGLSDQFYRMMTALEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKFTALIHKSGGGTGFSFSRLRPANDVVLTTTGISSGPISFMRVFDV
ATETIKQGGTRRGANMGILRVDHPDIMNFIMCKADKHQLNNFNISVGLTEVFMAAVEADQDYDLVNPRDGQVIGTLNARK
VFDRIVAQAWENGEPGIVFLDRLNRDNPTPHIGVIESTNPCGEQPLLPYESCNLGSINLGKMVINGEVNWKRLRDVVNLA
VHFLDNVVEINQYPLPIIAEMTFGNRKIGLGVMGWADMLIQLGIPYNSDRALELAEEVMKFINTEGHDASHALAKKRGPF
PNFKESLYDKQGKAPIRNATVTTIAPTGTISIIANASSGVEPLFAVSYIRQVMDNDILLEINPFFEAMAKERGFYSKELM
RKIAERGTIRDLDEVPQDIQAVFVTAHDISPEVHIGMQAAFQKYTDNAVSKTVNFAHTATIDDVAKVFRLAYQLDCKGVT
IYRDGSRDNQVLSTGKEREQPVQKSMPEGSKLVKRERPKALQGWTYQMKTGCGPLYVTVNQDSSGLFELFTTMGKAGGCA
ASQSEAIGRMVSLAWRSGISGRQVIKQLQGISCHSPSGFGDNKILSCADAVAKAIQSHMEANGYDAVSESVAVIKGACPE
CGGIVEHEGGCAVCRICGYSECK

Sequences:

>Translated_743_residues
MKKRTSSIDISSLTDNAIKVLGRRYLKRDRDGNALETPSQMFKRVADTIAAADRIFNDQADTAGLSDQFYRMMTALEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKFTALIHKSGGGTGFSFSRLRPANDVVLTTTGISSGPISFMRVFDV
ATETIKQGGTRRGANMGILRVDHPDIMNFIMCKADKHQLNNFNISVGLTEVFMAAVEADQDYDLVNPRDGQVIGTLNARK
VFDRIVAQAWENGEPGIVFLDRLNRDNPTPHIGVIESTNPCGEQPLLPYESCNLGSINLGKMVINGEVNWKRLRDVVNLA
VHFLDNVVEINQYPLPIIAEMTFGNRKIGLGVMGWADMLIQLGIPYNSDRALELAEEVMKFINTEGHDASHALAKKRGPF
PNFKESLYDKQGKAPIRNATVTTIAPTGTISIIANASSGVEPLFAVSYIRQVMDNDILLEINPFFEAMAKERGFYSKELM
RKIAERGTIRDLDEVPQDIQAVFVTAHDISPEVHIGMQAAFQKYTDNAVSKTVNFAHTATIDDVAKVFRLAYQLDCKGVT
IYRDGSRDNQVLSTGKEREQPVQKSMPEGSKLVKRERPKALQGWTYQMKTGCGPLYVTVNQDSSGLFELFTTMGKAGGCA
ASQSEAIGRMVSLAWRSGISGRQVIKQLQGISCHSPSGFGDNKILSCADAVAKAIQSHMEANGYDAVSESVAVIKGACPE
CGGIVEHEGGCAVCRICGYSECK
>Mature_743_residues
MKKRTSSIDISSLTDNAIKVLGRRYLKRDRDGNALETPSQMFKRVADTIAAADRIFNDQADTAGLSDQFYRMMTALEFLP
NSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKFTALIHKSGGGTGFSFSRLRPANDVVLTTTGISSGPISFMRVFDV
ATETIKQGGTRRGANMGILRVDHPDIMNFIMCKADKHQLNNFNISVGLTEVFMAAVEADQDYDLVNPRDGQVIGTLNARK
VFDRIVAQAWENGEPGIVFLDRLNRDNPTPHIGVIESTNPCGEQPLLPYESCNLGSINLGKMVINGEVNWKRLRDVVNLA
VHFLDNVVEINQYPLPIIAEMTFGNRKIGLGVMGWADMLIQLGIPYNSDRALELAEEVMKFINTEGHDASHALAKKRGPF
PNFKESLYDKQGKAPIRNATVTTIAPTGTISIIANASSGVEPLFAVSYIRQVMDNDILLEINPFFEAMAKERGFYSKELM
RKIAERGTIRDLDEVPQDIQAVFVTAHDISPEVHIGMQAAFQKYTDNAVSKTVNFAHTATIDDVAKVFRLAYQLDCKGVT
IYRDGSRDNQVLSTGKEREQPVQKSMPEGSKLVKRERPKALQGWTYQMKTGCGPLYVTVNQDSSGLFELFTTMGKAGGCA
ASQSEAIGRMVSLAWRSGISGRQVIKQLQGISCHSPSGFGDNKILSCADAVAKAIQSHMEANGYDAVSESVAVIKGACPE
CGGIVEHEGGCAVCRICGYSECK

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=579, Percent_Identity=27.979274611399, Blast_Score=215, Evalue=1e-55,
Organism=Escherichia coli, GI1789030, Length=632, Percent_Identity=25.7911392405063, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI2367133, Length=530, Percent_Identity=22.8301886792453, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17555242, Length=585, Percent_Identity=28.034188034188, Blast_Score=218, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322123, Length=578, Percent_Identity=27.8546712802768, Blast_Score=197, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320914, Length=577, Percent_Identity=27.5563258232236, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17352481, Length=579, Percent_Identity=26.7702936096718, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 81320; Mature: 81320

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRTSSIDISSLTDNAIKVLGRRYLKRDRDGNALETPSQMFKRVADTIAAADRIFNDQA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DTAGLSDQFYRMMTALEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKFTALI
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDVVLTTTGISSGPISFMRVFDVATETIKQGGTRRGANMGILR
EECCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDHPDIMNFIMCKADKHQLNNFNISVGLTEVFMAAVEADQDYDLVNPRDGQVIGTLNARK
ECCHHHHHHHHHCCCHHHCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHH
VFDRIVAQAWENGEPGIVFLDRLNRDNPTPHIGVIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEC
KMVINGEVNWKRLRDVVNLAVHFLDNVVEINQYPLPIIAEMTFGNRKIGLGVMGWADMLI
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECEEHHHHHHHHH
QLGIPYNSDRALELAEEVMKFINTEGHDASHALAKKRGPFPNFKESLYDKQGKAPIRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSYIRQVMDNDILLEINPFFEAMAKERGFYSKELM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCHHHHHH
RKIAERGTIRDLDEVPQDIQAVFVTAHDISPEVHIGMQAAFQKYTDNAVSKTVNFAHTAT
HHHHHCCCCCCHHHCCHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
IDDVAKVFRLAYQLDCKGVTIYRDGSRDNQVLSTGKEREQPVQKSMPEGSKLVKRERPKA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHHCCHHHCCCCCHHHHHHCCCCH
LQGWTYQMKTGCGPLYVTVNQDSSGLFELFTTMGKAGGCAASQSEAIGRMVSLAWRSGIS
HCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GRQVIKQLQGISCHSPSGFGDNKILSCADAVAKAIQSHMEANGYDAVSESVAVIKGACPE
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
CGGIVEHEGGCAVCRICGYSECK
CCCCEECCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKKRTSSIDISSLTDNAIKVLGRRYLKRDRDGNALETPSQMFKRVADTIAAADRIFNDQA
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
DTAGLSDQFYRMMTALEFLPNSPTLMNAGRELGQLSACFVLPVGDSMEDIFDAVKFTALI
CCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHHHE
HKSGGGTGFSFSRLRPANDVVLTTTGISSGPISFMRVFDVATETIKQGGTRRGANMGILR
EECCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
VDHPDIMNFIMCKADKHQLNNFNISVGLTEVFMAAVEADQDYDLVNPRDGQVIGTLNARK
ECCHHHHHHHHHCCCHHHCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHH
VFDRIVAQAWENGEPGIVFLDRLNRDNPTPHIGVIESTNPCGEQPLLPYESCNLGSINLG
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEC
KMVINGEVNWKRLRDVVNLAVHFLDNVVEINQYPLPIIAEMTFGNRKIGLGVMGWADMLI
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECEEHHHHHHHHH
QLGIPYNSDRALELAEEVMKFINTEGHDASHALAKKRGPFPNFKESLYDKQGKAPIRNAT
HHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCE
VTTIAPTGTISIIANASSGVEPLFAVSYIRQVMDNDILLEINPFFEAMAKERGFYSKELM
EEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCHHHHHH
RKIAERGTIRDLDEVPQDIQAVFVTAHDISPEVHIGMQAAFQKYTDNAVSKTVNFAHTAT
HHHHHCCCCCCHHHCCHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
IDDVAKVFRLAYQLDCKGVTIYRDGSRDNQVLSTGKEREQPVQKSMPEGSKLVKRERPKA
HHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCHHHHCCHHHCCCCCHHHHHHCCCCH
LQGWTYQMKTGCGPLYVTVNQDSSGLFELFTTMGKAGGCAASQSEAIGRMVSLAWRSGIS
HCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GRQVIKQLQGISCHSPSGFGDNKILSCADAVAKAIQSHMEANGYDAVSESVAVIKGACPE
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
CGGIVEHEGGCAVCRICGYSECK
CCCCEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]